Phantom limb pain: A literature review

Amreet Kaur, Yuxi Guan, Amreet Kaur, Yuxi Guan

Abstract

Since the phantom limb sensation was first described by the French military surgeon Ambroise Pare in the 16th century, the number of studies surrounding phantom limb pain has increased every year. Especially in recent decades, scientists have achieved a better understanding of the mechanism and treatment of phantom limb pain. Although many hypotheses have been agreed and many treatments have been proven effective, scientists still do not have a very systematic understanding of the phantom limbs. The purpose of this review article is to summarize recent researches focusing on phantom limb in order to discuss its definition, mechanisms, and treatments.

Keywords: Amputation; Lower extremity; Neurologic mechanisms; Phantom limb pain; Therapeutics.

Copyright © 2018 Daping Hospital and the Research Institute of Surgery of the Third Military Medical University. Production and hosting by Elsevier B.V. All rights reserved.

References

    1. Dillingham T.R., Pezzin L.E., MacKenzie E.J. Limb amputation and limb deficiency: epidemiology and recent trends in the United States. South Med J. 2002;95:875–883.
    1. Owings M.F., Kozak L.J. Ambulatory and inpatient procedures in the United States, 1996. Vital Health Stat. 1998;13(139):1–119.
    1. Ziegler-Graham K., MacKenzie E.J., Ephraim P.L. Estimating the prevalence of limb loss in the United States: 2005 to 2050. Arch Phys Med Rehabil. 2008;89:422–429.
    1. Sherman R.A., Sherman C.J., Parker L. Chronic phantom and stump pain among American veterans: results of a survey. Pain. 1984;18:83–95.
    1. Jackson M.A., Simpson K.K. Pain after amputation. Cont Educ Anaesth Crit Care Pain. 2004;4:20–23. doi: 10.1093/bjaceaccp/mkh007.
    1. Nikolajsen L., Jensen T.S. Phantom limb pain. Br J Anaesth. 2001;87:107–116.
    1. Lemons M.L. Locate the lesion: a project-based learning case that stimulates comprehension and application of neuroanatomy. J Undergrad Neurosci Educ. 2017;15:C7–C10.
    1. Büntjen L., Hopf J.M., Merkel C. Somatosensory misrepresentation associated with chronic pain: spatiotemporal correlates of sensory perception in a patient following a complex Regional pain syndrome spread. Front Neurol. 2017;8:142.
    1. Srivastava D. Chronic post-amputation pain: peri-operative management - Review. Br J Pain. 2017;11:192–202.
    1. Kajander K.C., Wakisaka S., Bennett G.J. Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat. Neurosci Lett. 1992;138:225–228.
    1. Koga K., Li S., Zhuo M. Metabotropic glutamate receptor dependent cortical plasticity in chronic pain. Curr Neuropharmacol. 2016;14:427–434.
    1. Flor H., Elbert T., Knecht S. Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature. 1995;375:482–484.
    1. Lü Y.F., Yang Y., Li C.L. The Locus coeruleus-norepinephrine system mediates empathy for pain through selective up-regulation of P2X3 receptor in dorsal root ganglia in rats. Front Neural Circ. 2017;11:66.
    1. Bannister K., Kucharczyk M., Dickenson A.H. Hopes for the future of pain control. Pain Ther. 2017;6:117–128.
    1. Aydemir K., Demir Y., Güzelküçük Ü. Ultrasound findings of young and traumatic amputees with lower extremity residual limb pain in Turkey. Am J Phys Med Rehabil. 2017;96:572–577.
    1. Tang Y.Y., Lu Q., Fan M. Mechanisms of white matter changes induced by meditation. Proc Natl Acad Sci U S A. 2012;109:10570–10574.
    1. Zatorre R.J., Fields R.D., Johansen-Berg H. Plasticity in gray and white: neuroimaging changes in brain structure during learning. Nat Neurosci. 2012;15:528–536.
    1. Pons T.P., Garraghty P.E., Ommaya A.K. Massive cortical reorganization after sensory deafferentation in adult macaques. Science. 1991;252:1857–1860.
    1. Jiang G., Yin X., Li C. The plasticity of brain gray matter and white matter following lower limb amputation. Neural Plast. 2015;2015:823185.
    1. Klein M.M., Treister R., Raij T. Transcranial magnetic stimulation of the brain: guidelines for pain treatment research. Pain. 2015;156:1601–1614.
    1. Ramachandran V.S., Stewart M., Rogers-Ramachandran D.C. Perceptual correlates of massive cortical reorganization. Neuroreport. 1992;3:583–586.
    1. Sivan M., Stoppard E., Kirker S. Alteration in phantom pain and sensation with visceral movement. PM&R. 2010;2:576–578.
    1. Young E.E., Lariviere W.R., Belfer I. Genetic basis of pain variability: recent advances. J Med Genet. 2012;49:1–9.
    1. Latremoliere A., Costigan M. GCH1, BH4 and pain. Curr Pharmaceut Biotechnol. 2011;12:1728–1741.
    1. Kalso E., Tasmuth T., Neuvonen P.J. Amitriptyline effectively relieves neuropathic pain following treatment of breast cancer. Pain. 1996;64:293–302.
    1. Black L.M., Persons R.K., Jamieson B. Clinical inquiries. What is the best way to manage phantom limb pain? J Fam Pract. 2009;58:155–158.
    1. Katz J., Melzack R. Auricular transcutaneous electrical nerve stimulation (TENS) reduces phantom limb pain. J Pain Symptom Manag. 1991;6(2):73–83.
    1. Guenther K. It's all done with mirrors: V.S. Ramachandran and the material culture of phantom limb research. Med Hist. 2016;60(3):342–358.
    1. Chan B.L., Witt R., Charrow A.P. Mirror therapy for phantom limb pain. N Engl J Med. 2007;357(21):2206–2207.
    1. Ortiz-Catalan M., Sander N., Kristoffersen M.B. Treatment of phantom limb pain (PLP) based on augmented reality and gaming controlled by myoelectric pattern recognition: a case study of a chronic PLP patient. Front Neurosci. 2014;8:24.
    1. Subedi B., Grossberg G.T. Phantom limb pain: mechanisms and treatment approaches. Pain Res Treat. 2011;2011:864605.

Source: PubMed

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