Maternal age, multiple birth, and extremely low birth weight infants
Betty R Vohr, Jon E Tyson, Linda L Wright, Rebecca L Perritt, Lei Li, W Kenneth Poole, NICHD Neonatal Research Network, Alan Jobe, William Oh, Abbot R Laptook, Rachel A Vogt, Angelita Hensman, Lucy Noel, Barbara Alksninis, Shabnam Lainwala, Teresa M Leach, Martha R Leonard, Kalida Mehta, James Moore, Bonnie Stephens, Victoria E Watson, Avroy A Fanaroff, Michele C Walsh, Deanne Wilson-Costello, Nancy S Newman, Bonnie S Siner, Harriet G Friedman, Eileen Stork, Ronald N Goldberg, C Michael Cotton, Ricki F Goldstein, Kathy J Auten, Melody B Lohmeyer, Kathryn Gustafson, Barbara J Stoll, Lucky Jain, Ira Adams-Chapman, Neal P Simon, Ellen C Hale, Maureen Mulligan LaRossa, Linda Black, Sheena Carter, Elisabeth Dinkins, Judson Miller, Irma Seabrook, Gloria Smikle, Michelle Tidwell, Rosemary D Higgins, Elizabeth M McClure, Joel Verter, Tonya Powers, Ann R Stark, Kimberly Gronsman Lee, Kerri Fournier, Stacy Dow, Colleen Driscoll, James A Lemons, Brenda B Poindexter, Anna M Dusick, Greg Sokol, Marilyn Bull, Darlene Kardatzke, Carolyn Lytle, Diana D Appel, Dianne Herron, Lucy Miller, Leslie Richard, Leslie Dawn Wilson, Lon G Bohnke, Greg Eaken, Ann Cook, Heike Minnich, Abhik Das, Betty Hastings, Carolyn Petrie Huitema, Elizabeth Mc-Clure, Kristin Zaterka-Baxter, Scott E Schaefer, Jeanette O'Donnell Auman, David K Stevenson, Krisa P Van Meurs, Susan R Hintz, M Bethany Ball, Marian M Adams, Joan M Baran, Lori E Bond, Ginger Brudos, Maria Elena DeAnda, Anne M DeBattista, Barry E Fleisher, Monica Hajdena-Dawson, Jean Kohn, Carol G Kuelper, Julie C Lee, Melinda S Proud, Renee P Pyle, Dharshi Sivakumar, Nicholas St John, Waldemar A Carlo, Namasivayam Ambalavanan, Myriam Peralta-Carcelen, Monica V Collins, Shirley S Cosby, Vivien Phillips, Kirstin J Bailey, Fred J Biasini, Stephanie A Chopko, Julie Preskitt, MaryBeth Moses, Kathleen Nelson, Richard V Rector, Sally Whitley, Neil N Finer, Maynard R Rasmussen, Yvonne E Vaucher, Kathy Arnell, Clarence Demetrio, Martha G Fuller, Chris Henderson, Wade Rich, Rene Barbieri-Welge, Ayala Ben-Tall, Elaine Ito, Meghan Lukasik, Deborah Pontillo, Donna Posin, Cheryl Runyan, James Wilkes, Edward F Donovan, Jean Steichen, Kurt Schibler, Kathleen Bridges, John Fridriksson, Barb Alexander, Cathy Grisby, Teresa L Gratton, Marcia Mersmann, Holly Mincey, Jody Shively, Shahnaz Duara, Charles R Bauer, Sylvia Hiriart-Fajardo, Ruth Everett-Thomas, Mary Allison, Carmel Azemar, Maria Calejo, Alexis N Diaz, Silvia M Frade Eguaras, Yamiley C Gideon, Wendy Griffin, Rafael Guzman, Kasey Hamlin-Smith, Elizabeth Jacque, Lisa Jean-Gilles, Ann Londono, Elaine O Mathews, Alexandra Stroerger, Lu-Ann Papile, Conra Backstrom Lacy, Jean Lowe, Ginny Laadt, Debra V Long, Dale L Phelps, Ronnie Guillet, Gary J Myers, Carl T D'Angio, Linda J Reubens, Diane Hust, Rosemary L Jensen, Erica Burnell, Julie Babish Johnson, Cassandra A Horihan, Emily Kushner, Joan Merzbach, Gina Rowan, Kelley Yost, Lauren Zwetsch, Kristina Mossgraber, Sheldon B Korones, Henrietta S Bada, Kim Yolton, Tina Hudson, Abbot R Laptook, Charles R Rosenfeld, Walid A Salhab, R Sue