Burden of injuries avertable by a basic surgical package in low- and middle-income regions: a systematic analysis from the Global Burden of Disease 2010 Study

Hideki Higashi, Jan J Barendregt, Nicholas J Kassebaum, Thomas G Weiser, Stephen W Bickler, Theo Vos, Hideki Higashi, Jan J Barendregt, Nicholas J Kassebaum, Thomas G Weiser, Stephen W Bickler, Theo Vos

Abstract

Background: Injuries accounted for 11 % of the global burden of disease in 2010. This study aimed to quantify the burden of injury in low- and middle-income countries (LMICs) that could be averted if basic surgical services were made available and accessible to the entire population.

Methods: We examined all causes of injury from the Global Burden of Disease 2010 Study. We split the disability-adjusted life years (DALYs) for these conditions between surgically "avertable" and "nonavertable" burdens. For estimating the avertable fatal burden, we applied the lowest fatality rates among the 21 epidemiologic regions to each LMIC region, assuming that the differences in death rates between each region and the lowest rates reflect the gap in surgical care. We adjusted for fatal cases that occur prior to reaching hospitals as they are not surgically avertable. Similarly, we applied the lowest nonfatal burden per case to each LMIC region.

Results: Overall, 21 % of the injury burden in LMICs was potentially avertable by basic surgical care (52.3 million DALYs). The avertable proportion was greater for deaths than for nonfatal burden (23 vs. 20 %), suggesting that surgical services for injuries more effectively save lives than ameliorate disability. Sub-Saharan Africa had the largest proportion of potentially avertable burden (25 %). South Asia had the highest total avertable DALYs (17.4 million). Road injury comprised the largest total avertable burden in LMICs (16.1 million DALYs).

Conclusions: Basic surgical care has the potential to play a major role in reducing the injury-related burden in LMICs.

Figures

Fig. 1
Fig. 1
a Disability-adjusted life years (DALYs) by low- and middle-income (LMIC) super-region for all injuries combined. b Breakdown of surgically avertable burden in each LMIC super-region by cause of injury
Fig. 2
Fig. 2
a DALYs by cause of injury for all LMIC super regions combined. b Breakdown of surgically avertable burden for each cause of injury by LMIC super-region

