Gastric mucosal changes caused by Lugol's iodine solution spray: endoscopic features of 64 cases on screening esophagogastroduodenoscopy

Daisuke Tsurumaru, Takashi Utsunomiya, Shuji Matsuura, Masahiro Komori, Satoshi Kawanami, Tatsuyuki Ishibashi, Hiroshi Honda, Daisuke Tsurumaru, Takashi Utsunomiya, Shuji Matsuura, Masahiro Komori, Satoshi Kawanami, Tatsuyuki Ishibashi, Hiroshi Honda

Abstract

Aim: To clarify the endoscopic mucosal change of the stomach caused by Lugol's iodine solution spray on screening esophagogastroduodenoscopy (EGD).

Methods: Sixty-four consecutive patients who underwent EGD for esophageal squamous cell carcinoma screening were included in this study. The records for these patients included gastric mucosa findings before and after Lugol's iodine solution was sprayed. The endoscopic findings of the greater curvature of the gastric body were retrospectively analyzed based on the following findings: fold thickening, exudates, ulcers, and hemorrhage.

Results: Mucosal changes occurred after Lugol's solution spray totally in 51 patients (80%). Fold thickening was observed in all 51 patients (80%), and a reticular pattern of white lines was found on the surface of the thickened gastric folds found in 28 of the patients (44%). Exudates were observed in 6 patients (9%).

Conclusion: The gastric mucosa could be affected by Lugol's iodine; the most frequent endoscopic finding of this effect is gastric fold thickening, which should not be misdiagnosed as a severe gastric disease.

Figures

Figure 1
Figure 1
Gastric mucosal changes occurred after splaying Lugol's iodine solution in a 78-year-old man. (a) Endoscopic view of the greater curvature of the gastric body showed no fold thickening. (b) Endoscopic view after spraying Lugol's iodine solution showed fold thickening.
Figure 2
Figure 2
Gastric mucosal changes caused by Lugol's solution in a 58-year-old man. The reticular pattern of white lines on the thickened folds is shown by the arrows.

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Source: PubMed

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