Mean Arterial Pressure and Chronic Kidney Disease Progression in the CKiD Cohort
Janis M Dionne, Shuai Jiang, Derek K Ng, Joseph T Flynn, Mark M Mitsnefes, Susan L Furth, Bradley A Warady, Joshua A Samuels, CKiD study group, Janis M Dionne, Shuai Jiang, Derek K Ng, Joseph T Flynn, Mark M Mitsnefes, Susan L Furth, Bradley A Warady, Joshua A Samuels, CKiD study group
Abstract
[Figure: see text].
Trial registration: ClinicalTrials.gov NCT00327860.
Keywords: arterial pressure; blood pressure; disease progression; pediatrics; proteinuria.
Conflict of interest statement
Disclosures
The authors have no conflicts to disclose.
Figures
Survival functions of time to renal replacement therapy (RRT) or 50% decline in GFR by ambulatory MAP percentile category, stratified by non-glomerular and glomerular diagnoses.
Relative hazards of renal replacement therapy or 50% decline in GFR by MAP percentile categories, stratified by non-glomerular (◼) and glomerular (▲) diagnoses. Results are presented unadjusted, minimally adjusted for age, gender and race, and adjusted for age, gender, race and proteinuria level (uPrCr). For children with non-glomerular diagnosis, time-varying risk was characterized by ≤ 4 years and > 4 years from baseline. No significant time-varying risk was observed among children with glomerular diagnoses.
Proportion of ACEi/ARB therapy use by MAP percentile category and visit, stratified by non-glomerular and glomerular diagnosis. Within each cell, the size of the shaded polygon is proportional to those using ACEi/ARB therapy. Darker shaded polygons indicate higher number of participants in each cell.
Source: PubMed