Muscle oxygen consumption by NIRS and mobility in multiple sclerosis patients

Anna Maria Malagoni, Michele Felisatti, Nicola Lamberti, Nino Basaglia, Roberto Manfredini, Fabrizio Salvi, Paolo Zamboni, Fabio Manfredini, Anna Maria Malagoni, Michele Felisatti, Nicola Lamberti, Nino Basaglia, Roberto Manfredini, Fabrizio Salvi, Paolo Zamboni, Fabio Manfredini

Abstract

Background: The study of muscle metabolism by near-infrared spectroscopy (NIRS) has been poorly implemented in multiple sclerosis (MS). Aims of the study were to compare resting muscle oxygen consumption (rmVO2) at gastrocnemius in MS patients and in age-matched healthy controls (HC) measured using NIRS, and to evaluate its possible relationship with patients' mobility.

Methods: Twenty-eight consecutively enrolled MS patients (male, n = 16; age = 42.7 ± 14.0 y, Relapsing-Remitting, n = 19; Primary-Progressive, n = 9) and 22 HC (male, n = 13; age = 36.0 ± 8.2 y) were studied during rest applying the NIRS probes at gastrocnemius, producing a venous occlusion at the thigh using a cuff, and analyzing the slope of the total hemoglobin to calculate rmVO2. Mobility was assessed by a 6-Minute Walking Test and 6-Minute Walking Distance (6MWD) was recorded.

Results: rmVO2 was higher in MS compared to HC (0.059 ± 0.038 vs 0.039 ± 0.016 mlO2/min/100 g, P < 0.003), not different in clinical subtypes, not correlated to patients' characteristics (age, disease duration, Expanded Disability Status Scale, resting heart rate, skinfold thickness), and significantly higher in patients with lower walking ability (6MWD < 450 m, n = 12) compared to those at better performance (respectively, 0.072 ± 0.043 vs 0.049 ± 0.032 mlO2/min/100 g, P = 0.03).

Conclusion: rmVO2 values, significantly higher in MS patients compared to HC, and in low versus high performing patients, might represent a marker of peripheral adaptations occurred to sustain mobility, as observed in other chronic diseases.

Figures

Figure 1
Figure 1
Comparison between rmVO2 values of legs of healthy and MS subjects. Legend to figure: rmVO2, resting muscle oxygen consumption; HC, healthy controls, MS, Multiple Sclerosis; RR, Relapsing Remitting; PP, Primary Progressive. Statistical analysis: Unpaired Student T-test between HC and all MS; One-way ANOVA among HC, RR, and PP.
Figure 2
Figure 2
Comparison between rmVO2 values of legs of MS population ranked according to mobility. Values of healthy controls were also included. Legend to figure: rmVO2, resting muscle oxygen consumption; MS, Multiple Sclerosis; HC, healthy controls. Statistical analysis: Unpaired Student T-test between MS low and high mobility; One-way ANOVA among MS low and high mobility, and HC.

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Source: PubMed

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