A New Device for Thoracoscopic Cryoanalgesia in Pectus Excavatum Repair: Preliminary Single Center Experience

Michele Torre, Leila Mameli, Rachele Bonfiglio, Vittorio Guerriero, Lucia Derosas, Loredana Palomba, Nicola Disma, Michele Torre, Leila Mameli, Rachele Bonfiglio, Vittorio Guerriero, Lucia Derosas, Loredana Palomba, Nicola Disma

Abstract

Introduction: Cryoanalgesia has been recently described as alternative technique for immediate and persistent pain treatment after pectus excavatum repair. Cryoanalgesia has the potentiality to reduce analgesic consumption and length of hospitalization. However, cryoanalgesia has not been standardized yet: the previous reports describe different techniques and systems and include only small series. In Europe, no reports on cryoanalgesia for pectus repair have been published so far. Materials and Methods: This is a prospective single center pilot study performed in adolescents undergoing minimally invasive pectus excavatum repair with a new cryoanalgesia system, using a probe designed specifically for thoracoscopy. This new double lumen probe has the theoretical advantage of freezing only in its tip, so reducing the risk of complications. Results: Seven patients undergoing pectus excavatum repair were treated with cryoanalgesia performed with the new probe. No complications of cryoanalgesia were reported. Total consumption of morphine during hospital stay was between 0.1 and 0.35 mg/kg, with no side effects reported. Mean time to discharge was 2.4 days. All patients reported a good pain control with a fair need of rescue medications for pain relief during the first week after discharge, and a very good pain control without need of rescue medications during following weeks. Conclusions: Our pilot study showed that the new cryoanalgesia device is efficacious in terms of pain control, hospital stay and resumption of post-operative activities. The cryoprobe designed allowed an easy and safe maneuver. A prospective trial is needed to better define the risks and benefits of this technique.

Keywords: MIRPE; cryoanalgesia; pectus excavatum; post-operative pain; thoracic surgery.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2021 Torre, Mameli, Bonfiglio, Guerriero, Derosas, Palomba and Disma.

Figures

Figure 1
Figure 1
The cryoanalgesia probe with the double cannula, which allows the creation of the ice ball just at the tip of the probe.
Figure 2
Figure 2
Thoracoscopic view of the ice ball.
Figure 3
Figure 3
Probe insertion through a 5 mm. Trocar placed at the site of surgical incision.
Figure 4
Figure 4
Trocarless percutaneous probe insertion in a medial position.