References

    1. Murray CJL, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2197–2223. doi: 10.1016/S0140-6736(12)61689-4.
    1. Jamison D, Breman J, Measham A, et al., editors. Disease control priorities in developing countries. Washington, DC: World Bank; 2006.
    1. Debas H, Gosselin R, McCord C, et al. et al. Surgery. In: Jamison D, Breman J, Measham A, et al., editors. Disease control priorities in developing countries. Washington DC: World Bank; 2006.
    1. WHO . Surgical care at the district hospital. Geneva: World Health Organization; 2002.
    1. Mock C, Cherian M, Juillard C, et al. Developing priorities for addressing surgical conditions globally: furthering the link between surgery and public health policy. World J Surg. 2010;34:381–385. doi: 10.1007/s00268-009-0263-4.
    1. Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2095–2128. doi: 10.1016/S0140-6736(12)61728-0.
    1. Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1,160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2163–2196. doi: 10.1016/S0140-6736(12)61729-2.
    1. Salomon JA, Vos T, Hogan DR, et al. Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. Lancet. 2012;380:2129–2143. doi: 10.1016/S0140-6736(12)61680-8.
    1. Lehohla Pali. Road traffic accident deaths in South Africa, 2001–2006: evidence from death notification. Statistics South Africa: Pretoria; 2009.
    1. Singh Y, Das KC. An epidemiological study of road traffic accident victims in medicolegal autopsies. J Indian Acad Forensic Med. 2005;27:166–169.
    1. Gedeborg R, Chen LH, Thiblin I, et al. Prehospital injury deaths: strengthening the case for prevention—nationwide cohort study. J Trauma Acute Care Surg. 2012;72:765. doi: 10.1097/TA.0b013e3182288272.
    1. Wisborg T, Høylo T, Siem G. Death after injury in rural Norway: high rate of mortality and prehospital death. Acta Anaesthesiol Scand. 2003;47:153–156. doi: 10.1034/j.1399-6576.2003.00021.x.
    1. Tsegaye F, Abdella K, Ahmed E, et al. Pattern of fatal injuries in Addis Ababa, Ethiopia: a one-year audit. East Central Afr J Sur. 2010;15:10–17.
    1. Søreide K, Krüger AJ, Vårdal AL, et al. Epidemiology and contemporary patterns of trauma deaths: changing place, similar pace, older face. World J Surg. 2007;31:2092–2103. doi: 10.1007/s00268-007-9226-9.
    1. Roudsari B, Shadman M, Ghodsi M. Childhood trauma fatality and resource allocation in injury control programs in a developing country. BMC Public Health. 2006;6:117. doi: 10.1186/1471-2458-6-117.
    1. Masella CA, Pinho VF, Passos ADC, et al. Temporal distribution of trauma deaths: quality of trauma care in a developing country. J Trauma Acute Care Surg. 2008;65:653–658. doi: 10.1097/TA.0b013e3181802077.
    1. Arreola-Risa C, Mock C, Padilla D, et al. Trauma care systems in urban Latin America: the priorities should be prehospital and emergency room management. J Trauma Acute Care Surg. 1995;39:457–462. doi: 10.1097/00005373-199509000-00011.
    1. Bakke HK, Wisborg T. Rural high north: a high rate of fatal injury and prehospital death. World J Surg. 2011;35:1615–1620. doi: 10.1007/s00268-011-1102-y.
    1. Chiara O, Scott JD, Cimbanassi S, et al. Trauma deaths in an Italian urban area: an audit of pre-hospital and in-hospital trauma care. Injury. 2002;33:553–562. doi: 10.1016/S0020-1383(02)00123-7.
    1. Di Bartolomeo S, Sanson G, Michelutto V, et al. Epidemiology of major injury in the population of Friuli Venezia Giulia-Italy. Injury. 2004;35:391–400. doi: 10.1016/S0020-1383(03)00246-8.
    1. Hansen K, Morild I, Engesaeter L, et al. Epidemiology of severely and fatally injured patients in western part of Norway. Scand J Surg. 2004;93:198–203.
    1. Jayaraman S, Ozgediz D, Miyamoto J, et al. Disparities in injury mortality between Uganda and the United States: comparative analysis of a neglected disease. World J Surg. 2011;35:505–511. doi: 10.1007/s00268-010-0871-z.
    1. London J, Mock C, Abantanga FA, et al. Using mortuary statistics in the development of an injury surveillance system in Ghana. Bull World Health Organ. 2002;80:357–364.
    1. Leong M, Mujumdar S, Raman L, et al. Injury related deaths in Singapore. J Emerg Med. 2003;10:88–96.
    1. Mock CN, Jurkovich GJ, Arreola-Risa C, et al. Trauma mortality patterns in three nations at different economic levels: implications for global trauma system development. J Trauma Acute Care Surg. 1998;44:804–814. doi: 10.1097/00005373-199805000-00011.
    1. Sauaia A, Moore FA, Moore EE, et al. Epidemiology of trauma deaths: a reassessment. J Trauma Acute Care Surg. 1995;38:185–193. doi: 10.1097/00005373-199502000-00006.
    1. Demetriades D, Murray J, Sinz B, et al. Epidemiology of major trauma and trauma deaths in Los Angeles County. J Am Coll Surg. 1998;187:373. doi: 10.1016/S1072-7515(98)00209-9.
    1. Potenza BM, Hoyt DB, Coimbra R, et al. The epidemiology of serious and fatal injury in San Diego County over an 11-year period. J Trauma Acute Care Surg. 2004;56:68–75. doi: 10.1097/01.TA.0000101490.32972.9F.
    1. Baker CC, Oppenheimer L, Stephens B, et al. Epidemiology of trauma deaths. Am J Surg. 1980;140:144–150. doi: 10.1016/0002-9610(80)90431-6.
    1. Sills MR, Libby AM, Orton HD. Prehospital and in-hospital mortality: a comparison of intentional and unintentional traumatic brain injuries in Colorado children. Arch Pediatr Adolesc Med. 2005;159:665–670. doi: 10.1001/archpedi.159.7.665.
    1. Hussain L, Redmond A. Are pre-hospital deaths from accidental injury preventable? BMJ. 1994;308:1077–1080. doi: 10.1136/bmj.308.6936.1077.
    1. Murad M, Larsen S, Husum H. Prehospital trauma care reduces mortality: ten-year results from a time-cohort and trauma audit study in Iraq. Scand J Trauma Resusc Emerg Med. 2012;20:13. doi: 10.1186/1757-7241-20-13.
    1. Meel BL. Pre-hospital and hospital traumatic deaths in the former homeland of Transkei, South Africa. J Clin Forensic Med. 2004;11:6–11. doi: 10.1016/j.jcfm.2003.10.009.
    1. Ryan M, Stella J, Chiu H, et al. Injury patterns and preventability in prehospital motor vehicle crash fatalities in Victoria. Emerg Med. 2004;16:274–279. doi: 10.1111/j.1742-6723.2004.00622.x.
    1. Montazeri A. Road-traffic-related mortality in Iran: a descriptive study. Public Health. 2004;118:110–113. doi: 10.1016/S0033-3506(03)00173-2.
    1. Ngo AD, Rao C, Hoa NTP, et al. Road traffic related mortality in Vietnam: evidence for policy from a national sample mortality surveillance system. BMC Public Health. 2012;12:561. doi: 10.1186/1471-2458-12-561.
    1. VanRooyen M, Sloan E, Barrett J, et al. Outcome in an urban pediatric trauma system with unified prehospital emergency medical services care. Prehosp Disaster Med. 1995;10:19.
    1. Papadopoulos IN, Bonovas S, Kanakaris NK, et al. Alcohol and psychoactive drugs increased the pre-hospital mortality in 655 fall-related fatalities in Greece: a call for management protocols. Injury. 2012;43:1522–1526. doi: 10.1016/j.injury.2010.11.056.
    1. Murray CJL, Ezzati M, Flaxman AD, et al. GBD 2010: design, definitions, and metrics. Lancet. 2012;380:2063–2066. doi: 10.1016/S0140-6736(12)61899-6.
    1. Mock C, Joshipura M, Arreola-Risa C, et al. An estimate of the number of lives that could be saved through improvements in trauma care globally. World J Surg. 2012;36:959–963. doi: 10.1007/s00268-012-1459-6.
    1. Hardcastle T, Samuels C, Muckart D. An assessment of the hospital disease burden and the facilities for the in-hospital care of trauma in KwaZulu-Natal, South Africa. World J Surg. 2013;37:1550–1561. doi: 10.1007/s00268-012-1889-1.
    1. De Villiers M, De Villiers PJT. The knowledge and skills gap of medical practitioners delivering district hospital services in the Western Cape, South Africa. S Afr Fam Pract. 2006;48:16-16c.

Source: PubMed

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