Post-stroke Hemiplegic Gait: New Perspective and Insights

Sheng Li, Gerard E Francisco, Ping Zhou, Sheng Li, Gerard E Francisco, Ping Zhou

Abstract

Walking dysfunction occurs at a very high prevalence in stroke survivors. Human walking is a phenomenon often taken for granted, but it is mediated by complicated neural control mechanisms. The automatic process includes the brainstem descending pathways (RST and VST) and the intraspinal locomotor network. It is known that leg muscles are organized into modules to serve subtasks for body support, posture and locomotion. Major kinematic mechanisms are recognized to minimize the center of gravity (COG) displacement. Stroke leads to damage to motor cortices and their descending corticospinal tracts and subsequent muscle weakness. On the other hand, brainstem descending pathways and the intraspinal motor network are disinhibited and become hyperexcitable. Recent advances suggest that they mediate post-stroke spasticity and diffuse spastic synergistic activation. As a result of such changes, existing modules are simplified and merged, thus leading to poor body support and walking performance. The wide range and hierarchy of post-stroke hemiplegic gait impairments is a reflection of mechanical consequences of muscle weakness, spasticity, abnormal synergistic activation and their interactions. Given the role of brainstem descending pathways in body support and locomotion and post-stroke spasticity, a new perspective of understanding post-stroke hemiplegic gait is proposed. Its clinical implications for management of hemiplegic gait are discussed. Two cases are presented as clinical application examples.

Keywords: botulinum toxin; gait; hemiparesis; motor recovery; spasticity; stroke.

Figures

Figure 1
Figure 1
Altered neural control for post-stroke gait. CST, corticospinal tract; RST, reticulospinal tract; VST, vestibulospinal tract.
Figure 2
Figure 2
(A,B) A stroke survivor with spasticity that resulted in dramatic trunk lateral flexion and hip hiking before and after botulinum toxin injections; (C,D) A stroke survivor with spasticity that resulted in dynamic hip adduction and pelvic anterior rotation before and after botulinum toxin injection. See text for details.

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