Effectiveness of supplemental oxygenation to prevent surgical site infections: A systematic review with meta-analysis

Eduardo Tavares Gomes, Fábio da Costa Carbogim, Rossana Sant'Anna Lins, Ruy Leite de Melo Lins-Filho, Vanessa de Brito Poveda, Vilanice Alves de Araujo Püschel, Eduardo Tavares Gomes, Fábio da Costa Carbogim, Rossana Sant'Anna Lins, Ruy Leite de Melo Lins-Filho, Vanessa de Brito Poveda, Vilanice Alves de Araujo Püschel

Abstract

Objective: to assess the effectiveness of supplemental oxygenation with high FiO2 when compared to conventional FiO2 in the prevention of surgical site infection.

Method: an effectiveness systematic review with meta-analysis conducted in five international databases and portals. The research was guided by the following question: Which is the effectiveness of supplemental oxygenation with high FiO2 (greater than 80%) when compared to conventional FiO2 (from 30% to 35%) in the prevention of surgical site infections in adults?

Results: fifteen randomized clinical trials were included. Although all the subgroups presented a general effect in favor of the intervention, colorectal surgeries had this relationship evidenced with statistical significance (I2=10%;X2=4.42; p=0.352).

Conclusion: inspired oxygen fractions greater than 80% during the perioperative period in colorectal surgeries have proved to be effective to prevent surgical site infections, reducing their incidence by up to 27% (p=0.006). It is suggested to conduct new studies in groups of patients subjected to surgeries from other specialties, such as cardiac and vascular. PROSPERO registration No.: 178,453.

Conflict of interest statement

Conflict of interest: The authors have declared that there is no conflict of interest.

Figures

Figure 1. Flowchart corresponding to selection of…
Figure 1. Flowchart corresponding to selection of the articles that comprised the analysis corpus according to PRISMA. São Paulo, Brazil, 2021
Figure 4. Forest plot showing incidence and…
Figure 4. Forest plot showing incidence and relative risk of surgical site infections by subgroup (colorectal, cesarean and abdominal surgeries) when compared to high inspired oxygen fraction (FiO2>=80%) versus traditional supply (FiO2: 30%-35%). São Paulo, Brazil, 2021.

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