Broyles, Roy J Heyne, Ricardo D Uauy, Susie Madison, Jackie F Hickman, Gaynelle Hensley, Nancy A Miller, Janet S Morgan, Sally Adams, Cathy Boatman, Cristin Dooley, Alicia Guzman, Elizabeth Heyne, Cristine Lupino, Linda Madden, Kathleen A Kennedy, Brenda H Morris, Pamela J Bradt, Patricia W Evans, Terri Major-Kincade, Laura L Whitely, Esther G Akpa, Magda Cedillo, Patty A Cluff, Anna E Lis, Georgia E McDavid, Claudia Y Franco, Nora I Alaniz, Susan Dieterich, Stacey Reddoch, Patti L Tate, T Michael O'Shea, Robert G Dillard, Lisa K Washburn, Nancy J Peters, Barbara G Jackson, Debbie Allred, Korinne Chiu, Don Goldstein, Raquel Halfond, Cherie Heller, Gail Hounshell, Melissa Morris, Carol Peterson, Ellen Waldrep, Seetha Shankaran, Yvette Johnson, Athina Pappas, Rebecca Bara, Geraldine Muran, Deborah Kennedy, Laura Goldston, Richard A Ehrenkranz, Ian Gross, Michael D Kaplan, Linda Mayes, Patricia Gettner, Monica Konstantino, Elaine Romano, Pat Cervone, Nancy Close, Betty R Vohr, Jon E Tyson, Linda L Wright, Rebecca L Perritt, Lei Li, W Kenneth Poole, NICHD Neonatal Research Network, Alan Jobe, William Oh, Abbot R Laptook, Rachel A Vogt, Angelita Hensman, Lucy Noel, Barbara Alksninis, Shabnam Lainwala, Teresa M Leach, Martha R Leonard, Kalida Mehta, James Moore, Bonnie Stephens, Victoria E Watson, Avroy A Fanaroff, Michele C Walsh, Deanne Wilson-Costello, Nancy S Newman, Bonnie S Siner, Harriet G Friedman, Eileen Stork, Ronald N Goldberg, C Michael Cotton, Ricki F Goldstein, Kathy J Auten, Melody B Lohmeyer, Kathryn Gustafson, Barbara J Stoll, Lucky Jain, Ira Adams-Chapman, Neal P Simon, Ellen C Hale, Maureen Mulligan LaRossa, Linda Black, Sheena Carter, Elisabeth Dinkins, Judson Miller, Irma Seabrook, Gloria Smikle, Michelle Tidwell, Rosemary D Higgins, Elizabeth M McClure, Joel Verter, Tonya Powers, Ann R Stark, Kimberly Gronsman Lee, Kerri Fournier, Stacy Dow, Colleen Driscoll, James A Lemons, Brenda B Poindexter, Anna M Dusick, Greg Sokol, Marilyn Bull, Darlene Kardatzke, Carolyn Lytle, Diana D Appel, Dianne Herron, Lucy Miller, Leslie Richard, Leslie Dawn Wilson, Lon G Bohnke, Greg Eaken, Ann Cook, Heike Minnich, Abhik Das, Betty Hastings, Carolyn Petrie Huitema, Elizabeth Mc-Clure, Kristin Zaterka-Baxter, Scott E Schaefer, Jeanette O'Donnell Auman, David K Stevenson, Krisa P Van Meurs, Susan R Hintz, M Bethany Ball, Marian M Adams, Joan M Baran, Lori E Bond, Ginger Brudos, Maria Elena DeAnda, Anne M DeBattista, Barry E Fleisher, Monica Hajdena-Dawson, Jean Kohn, Carol G Kuelper, Julie C Lee, Melinda S Proud, Renee P Pyle, Dharshi Sivakumar, Nicholas St John, Waldemar A Carlo, Namasivayam Ambalavanan, Myriam Peralta-Carcelen, Monica V Collins, Shirley S Cosby, Vivien Phillips, Kirstin J Bailey, Fred J Biasini, Stephanie A Chopko, Julie Preskitt, MaryBeth Moses, Kathleen Nelson, Richard V Rector, Sally Whitley, Neil N Finer, Maynard R Rasmussen, Yvonne E Vaucher, Kathy Arnell, Clarence Demetrio, Martha G Fuller, Chris Henderson, Wade Rich, Rene Barbieri-Welge, Ayala Ben-Tall, Elaine Ito, Meghan Lukasik, Deborah Pontillo, Donna Posin, Cheryl Runyan, James Wilkes, Edward F Donovan, Jean Steichen, Kurt Schibler, Kathleen