Insights into the management of gastric antral vascular ectasia (watermelon stomach)

Wen-Hung Hsu, Yao-Kuang Wang, Meng-Shu Hsieh, Fu-Chen Kuo, Meng-Chieh Wu, Hsiang-Yao Shih, I-Chen Wu, Fang-Jung Yu, Huang-Ming Hu, Yu-Chung Su, Deng-Chyang Wu, Wen-Hung Hsu, Yao-Kuang Wang, Meng-Shu Hsieh, Fu-Chen Kuo, Meng-Chieh Wu, Hsiang-Yao Shih, I-Chen Wu, Fang-Jung Yu, Huang-Ming Hu, Yu-Chung Su, Deng-Chyang Wu

Abstract

Gastric antral vascular ectasia (GAVE) is an uncommon but important cause of chronic gastrointestinal bleeding. It is often associated with systemic diseases such as autoimmune diseases, liver cirrhosis, chronic renal insufficiency and cardiovascular disease. The etiology of GAVE has not been fully explored and remains controversial. Diagnosis is mainly based on endoscopic presentation with flat or raised erythematous stripes radiating from the pylorus to the antrum and resembles a watermelon. Clinical presentation may range from iron-deficiency anemia secondary to occult blood loss, melena to hematemesis. In past decades, many therapeutic modalities including medical, endoscopic and surgical intervention have been introduced for GAVE treatment with variable efficacy. Herein, we review the efficacy and safety of these treatment options for GAVE.

Keywords: antrectomy; endoscopic hemostasis; gastric antral vascular ectasia; gastrointestinal bleeding.

Conflict of interest statement

Conflict of interest statement: The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Management of gastric antral vascular ectasia. Nd: YAG, neodymium-yttrium-aluminum garnet laser.
Figure 2.
Figure 2.
Argon plasma coagulation treatment of gastric antral vascular ectasia.

