Preliminary results from a prospective study using limited margin radiotherapy in pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft-tissue sarcoma
Matthew J Krasin, Andrew M Davidoff, Xiaoping Xiong, Shengjie Wu, Chia-Ho Hua, Fariba Navid, Carlos Rodriguez-Galindo, Bhaskar N Rao, Kelly A Hoth, Michael D Neel, Thomas E Merchant, Larry E Kun, Sheri L Spunt, Matthew J Krasin, Andrew M Davidoff, Xiaoping Xiong, Shengjie Wu, Chia-Ho Hua, Fariba Navid, Carlos Rodriguez-Galindo, Bhaskar N Rao, Kelly A Hoth, Michael D Neel, Thomas E Merchant, Larry E Kun, Sheri L Spunt
Abstract
Purpose: To demonstrate the safety and efficacy of limited margin radiotherapy in the local control of pediatric and young adult patients with high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS).
Methods and materials: Pediatric patients with high-grade NRSTS requiring radiation were treated on an institutional review board approved prospective institutional study of conformal/intensity-modulated/interstitial brachytherapy using a 2-cm anatomically constrained margin.
Results: A total of 32 patients (median age, 15.3 years; range, 2-22 years) received adjuvant (27 patients) or definitive (5 patients) irradiation. With a median follow-up of 32 months, the 3-year cumulative incidence of local failure was 3.7% for patients undergoing irradiation after surgical resection. Four patients experienced local failure; the mean dose to the volume of recurrence was >or=97% of the prescribed dose.
Conclusions: Delivery of limited margin radiotherapy using external beam or brachytherapy provides a high rate of local tumor control without marginal failure. Further follow-up is required to determine whether normal tissue effects are minimized using this approach.
Conflict of interest statement
Conflicts of Interest Notification
No conflicts of interest exist.
Copyright (c) 2010 Elsevier Inc. All rights reserved.
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Source: PubMed