Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort
Betty R Vohr, Roy Heyne, Carla M Bann, Abhik Das, Rosemary D Higgins, Susan R Hintz, Eunice Kennedy Shriver National Institute of Child Health, and Development Neonatal Research Network, Alan H Jobe, Michael S Caplan, Richard A Polin, Abbot R Laptook, Angelita M Hensman, Elisabeth C McGowan, Elisa Vieira, Emilee Little, Katharine Johnson, Barbara Alksninis, Mary Lenore Keszler, Andrea M Knoll, Theresa M Leach, Victoria E Watson, Michele C Walsh, Avroy A Fanaroff, Deanne E Wilson-Costello, Allison Payne, Nancy S Newman, H Gerry Taylor, Bonnie S Siner, Arlene Zadell, Julie DiFiore, Monika Bhola, Harriet G Friedman, Gulgun Yalcinkaya, Dorothy Bulas, Ronald N Goldberg, C Michael Cotten, Ricki F Goldstein, Kathryn E Gustafson, Patricia Ashley, Kathy J Auten, Kimberley A Fisher, Katherine A Foy, Sharon F Freedman, Melody B Lohmeyer, William F Malcolm, David K Wallace, David P Carlton, Barbara J Stoll, Ira Adams-Chapman, Susie Buchter, Anthony J Piazza, Carter, Sobha Fritz, Ellen C Hale, Amy K Hutchinson, Maureen Mulligan LaRossa, Yvonne Loggins, Diane Bottcher, Stephanie Wilson Archer, Brenda B Poindexter, Gregory M Sokol, Heidi M Harmon, Lu-Ann Papile, Abbey C Hines, Leslie D Wilson, Dianne E Herron, Lucy Smiley, Kathleen A Kennedy, Jon E Tyson, Andrea Freeman Duncan, Allison G Dempsey, Janice John, Patrick M Jones, M Layne Lillie, Saba Siddiki, Daniel K Sperry, Mary Anne Berberich, Carol J Blaisdell, Dorothy B Gail, James P Kiley, Dennis Wallace, Marie G Gantz, Jamie E Newman, Jeanette O'Donnell Auman, Jane A Hammond, W Kenneth Poole, Krisa P Van Meurs, David K Stevenson, Maria Elena DeAnda, M Bethany Ball, Gabrielle T Goodlin, Ivan D Frantz 3rd, John M Fiascone, Elisabeth C McGowan, Anne Furey, Brenda L MacKinnon, Ellen Nylen, Ana Brussa, Cecelia Sibley, Waldemar A Carlo, Namasivayam Ambalavanan, Myriam Peralta-Carcelen, Monica V Collins, Shirley S Cosby, Vivien A Phillips, Kirstin J Bailey, Fred J Biasini, Maria Hopkins, Kristen C Johnston, Kathleen G Nelson, Cryshelle S Patterson, Richard V Rector, Leslie Rodriguez, Amanda Soong, Sally Whitley, Sheree York, Kristy Guest, Leigh Ann Smith, Neil N Finer, Donna Garey, Maynard R Rasmussen, Paul R Wozniak, Yvonne E Vaucher, Martha G Fuller, Natacha Akshoomoff, Wade Rich, Kathy Arnell, Renee Bridge, Edward F Bell, Tarah T Colaizy, John A Widness, Jonathan M Klein, Karen J Johnson, Michael J Acarregui, Diane L Eastman, Tammy L V Wilgenbusch, Kristi L Watterberg, Robin K Ohls, Janell Fuller, Jean Lowe, Julie Rohr, Conra Backstrom Lacy, Rebecca Montman, Sandra Brown, Pablo J Sánchez, Charles R Rosenfeld, Walid A Salhab, Luc Brion, Sally S Adams, James Allen, Laura Grau, Alicia Guzman, Gaynelle Hensley, Elizabeth T Heyne, Jackie F Hickman, Melissa H Leps, Linda A Madden, Melissa Martin, Nancy A Miller, Janet S Morgan, Araceli Solis, Lizette E Lee, Catherine Twell Boatman, Diana M Vasil, Bradley A Yoder, Roger G Faix, Sarah Winter, Shawna Baker, Karen A Osborne, Carrie A Rau, Sean Cunningham, Ariel Ford, Seetha Shankaran, Athina Pappas, Beena G Sood, Rebecca Bara, Thomas L Slovis, Elizabeth Billian, Laura A Goldston, Mary Johnson, Betty R Vohr, Roy Heyne, Carla M Bann, Abhik Das, Rosemary D Higgins, Susan R Hintz, Eunice Kennedy Shriver National Institute of Child Health, and Development Neonatal Research Network, Alan H Jobe, Michael S Caplan, Richard A Polin, Abbot R Laptook, Angelita M Hensman, Elisabeth C McGowan, Elisa Vieira, Emilee Little, Katharine Johnson, Barbara Alksninis, Mary Lenore Keszler, Andrea M Knoll, Theresa M Leach, Victoria E Watson, Michele C Walsh, Avroy A