References

    1. Jabbari M, Cherry R, Lough JO, et al. Gastric antral vascular ectasia: the watermelon stomach. Gastroenterology 1984; 87: 1165–1170.
    1. Chawla SK, Ramani K, Lo Presti P. The honeycomb stomach: coalesced gastric angiodysplasia. Gastrointest Endosc 1990; 36: 516–518.
    1. Suit PF, Petras RE, Bauer TW, et al. Gastric antral vascular ectasia. A histologic and morphometric study of “the watermelon stomach”. Am J Surg Pathol 1987; 11: 750–757.
    1. Gilliam JH, III, Geisinger KR, Wu WC, et al. Endoscopic biopsy is diagnostic in gastric antral vascular ectasia. The “watermelon stomach”. Dig Dis Sci 1989; 34: 885–888.
    1. Gostout CJ, Viggiano TR, Ahlquist DA, et al. The clinical and endoscopic spectrum of the watermelon stomach. J Clin Gastroenterol 1992; 15: 256–263.
    1. Liberski SM, Mcgarrity TJ, Hartle RJ, et al. The watermelon stomach: long-term outcome in patients treated with Nd:YAG laser therapy. Gastrointest Endosc 1994; 40: 584–587.
    1. Dulai GS, Jensen DM, Kovacs TO, et al. Endoscopic treatment outcomes in watermelon stomach patients with and without portal hypertension. Endoscopy 2004; 36: 68–72.
    1. Sargeant IR, Loizou LA, Rampton D, et al. Laser ablation of upper gastrointestinal vascular ectasias: long term results. Gut 1993; 34: 470–475.
    1. Bourke MJ, Hope RL, Boyd P, et al. Endoscopic laser therapy for watermelon stomach. J Gastroenterol Hepatol 1996; 11: 832–834.
    1. Quintero E, Pique JM, Bombi JA, et al. Gastric mucosal vascular ectasias causing bleeding in cirrhosis. A distinct entity associated with hypergastrinemia and low serum levels of pepsinogen I. Gastroenterology 1987; 93: 1054–1061.
    1. Lorenzi AR, Johnson AH, Davies G, et al. Gastric antral vascular ectasia in systemic sclerosis: complete resolution with methylprednisolone and cyclophosphamide. Ann Rheum Dis 2001; 60: 796–798.
    1. Rawlinson WD, Barr GD, Lin BP. Antral vascular ectasia: the “Watermelon” stomach. Med J Aust 1986; 144: 709–711.
    1. Kruger R, Ryan ME, Dickson KB, et al. Diffuse vascular ectasia of the gastric antrum. Am J Gastroenterol 1987; 82: 421–426.
    1. Cales P, Voigt JJ, Payen JL, et al. Diffuse vascular ectasia of the antrum, duodenum, and jejunum in a patient with nodular regenerative hyperplasia. Lack of response to portosystemic shunt or gastrectomy. Gut 1993; 34: 558–561.
    1. Van Cutsem E, Rutgeerts P, Vantrappen G. Treatment of bleeding gastrointestinal vascular malformations with oestrogen-progesterone. Lancet 1990; 335: 953–955.
    1. Manning RJ. Estrogen/progesterone treatment of diffuse antral vascular ectasia. Am J Gastroenterol 1995; 90: 154–156.
    1. Tran A, Villeneuve JP, Bilodeau M, et al. Treatment of chronic bleeding from gastric antral vascular ectasia (GAVE) with estrogen-progesterone in cirrhotic patients: an open pilot study. Am J Gastroenterol 1999; 94: 2909–2911.
    1. Moss SF, Ghosh P, Thomas DM, et al. Gastric antral vascular ectasia: maintenance treatment with oestrogen-progesterone. Gut 1992; 33: 715–717.
    1. Nardone G, Rocco A, Balzano T, et al. The efficacy of octreotide therapy in chronic bleeding due to vascular abnormalities of the gastrointestinal tract. Aliment Pharmacol Ther 1999; 13: 1429–1436.
    1. Barbara G, De Giorgio R, Salvioli B, et al. Unsuccessful octreotide treatment of the watermelon stomach. J Clin Gastroenterol 1998; 26: 345–346.
    1. Park RH, Danesh BJ, Upadhyay R, et al. Gastric antral vascular ectasia (watermelon stomach): therapeutic options. Postgrad Med J 1990; 66: 720–723.
    1. Mccormick PA, Ooi H, Crosbie O. Tranexamic acid for severe bleeding gastric antral vascular ectasia in cirrhosis. Gut 1998; 42: 750–752.
    1. Khan S, Vaishnavi A. Pharmacotherapy for gastric antral vascular ectasia: dramatic response to tranexamic acid. Gastrointest Endosc 2009; 70: 191; author reply 191–192.
