Effect of vitamin E on Semen Quality Parameters: A Meta-Analysis of a Randomized Controlled Trial
Rui Wang, Shangren Wang, Yuxuan Song, Hang Zhou, Yang Pan, Li Liu, Shuai Niu, Xiaoqiang Liu, Rui Wang, Shangren Wang, Yuxuan Song, Hang Zhou, Yang Pan, Li Liu, Shuai Niu, Xiaoqiang Liu
Abstract
Purpose: To explore the effectiveness of vitamin E in male infertility, a systematic review and meta-analysis was conducted.
Materials and methods: The retrieval time was from January 1947 to May 2021, without language restriction. Stata 12.0 was used for the meta-analysis.
Results: A total of 8 randomized controlled trials involving 459 patients were included. The results showed that after vitamin E treatment, semen volume was reduced (95% CI: - 0.55 to - 0.06, SMD = - 0.30, p = 0.015), total sperm count was increased (95% CI: 0.02-0.45, SMD = 0.23, p = 0.035), and the differences were statistically significant. There were no statistically significant differences in increasing sperm concentration (95% CI: -0.21-0.29, SMD = 0.04, p = 0.769), total sperm motility (95% CI: -0.01-0.42, SMD = 0.20, p = 0.061) or sperm forward motility rate (95% CI: -0.06-0.65, SMD = 0.29, p = 0.106). Subgroup analysis showed that vitamin E treatment for six months could improve sperm forward motility (95% CI: 0.46-1.14, SMD = 0.80, p <0.001).
Conclusion: Vitamin E could increase the total sperm count and reduce the volume of semen in male infertility patients, and long-term treatment could improve the forward motility rate of sperm. The decrease of semen volume may be the result of different abstinence time before and after the test.
Source: PubMed