The impact of short stature on health-related quality of life in children with chronic kidney disease
Amira Al-Uzri, Matthew Matheson, Debbie S Gipson, Susan R Mendley, Stephen R Hooper, Ora Yadin, David J Rozansky, Marva Moxey-Mims, Susan L Furth, Bradley A Warady, Arlene C Gerson, Chronic Kidney Disease in Children Study Group, Bradley Warady, Colin White, Ellen Wood, Sahar Fathallah, Nancy Rodig, William Harmon, Gary Lerner, Tom Blydt-Hansen, Randall Jenkins, Bradley Warady, Jens Goebel, Mark Mitsnefes, Larry Greenbaum, Colleen Hastings, Cynthia Pan, Martin Turman, Amira Al-Uzri, Randall Jenkins, Bruce Morgenstern, Katherine Dell, Joseph Flynn, S Paul Hmiel, Cynthia Wong, Steven Alexander, Anthony Portale, Isidro Salusky, Ora Yadin, Nadine Benador, Robert Mak, Craig Wong, Mouin Seikaly, Sharon Bartosh, Deborah Jones, Craig Langman, Susan Massengill, Frederick Kaskel, Tej Matoo, Kanwal Kher, Susan Furth, Yi Cai, Guillermo Hidalgo, Rulan Parekh, Lisa Robinson, Lauren Weintraub, Meredith Atkinson, Juan Kupferman, Dmitry Samsonov, Jeffrey Saland, Hiren Patel, Sharon Andreoli, Lynne Weiss, Anil Mongia, Poyyapakkam Srivaths, Richard Neiberger, Eunice John, Patrick Brophy, Susan Mendley, Debbie Gipson, Maria Ferris, Marc Lande, George Schwartz, Joshua Samuels, Victoria Norwood, Amira Al-Uzri, Matthew Matheson, Debbie S Gipson, Susan R Mendley, Stephen R Hooper, Ora Yadin, David J Rozansky, Marva Moxey-Mims, Susan L Furth, Bradley A Warady, Arlene C Gerson, Chronic Kidney Disease in Children Study Group, Bradley Warady, Colin White, Ellen Wood, Sahar Fathallah, Nancy Rodig, William Harmon, Gary Lerner, Tom Blydt-Hansen, Randall Jenkins, Bradley Warady, Jens Goebel, Mark Mitsnefes, Larry Greenbaum, Colleen Hastings, Cynthia Pan, Martin Turman, Amira Al-Uzri, Randall Jenkins, Bruce Morgenstern, Katherine Dell, Joseph Flynn, S Paul Hmiel, Cynthia Wong, Steven Alexander, Anthony Portale, Isidro Salusky, Ora Yadin, Nadine Benador, Robert Mak, Craig Wong, Mouin Seikaly, Sharon Bartosh, Deborah Jones, Craig Langman, Susan Massengill, Frederick Kaskel, Tej Matoo, Kanwal Kher, Susan Furth, Yi Cai, Guillermo Hidalgo, Rulan Parekh, Lisa Robinson, Lauren Weintraub, Meredith Atkinson, Juan Kupferman, Dmitry Samsonov, Jeffrey Saland, Hiren Patel, Sharon Andreoli, Lynne Weiss, Anil Mongia, Poyyapakkam Srivaths, Richard Neiberger, Eunice John, Patrick Brophy, Susan Mendley, Debbie Gipson, Maria Ferris, Marc Lande, George Schwartz, Joshua Samuels, Victoria Norwood
Abstract
Objectives: To compare the health-related quality of life (HRQoL) of children with chronic kidney disease (CKD) and short stature (SS) with that of children with CKD and normal height (NH), to evaluate the impact of catch-up growth and growth hormone (GH) use on HRQoL, and to describe the concordance of perceptions of HRQoL between children with SS and NH and their parents.
Study design: Four hundred eighty-three children and/or parents enrolled in the multicenter Chronic Kidney Disease in Children study who had completed the Pediatric Quality of Life Inventory (Version 4.0) on at least 2 Chronic Kidney Disease in Children study visits composed this substudy population. Participants were dichotomized into NH or SS groups. The demographic characteristics that varied at baseline (sex, glomerular filtration rate, and parent education) were controlled for in the main analysis evaluating the impact of catch-up growth and use of GH on HRQoL.
Results: Multivariate modeling (controlling for confounding variables) revealed a significant association between both catch-up growth and GH use on parent-proxy reports of child physical functioning (P < .05) and social functioning (P < .05). Older children with CKD (15-17 years old) had significantly higher ratings than their parents on the Pediatric Quality of Life Inventory Physical, Emotional, Social, and School Functioning scales compared with younger children (8-14 years old).
Conclusion: The finding that height gains and GH use are associated with increases in physical and social functioning by parent report provides additional support for interventions to improve height in children with CKD. The importance of evaluating both the parent and child perceptions of HRQoL is supported by our results.
Trial registration: ClinicalTrials.gov NCT00327860.
Keywords: CKD; CKiD; Chronic Kidney Disease in Children; Chronic kidney disease; Estimated glomerular filtration rate; GH; Growth hormone; HRQoL; Health-related quality of life; Iohexol-based glomerular filtration rate; ME; Maternal education; NH; Normal height; Pediatric Quality of Life Inventory; PedsQL; Reflects the use of iGFR if it is available, eGFR if it is not; SS; Short stature; eGFR; iGFR; ieGFR.
Conflict of interest statement
The authors declare no conflicts of interest.
Copyright © 2013 Mosby, Inc. All rights reserved.
Source: PubMed