Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue
Emma E Tarttelin, James Bellingham, Mark W Hankins, Russell G Foster, Robert J Lucas, Emma E Tarttelin, James Bellingham, Mark W Hankins, Russell G Foster, Robert J Lucas
Abstract
We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord.
Source: PubMed