Enrolling adolescents in research on HIV and other sensitive issues: lessons from South Africa

Jerome Amir Singh, Salim S Abdool Karim, Quarraisha Abdool Karim, Koleka Mlisana, Carolyn Williamson, Clive Gray, Michelle Govender, Andrew Gray, Jerome Amir Singh, Salim S Abdool Karim, Quarraisha Abdool Karim, Koleka Mlisana, Carolyn Williamson, Clive Gray, Michelle Govender, Andrew Gray

Abstract

Jerome Singh and colleagues present the ethical and legal challenges surrounding the enrollment of adolescents in HIV observational studies and other types of sensitive research.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Sex education at an adolescent drama group…
Sex education at an adolescent drama group in Soweto, South Africa
(Photo: Arjen van de Merwe/Population Concern)

References

    1. Abdool Karim Q, Abdool Karim SS. South Africa: Host to a new and emerging HIV epidemic. Sex Transm Infect. 1999;75:139–140.
    1. Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. N Engl J Med. 2000;342:921–929.
    1. Wilson CM, Houser J, Partlow C. The REACH Project: Study, design, methods, and population profile. J Adolesc Health. 2001;29:8–18.
    1. Joint United Nations Programme on HIV/ AIDS [UNAIDS] Reference point 18. Geneva: UNAIDS; 2000. Ethical considerations in HIV preventative vaccine research. Available: . Accessed 6 December 2005.
    1. Strode A, Slack C, Grant C, Mushariwa C. Ethical and legal challenges in enrolling adolescents in medical research in South Africa: Implications for HIV vaccine trials. S Afr J Sci. 2005;101:224–228.
    1. Slack C, Strode A, Grant C, Milford C. Implications of the ethical-legal framework for adolescent HIV vaccine trials—Report of a consultative forum. S Afr Med J. 2005;95:682–684.
    1. Strode A, Slack C, Mushariwa M. HIV vaccine research—South Africa's ethical-legal framework and its ability to promote the welfare of trial Participants. S Afr Med J. 2005;95:598–601.
    1. Shisana O, Simbayl L. Nelson Mandela HSRC study on HIV/AIDS: Full report. Cape Town: HSRC Press; 2002. 121 pp. p Available: . Accessed 17 March 2006.
    1. Shisana O, Rehle T, Simbayi LC, Parker W, Zuma K, et al. South African national HIV incidence, HIV prevalence, behaviour and communications survey. Cape Town: HSRC Press; 2005. 156 pp. p Available: . Accessed 17 March 2006.
    1. Kharsany A, Carrara H, Frohlich J, Abdool Karim SS, Abdool Karim Q. HIV seroprevalence in rural KwaZulu–Natal in 2004—Implications for research and programmatic priority setting [abstract] 2nd. South Africa AIDS Conference; 2005 7–10 June; Durban, South Africa. 2005. In press.
    1. Council for the International Organisation of Medical Sciences [CIOMS] International ethical guidelines for biomedical research involving human subjects. Geneva: CIOMS; 2002. Available: . Accessed 17 March 2006.
    1. [Anonymous] Act 108 of 1996: Constitution of the Republic of South Africa. 1996 Available: . Accessed 17 March 2006.
    1. South African. Medical Research Council. Guidelines on ethics for medical research: General principles. Cape Town: South African Medical Research Council; 2002. Available: . Accessed 22 March 2006.
    1. Slack C, Kruger M. The South African Medical Research Council's Guidelines on Ethics for Medical Research—Implications for HIV preventive vaccine trials with children. S Afr Med J. 2005;95:269–271.
    1. South African. Medical Research Council. Guidelines on ethics for medical research: HIV preventive vaccine trials. Cape Town: South African Medical Research Council; 2003. Available: . Accessed 16 March 2006.
    1. Republic of. South Africa. Guidelines for good practice in the conduct of clinical trials in human participants in South Africa. Pretoria: National Health Research Ethics Committee; 2000. Available: . Accessed 16 March 2006.
    1. Strode A, Grant C, Slack C, Mushariwa M. How well does South Africa's National Health Act regulate research involving children? S Afr Med J. 2005;95:265–268.
    1. South African. National Health Research Ethics Committee. Ethics in health research: Principles, structures and processes. Pretoria: National Health Research Ethics Committee; 2004. Available: . Accessed 16 March 2006.
    1. Republic of. South Africa. Children's Bill, B70-2003 (Reintroduced 2005) 2003 Available: . Accessed 16 March 2006.
    1. United Nations Development Programme United Nations Populations Fund World Health Organization World Bank Special Programme of Research Development and Research Training in Human Reproduction. Guidelines for research on reproductive health involving adolescents. Geneva: World Health Organization; 1994. Available: . Accessed 16 March 2006.
    1. Frohlich JA, Abdool Karim Q, Biyela D, Abdool Karim SS. Developing partnerships in preparing communities for HIV prevention and vaccine efficacy trials: Experiences from rural South Africa. In: Girard M, Dodet B, editors. Retroviruses of human AIDS and related animal diseases. New York: Elsevier Science Publishing Company; 2003. pp. 191–197.
    1. Macpherson CC. To strengthen consensus, consult the stakeholders. Bioethics. 2004;18:283–292.
    1. Quinn SC. Ethics in public health research: Protecting human subjects: the role of community advisory boards. Am J Public Health. 2004;94:918–922.

Source: PubMed

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