The impact of avoiding cardiopulmonary by-pass during coronary artery bypass surgery in elderly patients: the Danish On-pump Off-pump Randomisation Study (DOORS)
Kim Houlind, Bo Juul Kjeldsen, Susanne Nørgaard Madsen, Bodil Steen Rasmussen, Susanne Juel Holme, Thomas Andersen Schmidt, Poul Erik Haahr, Poul Erik Mortensen, DOORS study group, Kim Houlind, Bo Juul Kjeldsen, Susanne Madsen, Bodil Steen Rasmussen, Susanne Holme, Poul Erik Mortensen, Vibeke Hjortdal, Gert Lerbjerg, Soren Aggestrup, Susanne Holme, Per Hostrup Nielsen, Jorn Sollid, Jorgen Videbaek, Kim Houlind, Paul Sergeant, Elisabeth Stahle, Patrick Wouters, Peter Kildeberg Paulsen, Christian Hassager, Ib Chr Klausen, Grethe Andersen, Per Meden, Boris Modrau, Henrik Toft Sørensen, Søren Paaske Johnsen, Niels Trolle Andersen, Jakob Jakobsen, Jan Jesper Andreassen, Poul Erik Haahr, John Christensen, Jens Grønlund, Susanne Holme, Per Hostrup Nielsen, Mogens Harrits Jepsen, Bo Juul Kjeldsen, Susanne Madsen, Poul Erik Mortensen, Peter Pallesen, Jørn Sollid, Jan Ravkilde, Jens Aaroe, Peter Riis Hansen, Henrik Steen Hansen, Dorthe Dalsgaard, Henrik Munkholm, Kim Houlind, Bo Juul Kjeldsen, Susanne Nørgaard Madsen, Bodil Steen Rasmussen, Susanne Juel Holme, Thomas Andersen Schmidt, Poul Erik Haahr, Poul Erik Mortensen, DOORS study group, Kim Houlind, Bo Juul Kjeldsen, Susanne Madsen, Bodil Steen Rasmussen, Susanne Holme, Poul Erik Mortensen, Vibeke Hjortdal, Gert Lerbjerg, Soren Aggestrup, Susanne Holme, Per Hostrup Nielsen, Jorn Sollid, Jorgen Videbaek, Kim Houlind, Paul Sergeant, Elisabeth Stahle, Patrick Wouters, Peter Kildeberg Paulsen, Christian Hassager, Ib Chr Klausen, Grethe Andersen, Per Meden, Boris Modrau, Henrik Toft Sørensen, Søren Paaske Johnsen, Niels Trolle Andersen, Jakob Jakobsen, Jan Jesper Andreassen, Poul Erik Haahr, John Christensen, Jens Grønlund, Susanne Holme, Per Hostrup Nielsen, Mogens Harrits Jepsen, Bo Juul Kjeldsen, Susanne Madsen, Poul Erik Mortensen, Peter Pallesen, Jørn Sollid, Jan Ravkilde, Jens Aaroe, Peter Riis Hansen, Henrik Steen Hansen, Dorthe Dalsgaard, Henrik Munkholm
Abstract
Background: Coronary Artery Bypass Graft operation for ischemic heart disease provides improved quality of life and, in some patients, prolonged survival. Concern has, however, been raised about complications that may be related to the use of cardiopulmonary by-pass (CPB) and aortic cross-clamping. It has been hypothesized that when coronary artery by-pass grafting is performed without the use of CPB, the rate of serious complications is reduced.
Methods/design: The trial is designed as an open, randomized, controlled, clinical trial with blinded assessment of end-points. Patients at or above 70 years of age, referred for surgical myocardial revascularisation, are included and randomised to receive coronary artery by-pass grafting either with or without the use of CPB and aortic cross-clamping. Follow-up is performed by clinical, biochemical, electrocardiographic, and angiographic data that are evaluated by independent committees that are blinded with respect to the result of the randomisation. End points include mortality, stroke, myocardial infarction, graft patency, quality of life, and cost-effectiveness. The trial is performed in four different Danish, cardiac surgery centres.
Trial registration: ClinicalTrials.gov NCT00123981.
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Source: PubMed