Global prevalence of visual impairment associated with myopic macular degeneration and temporal trends from 2000 through 2050: systematic review, meta-analysis and modelling

Abstract

Purpose: We used systematic review and meta-analysis to identify and assimilate evidence quantifying blindness and visual impairment (VI) associated with myopic macular degeneration (MMD), then derived models to predict global patterns. The models were used to estimate the global prevalence of blindness and VI associated with MMD from 2000 to 2050.

Methods: The systematic review identified 17 papers with prevalence data for MMD VI fitting our inclusion criteria. Data from six papers with age-specific data were scaled to relative age-dependent risk and meta-analysed at VI and blindness levels. We analysed variance in all MMD VI and blindness data as a proportion of high myopia against variables from the place and year of data collection, with a model based on health expenditure providing the best correlation. We used this model to estimate the prevalence and number of people with MMD VI in each country in each decade.

Results: We included data from 17 studies comprising 137 514 participants. We estimated 10.0 million people had VI from MMD in 2015 (prevalence 0.13%, 95% CI 5.5 to 23.7 million, 0.07% to 0.34%), 3.3 million of whom were blind (0.04%, 1.8 to 7.8 million, 0.03% to 0.10%). We estimate that by 2050, without changing current interventions, VI from MMD will grow to 55.7 million people (0.57%, 29.0 to 119.7 million, 0.33% to 1.11%), 18.5 million of whom will be blind (0.19%, 9.6 to 39.7 million, 0.11% to 0.37%).

Conclusion: The burden of MMD blindness and VI will rise significantly without efforts to reduce the development and progression of myopia and improve the management of MMD.

Keywords: blindness; macular degeneration; myopia; prevalence; visual impairment.

Conflict of interest statement

Competing interests: The authors have no relevant proprietary interests. TRF: consultant for Brien Holden Vision Institute. MJ: no financial disclosures. KSN: no financial disclosures. PS: no financial disclosures. TN: no financial disclosures. SMH: no financial disclosures. TYW: consultant and on advisory boards for Allergan, Bayer and Novartis. SR: consultant for Brien Holden Vision Institute and previously worked for Thea Pharmaceuticals (2008-2010).

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Figures

Figure 1

Flow diagram summarising the systematic search, using medical subject headings (MeSH) terms, and review process for identifying evidence on the prevalence of MMD VI and/or blindness. Our inclusion criteria were population-based or blindness registry studies quantifying prevalence, with sampling representative of whole communities. Exclusion criteria were unspecified or ambiguous definitions, not specifying the number of eligible participants, participation rate

Figure 2

The age distribution of global blindness associated with myopic macular degeneration (MMD) in 2000 and 2050. Both age-specific global prevalence (top) and the number of people predicted to be blind (bottom) are shown.

Figure 3

Predicted prevalence of, and number of people with, blindness and visual impairment (VI) associated with myopic macular degeneration (MMD) for each decade in 2000–2050. The top graph shows the crude all-ages prevalence of blindness (triangles and dashed line) and VI (squares with solid line) associated with MMD. The bottom graph shows the number of people with blindness (striped columns) and VI (unfilled columns) associated with MMD. Error bars represent 95% CIs.