Successful Re-treatment of Hepatitis C Virus in Patients Coinfected With HIV Who Relapsed After 12 Weeks of Ledipasvir/Sofosbuvir
Curtis Cooper, Susanna Naggie, Michael Saag, Jenny C Yang, Luisa M Stamm, Hadas Dvory-Sobol, LingLing Han, Phillip S Pang, John G McHutchison, Douglas Dieterich, Mark Sulkowski, Curtis Cooper, Susanna Naggie, Michael Saag, Jenny C Yang, Luisa M Stamm, Hadas Dvory-Sobol, LingLing Han, Phillip S Pang, John G McHutchison, Douglas Dieterich, Mark Sulkowski
Abstract
We assessed the efficacy and safety of ledipasvir/sofosbuvir plus ribavirin for 24 weeks in 9 human immunodeficiency virus/hepatitis C virus-coinfected patients who relapsed after receiving 12 weeks of treatment with ledipasvir/sofosbuvir. Eight of 9 (89%) achieved sustained virologic response 12 weeks after the end of treatment. One patient relapsed at posttreatment week 4. These results suggest an effective salvage therapy for patients for whom direct-acting antiviral treatment has failed.
Clinical trials registration: NCT02073656.
Keywords: HCV NS5B polymerase inhibitor; HCV/HIV coinfection; NS5A resistance; direct-acting antiviral agents; re-treatment.
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
Source: PubMed