    1. Ge ZZ, Chen HM, Gao YJ, et al. Efficacy of thalidomide for refractory gastrointestinal bleeding from vascular malformation. Gastroenterology 2011; 141: 1629–1637.e1621–1624.
    1. Moser S, Tischer A, Karpi A, et al. Evidence that thalidomide is effective in recurrent bleeding from watermelon stomach associated with liver cirrhosis. Endoscopy 2014; 46(Suppl. 1 UCTN): E384.
    1. Dunne KA, Hill J, Dillon JF. Treatment of chronic transfusion-dependent gastric antral vascular ectasia (watermelon stomach) with thalidomide. Eur J Gastroenterol Hepatol 2006; 18: 455–456.
    1. Kantsevoy SV, Cruz-Correa MR, Vaughn CA, et al. Endoscopic cryotherapy for the treatment of bleeding mucosal vascular lesions of the GI tract: a pilot study. Gastrointest Endosc 2003; 57: 403–406.
    1. Cho S, Zanati S, Yong E, et al. Endoscopic cryotherapy for the management of gastric antral vascular ectasia. Gastrointest Endosc 2008; 68: 895–902.
    1. American Society for Gastrointestinal Endoscopy Technology. Mucosal ablation devices. Gastrointest Endosc 2008; 68: 1031–1042.
    1. Potamiano S, Carter CR, Anderson JR. Endoscopic laser treatment of diffuse gastric antral vascular ectasia. Gut 1994; 35: 461–463.
    1. Geller A, Gostout CJ, Balm RK. Development of hyperplastic polyps following laser therapy for watermelon stomach. Gastrointest Endosc 1996; 43: 54–56.
    1. Calamia KT, Scolapio JS, Viggiano TR. Endoscopic YAG laser treatment of watermelon stomach (gastric antral vascular ectasia) in patients with systemic sclerosis. Clin Exp Rheumatol 2000; 18: 605–608.
    1. Mathou NG, Lovat LB, Thorpe SM, et al. Nd:YAG laser induces long-term remission in transfusion-dependent patients with watermelon stomach. Lasers Med Sci 2004; 18: 213–218.
    1. Bernstein CN, Pettigrew N, Wang KK, et al. Multifocal gastric neoplasia after recurrent laser therapy for the watermelon stomach. Can J Gastroenterol 1997; 11: 403–406.
    1. Pavey DA, Craig PI. Endoscopic therapy for upper-Gi vascular ectasias. Gastrointest Endosc 2004; 59: 233–238.
    1. Rosenfeld G, Enns R. Argon photocoagulation in the treatment of gastric antral vascular ectasia and radiation proctitis. Can J Gastroenterol 2009; 23: 801–804.
    1. Roman S, Saurin JC, Dumortier J, et al. Tolerance and efficacy of argon plasma coagulation for controlling bleeding in patients with typical and atypical manifestations of watermelon stomach. Endoscopy 2003; 35: 1024–1028.
    1. Sebastian S, Mcloughlin R, Qasim A, et al. Endoscopic argon plasma coagulation for the treatment of gastric antral vascular ectasia (watermelon stomach): long-term results. Dig Liver Dis 2004; 36: 212–217.
    1. Kwan V, Bourke MJ, Williams SJ, et al. Argon plasma coagulation in the management of symptomatic gastrointestinal vascular lesions: experience in 100 consecutive patients with long-term follow-up. Am J Gastroenterol 2006; 101: 58–63.
    1. Herrera S, Bordas JM, Llach J, et al. The beneficial effects of argon plasma coagulation in the management of different types of gastric vascular ectasia lesions in patients admitted for GI hemorrhage. Gastrointest Endosc 2008; 68: 440–446.
    1. Naga M, Esmat S, Naguib M, et al. Long-term effect of argon plasma coagulation (APC) in the treatment of gastric antral vascular ectasia (GAVE). Arab J Gastroenterol 2011; 12: 40–43.
    1. Chaves DM, Sakai P, Oliveira CV, et al. Watermelon stomach: clinical aspects and treatment with argon plasma coagulation. Arq Gastroenterol 2006; 43: 191–195.
    1. Fuccio L, Zagari RM, Serrani M, et al. Endoscopic argon plasma coagulation for the treatment of gastric antral vascular ectasia-related bleeding in patients with liver cirrhosis. Digestion 2009; 79: 143–150.