Bridges, John Fridriksson, Barb Alexander, Cathy Grisby, Teresa L Gratton, Marcia Mersmann, Holly Mincey, Jody Shively, Shahnaz Duara, Charles R Bauer, Sylvia Hiriart-Fajardo, Ruth Everett-Thomas, Mary Allison, Carmel Azemar, Maria Calejo, Alexis N Diaz, Silvia M Frade Eguaras, Yamiley C Gideon, Wendy Griffin, Rafael Guzman, Kasey Hamlin-Smith, Elizabeth Jacque, Lisa Jean-Gilles, Ann Londono, Elaine O Mathews, Alexandra Stroerger, Lu-Ann Papile, Conra Backstrom Lacy, Jean Lowe, Ginny Laadt, Debra V Long, Dale L Phelps, Ronnie Guillet, Gary J Myers, Carl T D'Angio, Linda J Reubens, Diane Hust, Rosemary L Jensen, Erica Burnell, Julie Babish Johnson, Cassandra A Horihan, Emily Kushner, Joan Merzbach, Gina Rowan, Kelley Yost, Lauren Zwetsch, Kristina Mossgraber, Sheldon B Korones, Henrietta S Bada, Kim Yolton, Tina Hudson, Abbot R Laptook, Charles R Rosenfeld, Walid A Salhab, R Sue Broyles, Roy J Heyne, Ricardo D Uauy, Susie Madison, Jackie F Hickman, Gaynelle Hensley, Nancy A Miller, Janet S Morgan, Sally Adams, Cathy Boatman, Cristin Dooley, Alicia Guzman, Elizabeth Heyne, Cristine Lupino, Linda Madden, Kathleen A Kennedy, Brenda H Morris, Pamela J Bradt, Patricia W Evans, Terri Major-Kincade, Laura L Whitely, Esther G Akpa, Magda Cedillo, Patty A Cluff, Anna E Lis, Georgia E McDavid, Claudia Y Franco, Nora I Alaniz, Susan Dieterich, Stacey Reddoch, Patti L Tate, T Michael O'Shea, Robert G Dillard, Lisa K Washburn, Nancy J Peters, Barbara G Jackson, Debbie Allred, Korinne Chiu, Don Goldstein, Raquel Halfond, Cherie Heller, Gail Hounshell, Melissa Morris, Carol Peterson, Ellen Waldrep, Seetha Shankaran, Yvette Johnson, Athina Pappas, Rebecca Bara, Geraldine Muran, Deborah Kennedy, Laura Goldston, Richard A Ehrenkranz, Ian Gross, Michael D Kaplan, Linda Mayes, Patricia Gettner, Monica Konstantino, Elaine Romano, Pat Cervone, Nancy Close
Abstract
Objectives: To compare the rates of adverse neurodevelopmental outcome or death at 18 to 22 months among extremely low birth weight (ELBW) infants born to mothers >or=4 0 years to the corresponding rates among infants of younger mothers.
Study design: Prospective evaluation of ELBW infants to quantify the relative risks of maternal age and multiple birth for death or adverse neurodevelopmental outcome.
Results: The sample consisted of 14 671 live ELBW births divided into maternal age groups: <20, 20 to 29, 30 to 39, and >or= 40 years. Of infants born to mothers >or= 40 years, 20% were multiples. Mothers >or= 40 years had high rates of obstetric interventions and medical morbidities compared with mothers <40 years. ELBW live births of mothers >or= 40 years were 22% more likely to survive and had a 13% decreased risk of neurodevelopmental impairment or death compared with mothers <20. Multiple birth, however, was associated with a 10% greater risk of neurodevelopmental impairment or death.
Conclusion: Although mothers >or= 40 years had high pregnancy-related morbidities, we found no overall increased risk of the composite outcome of death or NDI. Multiple birth, however, was a predictor of all adverse outcomes examined, regardless of maternal age.
Source: PubMed