References

    1. Nuss D, Kelly RE, Jr, Croitoru DP, Katz ME. A 10-year review of a minimally invasive technique for the correction of pectus excavatum. J Pediar Surg. (1998) 33:545–52. 10.1016/S0022-3468(98)90314-1
    1. Singhal NR, Jerman JD. A review of anesthetic considerations and postoperative pain control after the Nuss procedure. Semin Pediatr Surg. (2018) 27:156–60. 10.1053/j.sempedsurg.2018.05.010
    1. Stroud AM, Tulanont DD, Coates TE, Goodney PP, Croitoru DP. Epidural analgesia versus intravenous patient-controlled analgesia following minimally invasive pectus excavatum repair: a systematic review and meta-analysis. J Pediatr Surg. (2014) 49:798–806. 10.1016/j.jpedsurg.2014.02.072
    1. Kim S, Idowu O, Palmer B, Lee SH. Use of transthoracic cryoanalgesia during the Nuss procedure. J Thorac Cardiovasc Surg. (2016) 151:887–8. 10.1016/j.jtcvs.2015.09.110
    1. Sancheti M. Freeze the pain away: the role of cryoanalgesia during a Nuss procedure. J Thorac Cardiovasc Surg. (2016) 151:889–90. 10.1016/j.jtcvs.2015.11.001
    1. Keller BA, Kabagambe SK, Becker JC, Chen YJ, Goodman LF, Clark-Wronski JM, et al. . Intercostal nerve cryoablation versus thoracic epidural catheters for postoperative analgesia following pectus excavatum repair: preliminary outcomes in twenty-six cryoablation patient. J Pediatr Surg. (2016) 51:2033–8. 10.1016/j.jpedsurg.2016.09.034
    1. Moorjani N, Zhao F, Tian Y, Liang C, Kaluba J, Maiwand MO. Effects of cryoanalgesia on post-thoracothomy pain on the structure of intercostal nerves: a human prospective randomized trial and a histological study. Eur J Cardiothorac Surg. (2001) 20:502–7. 10.1016/S1010-7940(01)00815-6
    1. Graves C, Idowu O, Lee S, Padilla B, Kim S. Intraoperative cryoanalgesia for managing pain after the Nuss procedure. J Pediatr Surg. (2017) 52:920–4. 10.1016/j.jpedsurg.2017.03.006
    1. Harbaugh CM, Johnson KN, Kein CE, Jarboe MD, Hirschl RB, Geiger JD, et al. . Comparing outcomes with thoracic epidural and intercostal nerve cryoablation after Nuss procedure. J Surg Res. (2018) 231:217–23. 10.1016/j.jss.2018.05.048
    1. Sujka J, Benedict LA, Fraser JD, Aguayo P, Millspaugh DL, St Peter SD. Outcomes using cryoablation for postoperative pain control in children following minimally invasive pectus excavatum repair. J Laparoendosc Adv Surg Tech A. (2018) 28:1383–6. 10.1089/lap.2018.0111
    1. Graves CE, Moyer J, Zobel MJ, Mora R, Smith D, O'Day M, et al. . Intraoperative intercostal nerve cryoablation during the Nuss procedure reduces length of stay and opioid requirement: a randomized clinical trial. J Pediatr Surg. (2019) 54:2250–6. 10.1016/j.jpedsurg.2019.02.057
    1. Dekonenko C, Dorman RM, Duran Y, Juang D, Aguayo P, Fraser JD, et al. Postoperative pain control modialities for pectus excavatum repair: a prospective observational study of cryoablation compared to results of a randomized of epidural vs. patient-controlled analgesia. J Pediatr Surg. (2020) 55:1444–7. 10.1016/j.jpedsurg.2019.09.021
    1. Cadaval Gallardo C, Martinez J, Bellia-Munzon G, Nazar M, Sanjurjo D, Toselli L, et al. . Thoracoscopic cryoanalgesia: a new strategy for postoperative pain control in minimally invasive pectus excavatum repair. Cir Pediatr. (2020) 33:11–15.
    1. Holley AL, Zhou C, Wilson AC, Hainsworth K, Palermo TM. The CALI-9: a brief measure for assessing activity limitations in children and adolescents with chronic pain. Pain. (2018) 159:48–56. 10.1097/j.pain.0000000000001063
    1. Torre M, Guerriero V, Wong MCY, Palo F, Lena F, Mattioli G. Complications and trends in minimally invasive repair of pectus excavatum: a large volume, single institution experience. J Pediatr Surg. (2020) 10.1016/j.jpedsurg.2020.11.027
    1. Parrado R, Lee J, McMahon LE, Clay C, Powell J, Kang P, et al. . Cryoanalgesia in pectus excavatum: lessons learned. J Laparoendosc Adv Surg Techn. (2019) 10:1244–51. 10.1089/lap.2019.0203
    1. Morikawa N, Laferriere N, Koo S, Johnson S, Woo R, Puapong D. Cryoanalgesia in patients undergoing Nuss repair of pectus excavatum: technique modifications and early results. J Laparosc Adv Surg Techn A. (2018) 9:1148–51. 10.1089/lap.2017.0665
    1. Stondell CR, Sundeep ST, Raff GW, Rahm AL. A novel approach to pain management for the Nuss procedure using erector spinae plane blockade and cryoanalgesia. Int J Anesth Res. (2020) 7:584–8. 10.19070/2332-2780-20000116

Source: PubMed

3
Iratkozz fel