Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design

Yun Ju Jun, Jinhee Lee, Sehee Hwang, Jung Hyun Kwak, Hyeon Yeong Ahn, Youn Kyung Bak, Jihoon Koh, Jong Ho Lee, Yun Ju Jun, Jinhee Lee, Sehee Hwang, Jung Hyun Kwak, Hyeon Yeong Ahn, Youn Kyung Bak, Jihoon Koh, Jong Ho Lee

Abstract

Background: Previous studies have reported that xylose selectively inhibited the activity of sucrase. Xylose supplementation may have a beneficial effect on the postprandial glycemic response. However, no studies have investigated patients with IFG or the effectivity of a dose of D-xylose less than 10 % (w/w).

Methods: The present study determined the effect of xylose consumption on postprandial hyperglycemia in normal (n = 25) and hyperglycemic subjects (n = 50). Subjects in this double-blind crossover design study were randomly assigned to consume a sucrose drink (Control, sucrose 50 g + deionized water 100 g) or a sucrose drink additionally containing 5 g (Test 1, sucrose:xylose = 10:1), 3.33 g (Test 2, sucrose:xylose = 15:1), or 2.5 g (Test 3, sucrose:xylose = 20:1) of D-xylose separated by a one-week interval.

Results: Normal subjects in all test groups exhibited a significant decrease in serum glucose levels 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. Significantly lower serum levels of insulin were observed at 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. The test 1 group also exhibited a significantly lower insulin area under the curve than the control group. Hyperglycemic subjects (n = 50) in all test groups exhibited a significant decrease in serum glucose levels at 30 min compared to the control group. However, the test 1 group exhibited a significant increase in serum glucose levels at 120 min compared to the control group. Glucose-related markers did not significantly differ in each group.

Conclusion: Xylose supplementation may exert a beneficial effect on postprandial glycemic responses in subjects with normal glucose levels and prediabetes.

Trial registration: ClinicalTrials.gov identifier: NCT02654301 . Registered 12 January 2016.

Keywords: Glucose; Postprandial hyperglycemia; Prediabetes; Xylose.

Figures

Fig. 1
Fig. 1
Serum glucose levels in normal subjects. Values are expressed as the means ± SEM. p-value tested using one-way analysis of variance (ANOVA) and Bonferroni methods
Fig. 2
Fig. 2
Comparisons of changes in serum glucose levels in normal subjects. Values are expressed as the means ± SEM. p-value tested using one-way analysis of variance (ANOVA) and Bonferroni methods
Fig. 3
Fig. 3
Serum glucose levels in hyperglycemic subjects. Values are expressed as the means ± SEM. p-value tested using one-way analysis of variance (ANOVA) and Bonferroni methods
Fig. 4
Fig. 4
Comparisons of changes in serum glucose levels in hyperglycemic subjects. Values are expressed as the means ± SEM. p-value tested using one-way analysis of variance (ANOVA) and Bonferroni methods

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Source: PubMed

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