Incidence and risk factors of congenital heart disease in Qingdao: a prospective cohort study

Xiao Jin, Wei Ni, Guolan Wang, Qin Wu, Jun Zhang, Guoju Li, Na Jiao, Wenjing Chen, Qing Liu, Li Gao, Quansheng Xing, Xiao Jin, Wei Ni, Guolan Wang, Qin Wu, Jun Zhang, Guoju Li, Na Jiao, Wenjing Chen, Qing Liu, Li Gao, Quansheng Xing

Abstract

Background: Many studies have been conducted to assess the incidence of congenital heart disease (CHD). However, results were greatly inconsistent among these studies with a broad range of findings.

Methods: A prospective census-based cohort study was conducted in Qingdao, China, from August 1, 2018 to April 30, 2019. All of the local registered pregnant women were continuously investigated and followed from 15 to 20 weeks of gestation to delivery, tracking the CHD cases in both the fetal and neonatal stages. A logistic regression model was applied to assess the association between CHD and possible risk factors.

Results: The positive rate of prenatal CHD screening was 14.36 per 1000 fetuses and the incidence of CHD was 9.38 per 1000 live births. Results from logistic regression indicated that, living in the countryside (odds ratio, (OR): 0.771; 95% confidence interval, (CI): 0.628-0.946) and having a childbearing history (OR: 0.802; 95%CI: 0.676-0.951) were negatively associated with CHD. However, twin pregnancy (OR: 1.957, 95% CI: 1.245-3.076), illness in the first trimester (OR: 1.306; 95% CI: 1.048-1.628), a family history of CHD (OR: 7.156; 95% CI: 3.293-15.552), and having a child with a birth defect (OR: 2.086; 95% CI: 1.167-3.731) were positively associated with CHD.

Conclusion: CHD is a serious health problem in Qingdao. The CHD incidence found in this study was similar to existing research. The positive rate of prenatal CHD screening was higher than the incidence of neonatal CHD. Moreover, CHD risk factors were identified in our study, and our findings may have great implications for formation CHD intervention strategies.

Keywords: Congenital heart defects; Epidemiologic studies; Incidence; Regression analysis; Risk factors.

Conflict of interest statement

The author declares to have no competing interests.

Figures

Fig. 1
Fig. 1
The distribution of screened CHD cases from the fetal to the neonatal stage
Fig. 2
Fig. 2
The incidence and proportion of CHD
Fig. 3
Fig. 3
Results of univariate logistic regression analysis
Fig. 4
Fig. 4
Results of multivariable logistic regression model

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Source: PubMed

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