Modulation of the autonomic nervous system by one session of spinal low-level laser therapy in patients with chronic colonic motility dysfunction

M Khawar Ali, Shrayasee Saha, Natalija Milkova, Lijun Liu, Kartik Sharma, Jan D Huizinga, Ji-Hong Chen, M Khawar Ali, Shrayasee Saha, Natalija Milkova, Lijun Liu, Kartik Sharma, Jan D Huizinga, Ji-Hong Chen

Abstract

Patients with a defecation disorder may not evoke a normal defecation reflex, or the reflex may be excessive, as a dysfunction of the spinal autonomic nervous system. Treatment with various forms of lumbar and sacral neuromodulation have shown symptom improvement, but potential changes in autonomic functioning are rarely studied. Here we evaluate the effects on autonomic function of a single session of low-level laser therapy (LLLT) on the lumbar and sacral spine in 41 patients with chronic gastrointestinal motor dysfunction. The LLLT protocol used red LED light at a wavelength of 660 nm for 10 min and infrared LED light at a wavelength of 840 nm for 10 min, followed by infrared laser light at a wavelength of 825 nm for 10 min. Effects on the autonomic nervous system were assessed by measuring heart rate variability (HRV) changes. Respiratory Sinus Arrhythmia (RSA) and Root Mean Square of Successive Differences (RMSSD) were used to quantify parasympathetic reactivity; the Baevsky's Stress Index (SI) reflected sympathetic activity while the ratios SI/RSA and SI/RMSSD were used to show shifts in autonomic dominance. The results indicate that lumbar and sacral neuromodulation using light arrays reduced, whereas stimulation by the laser probes significantly increased parasympathetic activity. The light arrays increased whereas the laser probes significantly decreased sympathetic activity (SI). The entire protocol shifted the autonomic balance toward parasympathetic activity. The comparison of actual vs. sham neuromodulation proved that the change in HRV parameters was due to actual light stimulation and not due to the arrays and probe touching the skin. In conclusion, a single session of LLLT markedly affects autonomic nervous system activity reflected in changes in HRV which is only possible by generating activity in the spinal autonomic nerves. These results warrant a study into the effects of LLLT on restoring autonomic dysfunction in chronic refractory colonic motility disorders.

Keywords: Baevsky stress index; autonomic nervous system; constipation; low level laser (light) therapy (LLLT); respiratory sinus arrhythmia; sacral neuromodulation.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Copyright © 2022 Ali, Saha, Milkova, Liu, Sharma, Huizinga and Chen.

Figures

FIGURE 1
FIGURE 1
(A) LED array placements A, B, C, and D. (B) Target areas for laser probe stimulation marked as red dots. Each point is stimulated for 20 seconds. Basic image obtained from dreamstime.com with permission.
FIGURE 2
FIGURE 2
Autonomic nervous system modulation as deduced from HRV changes during one session of low-level laser therapy, stimulating the lumbar and sacral spine. (A) RSA, (B) RMSSD, (C) SI, (D) SI/RSA, (E) SI/RMSSD, (F) HR. Average values ± SEM from 41 patients with chronic colonic motility dysfunction.
FIGURE 3
FIGURE 3
Change in RSA, SI, and SI/RSA due to laser probe stimulation and recovery in all 41 patients.
FIGURE 4
FIGURE 4
Autonomic nervous system modulation as deduced from HRV changes during the entire protocol of one session of low-level laser therapy in one patient. (A) RR Intervals time series, (B) HF band power, (C) RMSSD, (D) SI.
FIGURE 5
FIGURE 5
Autonomic nervous system modulation as deduced from HRV changes during one session of low-level laser therapy, stimulating the lumbar and sacral spine. (A) RSA, (B) RMSSD, (C) SI, (D) SI/RSA, (E) SI/RMSSD, (F) HR. Average values ± SEM from 6 healthy subjects during sham (placement of arrays and probe but no stimulation) and during actual activation of the arrays and probe.
FIGURE 6
FIGURE 6
Comparison of autonomic nervous system activity during the application of the probe procedure with and without (sham) activating the probe. (A) RR Intervals time series, (B) HF band power, (C) RMSSD, (D) SI.

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