Young Women With Breast Cancer in Mexico: Results of the Pilot Phase of the Joven & Fuerte Prospective Cohort

Cynthia Villarreal-Garza, Alejandra Platas, Melina Miaja, Alan Fonseca, Fernanda Mesa-Chavez, Marisol Garcia-Garcia, Judy-Anne Chapman, Edna A Lopez-Martinez, Claudia Pineda, Alejandro Mohar, Carmen L Galvez-Hernandez, Andrea Castro-Sanchez, Bertha-Alejandra Martinez-Cannon, Regina Barragan-Carrillo, Jose F Muñoz-Lozano, Paul Goss, Juan E Bargallo-Rocha, Dione Aguilar, Servando Cardona, Mauricio Canavati, Cynthia Villarreal-Garza, Alejandra Platas, Melina Miaja, Alan Fonseca, Fernanda Mesa-Chavez, Marisol Garcia-Garcia, Judy-Anne Chapman, Edna A Lopez-Martinez, Claudia Pineda, Alejandro Mohar, Carmen L Galvez-Hernandez, Andrea Castro-Sanchez, Bertha-Alejandra Martinez-Cannon, Regina Barragan-Carrillo, Jose F Muñoz-Lozano, Paul Goss, Juan E Bargallo-Rocha, Dione Aguilar, Servando Cardona, Mauricio Canavati

Abstract

Purpose: The pilot-phase report of the Joven & Fuerte prospective cohort broadly characterizes and assesses the needs of Mexican young women with breast cancer (YWBC).

Patients and methods: Women age ≤ 40 years with nonmetastatic primary breast cancer were consecutively accrued from 2 hospitals. Data were collected at the first/baseline oncology visit and 2 years later using a sociodemographic survey, European Organisation for Research and Treatment of Cancer Quality-of-Life (QOL) Questionnaire Core 30 (QLQ-C30) and Breast Cancer-Specific QOL Questionnaire (QLQ-BR23), Hospital Anxiety and Depression Scale (HADS), Female Sexual Functioning Index (FSFI), Sexual Satisfaction Inventory, and patients' medical records. Pearson χ2 and 2-sided t tests were used for statistical analysis. An unadjusted P value < .05 was considered significant.

Results: Ninety patients were included, all with government health care coverage. Most had low monthly household incomes (98%) and at least a high school education (59%). There was a considerable prevalence of unpartnered patients (36%) and unmet parity (25%). Patients' most common initial symptom was a palpable mass (84%), and they were most frequently diagnosed with stage III disease (48%), with 51% having had a physician visit ≤ 3 months since detection but 39% receiving diagnosis > 12 months later. At baseline, 66% of patients were overweight/obese, and this proportion had significantly increased by 2 years (P < .001). Compared with baseline, global QLQ-C30 had improved significantly by 2 years (P = .004), as had HADS-Anxiety (P < .001). However, both at baseline and at 2 years, nearly half of patients exhibited FSFI sexual dysfunction.

Conclusion: These preliminary findings demonstrate that YWBC in Mexico have particular sociodemographic and clinicopathologic characteristics, reinforcing the necessity to further describe and explore the needs of these young patients, because they may better represent the understudied and economically vulnerable population of YWBC in limited-resource settings.

Conflict of interest statement

Cynthia Villarreal-Garza

Consulting or Advisory Role: Roche, Novartis, Pfizer, Eli Lilly

Speakers’ Bureau: Roche, Myriad Genetics, Novartis

Research Funding: AstraZeneca (Inst), Roche (Inst)

Travel, Accommodations, Expenses: Roche, MSD Oncology, Pfizer

No other potential conflicts of interest were reported.

Figures

FIG 1
FIG 1
Flow diagram of study.

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Source: PubMed

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