Therapeutic Role of Mango Peels in Management of Dyslipidemia and Oxidative Stress in Obese Females

Farkhanda Arshad, Huma Umbreen, Iqra Aslam, Arruje Hameed, Kiran Aftab, Wahidah H Al-Qahtani, Nighat Aslam, Razia Noreen, Farkhanda Arshad, Huma Umbreen, Iqra Aslam, Arruje Hameed, Kiran Aftab, Wahidah H Al-Qahtani, Nighat Aslam, Razia Noreen

Abstract

Obesity is a chronic metabolic and noncommunicable disease that affects 50% of world population. Reactive oxygen species and oxidative stress are interconnected with the obesity and several metabolic disorders, gaining the attention of scientific community to combat this problem naturally. Among various fruits, mango as a yellow fruit is rich in polyphenols, carotenoids, terpenes, and flavonoids that act as antioxidants to protect against free radicals produced in the body. The present study was performed to explore in vivo antioxidant potential of mango peels against dyslipidemia and oxidative stress in overweight subjects. The female volunteers (n = 31) between 25 and 45 years of age having a body mass index (BMI) of 25.0-29.9 (overweight) were included in this study, while participants with complications as diabetes, hypertension, cardiovascular, and liver diseases were excluded. The treatment group consumed 1 g mango peel powder for 84 days. The subjects were analyzed for biochemical analysis, antioxidant status, and anthropometric measurements at baseline and end of the study period. Further, at the end of study, the safety evaluation tests were also performed. The results showed that upon consumption of mango peel powder, low-density lipoproteins (LDL), cholesterol, triglyceride, urea, and creatinine levels were decreased and high-density lipoprotein (HDL) level was increased (P ≤ 0.05), while thiobarbituric acid reactive substances (TBARS) showed increased antioxidant status (P ≤ 0.05) which suggests that mango peels have a strong management potential against oxidative stress and dyslipidemia in obese subjects.

Conflict of interest statement

The authors declare no conflict of interest.

Copyright © 2021 Farkhanda Arshad et al.

Figures

Figure 1
Figure 1
HPLC chromatogram of phenolic compounds of the mango peel extract. Peak identification of mango peel extract: 2, kaempherol; 3, quercetin; 6, gallic acid; 8, caffeic acid; 9, chlorogenic acid; 11, vitamin C; and 12, sinapicacid.
Figure 2
Figure 2
Effect of treatment days on the BMI value of obese subjects in the control and MPP-treated groups.
Figure 3
Figure 3
Reduction in the TBARS (μmol/mL ±SEM) value with increase in treatment days.

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