    1. Boltin D, Gingold-Belfer R, Lichtenstein L, et al. Long-term treatment outcome of patients with gastric vascular ectasia treated with argon plasma coagulation. Eur J Gastroenterol Hepatol 2014; 26: 588–593.
    1. Chiu YC, Lu LS, Wu KL, et al. Comparison of argon plasma coagulation in management of upper gastrointestinal angiodysplasia and gastric antral vascular ectasia hemorrhage. BMC Gastroenterol 2012; 12: 67.
    1. Patwardhan VR, Cardenas A. Review article: the management of portal hypertensive gastropathy and gastric antral vascular ectasia in cirrhosis. Aliment Pharmacol Ther 2014; 40: 354–362.
    1. Baudet JS, Salata H, Soler M, et al. Hyperplastic gastric polyps after argon plasma coagulation treatment of gastric antral vascular ectasia (GAVE). Endoscopy 2007; 39(Suppl. 1): E320.
    1. Farooq FT, Wong RC, Yang P, et al. Gastric outlet obstruction as a complication of argon plasma coagulation for watermelon stomach. Gastrointest Endosc 2007; 65: 1090–1092.
    1. Matsui S, Kamisako T, Kudo M, et al. Endoscopic band ligation for control of nonvariceal upper GI hemorrhage: comparison with bipolar electrocoagulation. Gastrointest Endosc 2002; 55: 214–218.
    1. Junquera F, Brullet E, Campo R, et al. Usefulness of endoscopic band ligation for bleeding small bowel vascular lesions. Gastrointest Endosc 2003; 58: 274–279.
    1. Sinha SK, Udawat HP, Varma S, et al. Watermelon stomach treated with endoscopic band ligation. Gastrointest Endosc 2006; 64: 1028–1031.
    1. Wells CD, Harrison ME, Gurudu SR, et al. Treatment of gastric antral vascular ectasia (watermelon stomach) with endoscopic band ligation. Gastrointest Endosc 2008; 68: 231–236.
    1. Keohane J, Berro W, Harewood GC, et al. Band ligation of gastric antral vascular ectasia is a safe and effective endoscopic treatment. Dig Endosc 2013; 25: 392–396.
    1. Sato T, Yamazaki K, Akaike J. Endoscopic band ligation versus argon plasma coagulation for gastric antral vascular ectasia associated with liver diseases. Dig Endosc 2012; 24: 237–242.
    1. Zepeda-Gomez S, Sultanian R, Teshima C, et al. Gastric antral vascular ectasia: a prospective study of treatment with endoscopic band ligation. Endoscopy 2015; 47: 538–540.
    1. Peter S, Wilcox CM. Radiofrequency ablation therapy: the grave for GAVE (gastric antral vascular ectasia)? Endosc Int Open 2015; 3: E128–E129.
    1. Gross SA, Al-Haddad M, Gill KR, et al. Endoscopic mucosal ablation for the treatment of gastric antral vascular ectasia with the HALO90 system: a pilot study. Gastrointest Endosc 2008; 67: 324–327.
    1. Mcgorisk T, Krishnan K, Keefer L, et al. Radiofrequency ablation for refractory gastric antral vascular ectasia (with video). Gastrointest Endosc 2013; 78: 584–588.
    1. Dray X, Repici A, Gonzalez P, et al. Radiofrequency ablation for the treatment of gastric antral vascular ectasia. Endoscopy 2014; 46: 963–969.
    1. Markos P, Bilic B, Ivekovic H, et al. Radiofrequency ablation for gastric antral vascular ectasia and radiation proctitis. Indian J Gastroenterol 2017; 36: 145–148.
    1. Becq A, Camus M, Rahmi G, et al. Emerging indications of endoscopic radiofrequency ablation. United Eur Gastroenterol J 2015; 3: 313–324.
    1. Novitsky YW, Kercher KW, Czerniach DR, et al. Watermelon stomach: pathophysiology, diagnosis, and management. J Gastrointest Surg 2003; 7: 652–661.
    1. Sherman V, Klassen DR, Feldman LS, et al. Laparoscopic antrectomy: a novel approach to treating watermelon stomach. J Am Coll Surg 2003; 197: 864–867.
    1. Spahr L, Villeneuve J, Dufresne M, et al. Gastric antral vascular ectasia in cirrhotic patients: absence of relation with portal hypertension. Gut 1999; 44: 739–742.
    1. Makharia G, Behra A, Kaman L, et al. Watermelon stomach: a rare cause of upper gastrointestinal bleeding. Indian J Gastroenterol 1999; 18: 86–87.

Source: PubMed

3
Iratkozz fel