Outcome of Medically Versus Surgically Treated Patients With Chronic Thromboembolic Pulmonary Hypertension
Maria Wieteska, Andrzej Biederman, Marcin Kurzyna, Wojciech Dyk, Janusz Burakowski, Liliana Wawrzyńska, Monika Szturmowicz, Anna Fijałkowska, Piotr Szatkowski, Adam Torbicki, Maria Wieteska, Andrzej Biederman, Marcin Kurzyna, Wojciech Dyk, Janusz Burakowski, Liliana Wawrzyńska, Monika Szturmowicz, Anna Fijałkowska, Piotr Szatkowski, Adam Torbicki
Abstract
Chronic thromboembolic pulmonary hypertension (CTEPH) is an ominous disease leading to progressive right heart failure. Selected patients can be treated by pulmonary endarterectomy (PEA). We assessed long-term clinical outcome of patients with CTEPH who underwent PEA and patients who remained on medical treatment alone. A total of 112 consecutive patients with CTEPH referred between 1998 and 2008 to one center were followed for a mean of 35 (range 0-128) months after diagnosis. All the patients had advanced pulmonary hypertension at baseline. The operated group had higher World Health Organization functional class compared to the nonoperated group. No other differences in hemodynamic, echocardiographic, or biochemical parameters were observed at baseline. Despite the perioperative mortality rate of 9.1%, patients who underwent PEA had significantly lower long-term mortality compared to nonoperated patients (12.7% vs 34.8%; P = .003), and PEA survivors showed sustained clinical improvement. All efforts should be undertaken to perform PEA in all patients with operable CTEPH.
Keywords: prognostic factors; pulmonary endarterectomy; pulmonary hypertension; pulmonary thromboembolism; right heart failure; survival.
© The Author(s) 2014.
Source: PubMed