How do general practitioners and pharmacists experience antibiotic use in out-of-hours primary care? An exploratory qualitative interview study to inform a participatory action research project

Annelies Colliers, Samuel Coenen, Roy Remmen, Hilde Philips, Sibyl Anthierens, Annelies Colliers, Samuel Coenen, Roy Remmen, Hilde Philips, Sibyl Anthierens

Abstract

Rationale: Antibiotics (ABs) are one of the most prescribed medications in out-of-hours (OOH) care in Belgium. Developing a better understanding of why ABs are prescribed in this setting is essential to improve prescribing habits.

Objectives: To assess AB prescribing and dispensing challenges for general practitioners (GPs) and pharmacists in OOH primary care, and to identify context-specific elements that can help the implementation of behaviour change interventions to improve AB prescribing in this setting.

Design: This is an exploratory qualitative study using semistructured interviews. This study is part of a participatory action research project.

Setting and participants: Participants include 17 GPs and 1 manager, who work in a Belgian OOH general practitioners cooperative (GPC), and 5 pharmacists of the area covered by the GPC. The GPC serves a population of more than 187 000 people.

Results: GPs feel the threshold to prescribe AB in OOH care is lower in comparion to office hours. GPs and pharmacists talk about the difference in their professional identity in OOH (they define their task differently, they feel more isolated, insecure, have the need to please and so on), type of patients (unknown patients, vulnerable patients, other ethnicities, demanding patients and so on), workload (they feel time-pressured) and lack of diagnostic tools or follow-up. They are aware of the problem of AB overprescribing, but they do not feel ownership of the problem.

Conclusion: The implementation of behaviour change interventions to improve AB prescribing in OOH primary care has to take these context specifics into account and could involve interprofessional collaboration between GPs and pharmacists.

Trial registration number: NCT03082521; Pre-results.

Keywords: antibiotics; out-of-hours care; participatory action research; practitioner cooperative; primary care; qualitative research.

Conflict of interest statement

Competing interests: None declared.

© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

References

    1. European Centre for Disease Prevention and Control, 2017. Summary of the latest data on antibiotic consumption in the European Union (accessed 19 Jan 2018).
    1. Huibers L, Philips H, Giesen P, et al. . EurOOHnet-the European research network for out-of-hours primary health care. Eur J Gen Pract 2014;20:229–32. 10.3109/13814788.2013.846320
    1. Philips H, Mahr D, Remmen R, et al. . Predicting the place of out-of-hours care--a market simulation based on discrete choice analysis. Health Policy 2012;106:284–90. 10.1016/j.healthpol.2012.04.010
    1. Philips H. Out-of-hours care in Belgium Dissertation for the degree of doctor in Medical Science at the University of Antwerp, 2010:ISBN: 9789057283109.
    1. Adriaenssens N, Bartholomeeusen S, Ryckebosch P, et al. . Quality of antibiotic prescription during office hours and out-of-hours in Flemish primary care, using European quality indicators. Eur J Gen Pract 2014;20:114–20. 10.3109/13814788.2013.828200
    1. Bartholomeeusen S, Philips H, Van Royen P, et al. . iCAREdata: improving care and research electronic data trust Antwerp: Zenodo, 2017.
    1. Colliers A, Bartholomeeusen S, Remmen R, et al. . Improving Care And Research Electronic Data Trust Antwerp (iCAREdata): a research database of linked data on out-of-hours primary care. BMC Res Notes 2016;9:259 10.1186/s13104-016-2055-x
    1. Williams SJ, Halls AV, Tonkin-Crine S, et al. . General practitioner and nurse prescriber experiences of prescribing antibiotics for respiratory tract infections in UK primary care out-of-hours services (the UNITE study). J Antimicrob Chemother 2018;73:795–803. 10.1093/jac/dkx429
    1. Lindberg BH, Gjelstad S, Foshaug M, et al. . Antibiotic prescribing for acute respiratory tract infections in Norwegian primary care out-of-hours service. Scand J Prim Health Care 2017;35:178–85. 10.1080/02813432.2017.1333301
    1. Hayward GN, Fisher RF, Spence GT, et al. . Increase in antibiotic prescriptions in out-of-hours primary care in contrast to in-hours primary care prescriptions: service evaluation in a population of 600 000 patients. J Antimicrob Chemother 2016;71:2612–9. 10.1093/jac/dkw189
    1. Dyrkorn R, Gjelstad S, Espnes KA, et al. . Peer academic detailing on use of antibiotics in acute respiratory tract infections. A controlled study in an urban Norwegian out-of-hours service. Scand J Prim Health Care 2016;34:180–5. 10.3109/02813432.2016.1163035
    1. de Bont EG, Dinant GJ, Elshout G, et al. . An illness-focused interactive booklet to optimise management and medication for childhood fever and infections in out-of-hours primary care: study protocol for a cluster randomised trial. Trials 2016;17:547 10.1186/s13063-016-1667-8
    1. Willems L, Denckens P, Philips H, et al. . Can we improve adherence to guidelines for the treatment of lower urinary tract infection? A simple, multifaceted intervention in out-of-hours services. J Antimicrob Chemother 2012;67:2997–3000. 10.1093/jac/dks336
    1. Colliers A, Coenen S, Philips H, et al. . Optimising the quality of antibiotic prescribing in out-of-hours primary care in Belgium: a study protocol for an action research project. BMJ Open 2017;7:e017522 10.1136/bmjopen-2017-017522
    1. Meyer J. Qualitative research in health care. Using qualitative methods in health related action research. BMJ 2000;320:178–81. 10.1136/bmj.320.7228.178
    1. Meyer J. Evaluating action research. Age Ageing 2000;29(Suppl 2):8–10. 10.1093/oxfordjournals.ageing.a008104
    1. Sikkens JJ, van Agtmael MA, Peters EJG, et al. . Behavioral approach to appropriate antimicrobial prescribing in hospitals: the Dutch Unique Method for Antimicrobial Stewardship (DUMAS) participatory intervention study. JAMA Intern Med 2017;177:1130–8. 10.1001/jamainternmed.2017.0946
    1. van Buul LW, Sikkens JJ, van Agtmael MA, et al. . Participatory action research in antimicrobial stewardship: a novel approach to improving antimicrobial prescribing in hospitals and long-term care facilities. J Antimicrob Chemother 2014;69:1734–41. 10.1093/jac/dku068
    1. Klepser ME, Dobson EL, Pogue JM, et al. . A call to action for outpatient antibiotic stewardship. J Am Pharm Assoc 2017;57:457–63. 10.1016/j.japh.2017.03.013
    1. Coxeter P, Del Mar CB, McGregor L, et al. . Interventions to facilitate shared decision making to address antibiotic use for acute respiratory infections in primary care. Cochrane Database Syst Rev 2015:CD010907 10.1002/14651858.CD010907.pub2
    1. Cross EL, Tolfree R, Kipping R. Systematic review of public-targeted communication interventions to improve antibiotic use. J Antimicrob Chemother 2017;72:975–87. 10.1093/jac/dkw520
    1. Tonkin-Crine SK, Tan PS, van Hecke O, et al. . Clinician-targeted interventions to influence antibiotic prescribing behaviour for acute respiratory infections in primary care: an overview of systematic reviews. Cochrane Database Syst Rev 2017;9:Cd012252 10.1002/14651858.CD012252.pub2
    1. van der Velden AW, Pijpers EJ, Kuyvenhoven MM, et al. . Effectiveness of physician-targeted interventions to improve antibiotic use for respiratory tract infections. Br J Gen Pract 2012;62:e801–7. 10.3399/bjgp12X659268
    1. Papoutsi C, Mattick K, Pearson M, et al. . Social and professional influences on antimicrobial prescribing for doctors-in-training: a realist review. J Antimicrob Chemother 2017;72:2418–30. 10.1093/jac/dkx194
    1. Strandberg EL, Brorsson A, Hagstam C, et al. . "I’m Dr Jekyll and Mr Hyde": are GPs' antibiotic prescribing patterns contextually dependent? A qualitative focus group study. Scand J Prim Health Care 2013;31:158–65. 10.3109/02813432.2013.824156
    1. McNiff J, Whitehead J. All you need to know about action research. California: SAGE, 2011.
    1. Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol 2006;3:77–101. 10.1191/1478088706qp063oa
    1. Ritchie J, Spencer L. Qualitative data analysis for applied policy research Analysing qualitative data. London: Routledge, 2002;573:305–29.
    1. Braun V, Clarke V. Successful qualitative research: a practical guide for beginners. London: Sage, 2013.
    1. Quirkos. Qualitative data analysis software. (accessed 19 Jan 2018).
    1. Tonkin-Crine S, Yardley L, Coenen S, et al. . Strategies to promote prudent antibiotic use: exploring the views of professionals who develop and implement guidelines and interventions. Fam Pract 2013;30:88–95. 10.1093/fampra/cms043
    1. Brookes-Howell L, Hood K, Cooper L, et al. . Understanding variation in primary medical care: a nine-country qualitative study of clinicians' accounts of the non-clinical factors that shape antibiotic prescribing decisions for lower respiratory tract infection. BMJ Open 2012;2:e000796 10.1136/bmjopen-2011-000796
    1. Roque F, Teixeira-Rodrigues A, Breitenfeld L, et al. . Decreasing antibiotic use through a joint intervention targeting physicians and pharmacists. Future Microbiol 2016;11:877–86. 10.2217/fmb-2016-0010
    1. Roque F, Soares S, Breitenfeld L, et al. . Attitudes of community pharmacists to antibiotic dispensing and microbial resistance: a qualitative study in Portugal. Int J Clin Pharm 2013;35:417–24. 10.1007/s11096-013-9753-4
    1. Dey RM, de Vries MJ, Bosnic-Anticevich S. Collaboration in chronic care: unpacking the relationship of pharmacists and general medical practitioners in primary care. Int J Pharm Pract 2011;19:21–9. 10.1111/j.2042-7174.2010.00070.x
    1. Vervloet M, Meulepas MA, Cals JW, et al. . Reducing antibiotic prescriptions for respiratory tract infections in family practice: results of a cluster randomized controlled trial evaluating a multifaceted peer-group-based intervention. NPJ Prim Care Respir Med 2016;26:15083 10.1038/npjpcrm.2015.83
    1. Broom A, Broom J, Kirby E, et al. . The path of least resistance? Jurisdictions, responsibility and professional asymmetries in pharmacists' accounts of antibiotic decisions in hospitals. Soc Sci Med 2015;146:95–103. 10.1016/j.socscimed.2015.10.037

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