Trends and factors associated with initial and recurrent methicillin-resistant Staphylococcus aureus (MRSA) skin and soft-tissue infections among HIV-infected persons: an 18-year study
Kartavya J Vyas, Aladdin H Shadyab, Chii-Dean Lin, Nancy F Crum-Cianflone, Kartavya J Vyas, Aladdin H Shadyab, Chii-Dean Lin, Nancy F Crum-Cianflone
Abstract
Background: Factors associated with initial methicillin-resistant Staphylococcus aureus (MRSA) skin and soft-tissue infections (SSTIs) and their recurrence have not been fully elucidated among HIV-infected persons.
Methods: We retrospectively evaluated a large cohort of HIV-infected patients from 1993 to 2010 for culture-proven MRSA SSTIs. Separate logistic regression models evaluated factors associated with initial and recurrent infections.
Results: Of the 794 patients, 63 (8%) developed an initial infection (19.8 infections/1000 person years [PY]); risk factors included CD4 count <500 cells/mm(3) and HIV RNA level ≥400 copies/mL (P < .01), US Centers for Disease Control and Prevention (CDC) stage C versus A/B (P < .01), and injection drug use (IDU, P < .01). In all, 27% developed recurrence (206 infections/1000 PY); risk factors included hospital admission (P = .02). Minocycline for treatment of the initial infection was associated with an 80% decreased odds for recurrence (P = .03).
Conclusion: HIV control and avoidance of IDU may be useful in reducing rates of MRSA SSTIs among HIV-infected persons.
Keywords: HIV; MRSA; epidemiology; recurrence; risk factors.
Source: PubMed