Preliminary results of the cross-sectional associations of sedentary behavior and physical activity with serum brain-derived neurotrophic factor in adults with coronary heart disease

Antje Ullrich, Kristin Wenzel, Martin Bahls, Lisa Voigt, Stephanie Könemann, Marcus Dörr, Susanne Wurm, Sabina Ulbricht, Antje Ullrich, Kristin Wenzel, Martin Bahls, Lisa Voigt, Stephanie Könemann, Marcus Dörr, Susanne Wurm, Sabina Ulbricht

Abstract

This is the first study to analyze the association of accelerometer-measured patterns of habitual physical activity (PA) and sedentary behavior (SB) with serum BDNF in individuals with coronary heart disease. A total of 30 individuals (M = 69.5 years; 80% men) participated in this pre-post study that aimed to test a multi-behavioral intervention. All participants underwent standardized measurement of anthropometric variables, blood collection, self-administered survey, and accelerometer-based measurement of PA and SB over seven days. Serum BDNF concentrations were measured using enzyme-linked immunosorbent assay kit. We applied separate multiple linear regression analysis to estimate the associations of baseline SB pattern measures, light and moderate-to-vigorous PA with serum BDNF (n = 29). Participants spent 508.7 ± 76.5 min/d in SB, 258.5 ± 71.2 min/d in light PA, and 21.2 ± 15.2 min/d in moderate-to-vigorous PA. Per day, individuals had 15.5 ± 3.2 numbers of 10-to-30 min bouts of SB (average length: 22.2 ± 2.1 min) and 3.4 ± 1.2 numbers of > 30 min bouts of SB (average length: 43.8 ± 2.4 min). Regression analysis revealed no significant associations between any of the accelerometer-based measures and serum BDNF. The findings of this study did not reveal an association of accelerometer-measured PA and SB pattern variables with serum BDNF in individuals with coronary heart disease. In addition, our data revealed a considerable variation of PA and SB which should be considered in future studies.

Conflict of interest statement

The authors declare no competing interests.

© 2022. The Author(s).

Figures

Figure 1
Figure 1
Total time spent in sedentary behavior, light physical activity, and moderate-to-vigorous physical activity among individuals with coronary heart disease (n = 29). Note. SB = Sedentary behavior, LPA = Light physical activity, MVPA = Moderate-to-vigorous physical activity, BDNF = Brain-derived neurotrophic factor. The dark grey segments represent the time spent in SB, the light grey segments represent the time spent in LPA, and the black segments represent the time spent in MVPA. Individuals are ranked by values of BDNF (ng/ml).

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Source: PubMed

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