Fanaroff, Deanne E Wilson-Costello, Allison Payne, Nancy S Newman, H Gerry Taylor, Bonnie S Siner, Arlene Zadell, Julie DiFiore, Monika Bhola, Harriet G Friedman, Gulgun Yalcinkaya, Dorothy Bulas, Ronald N Goldberg, C Michael Cotten, Ricki F Goldstein, Kathryn E Gustafson, Patricia Ashley, Kathy J Auten, Kimberley A Fisher, Katherine A Foy, Sharon F Freedman, Melody B Lohmeyer, William F Malcolm, David K Wallace, David P Carlton, Barbara J Stoll, Ira Adams-Chapman, Susie Buchter, Anthony J Piazza, Carter, Sobha Fritz, Ellen C Hale, Amy K Hutchinson, Maureen Mulligan LaRossa, Yvonne Loggins, Diane Bottcher, Stephanie Wilson Archer, Brenda B Poindexter, Gregory M Sokol, Heidi M Harmon, Lu-Ann Papile, Abbey C Hines, Leslie D Wilson, Dianne E Herron, Lucy Smiley, Kathleen A Kennedy, Jon E Tyson, Andrea Freeman Duncan, Allison G Dempsey, Janice John, Patrick M Jones, M Layne Lillie, Saba Siddiki, Daniel K Sperry, Mary Anne Berberich, Carol J Blaisdell, Dorothy B Gail, James P Kiley, Dennis Wallace, Marie G Gantz, Jamie E Newman, Jeanette O'Donnell Auman, Jane A Hammond, W Kenneth Poole, Krisa P Van Meurs, David K Stevenson, Maria Elena DeAnda, M Bethany Ball, Gabrielle T Goodlin, Ivan D Frantz 3rd, John M Fiascone, Elisabeth C McGowan, Anne Furey, Brenda L MacKinnon, Ellen Nylen, Ana Brussa, Cecelia Sibley, Waldemar A Carlo, Namasivayam Ambalavanan, Myriam Peralta-Carcelen, Monica V Collins, Shirley S Cosby, Vivien A Phillips, Kirstin J Bailey, Fred J Biasini, Maria Hopkins, Kristen C Johnston, Kathleen G Nelson, Cryshelle S Patterson, Richard V Rector, Leslie Rodriguez, Amanda Soong, Sally Whitley, Sheree York, Kristy Guest, Leigh Ann Smith, Neil N Finer, Donna Garey, Maynard R Rasmussen, Paul R Wozniak, Yvonne E Vaucher, Martha G Fuller, Natacha Akshoomoff, Wade Rich, Kathy Arnell, Renee Bridge, Edward F Bell, Tarah T Colaizy, John A Widness, Jonathan M Klein, Karen J Johnson, Michael J Acarregui, Diane L Eastman, Tammy L V Wilgenbusch, Kristi L Watterberg, Robin K Ohls, Janell Fuller, Jean Lowe, Julie Rohr, Conra Backstrom Lacy, Rebecca Montman, Sandra Brown, Pablo J Sánchez, Charles R Rosenfeld, Walid A Salhab, Luc Brion, Sally S Adams, James Allen, Laura Grau, Alicia Guzman, Gaynelle Hensley, Elizabeth T Heyne, Jackie F Hickman, Melissa H Leps, Linda A Madden, Melissa Martin, Nancy A Miller, Janet S Morgan, Araceli Solis, Lizette E Lee, Catherine Twell Boatman, Diana M Vasil, Bradley A Yoder, Roger G Faix, Sarah Winter, Shawna Baker, Karen A Osborne, Carrie A Rau, Sean Cunningham, Ariel Ford, Seetha Shankaran, Athina Pappas, Beena G Sood, Rebecca Bara, Thomas L Slovis, Elizabeth Billian, Laura A Goldston, Mary Johnson
Abstract
Objective: To identify rates of overweight (body mass index [BMI] ≥85th percentile) and obesity (BMI ≥95th percentile) at 6-7 years of age and associated risk factors among extremely preterm infants born at <28 weeks of gestation.
Study design: Anthropometrics, blood pressure, and active and sedentary activity levels were prospectively assessed. Three groups were compared, those with a BMI ≥85th percentile (overweight or obese for age, height, and sex) and ≥95th percentile (obese) vs <85th percentile. Multiple regression analyses estimated the relative risks of BMI ≥85th percentile and ≥95th percentile associated with perinatal and early childhood factors.
Results: Of 388 children, 22% had a BMI of ≥85th percentile and 10% were obese. Children with obesity and overweight compared with normal weight children had higher body fat (subscapular skinfold and triceps skinfold >85th percentile), central fat (waist circumference >90th percentile), spent more time in sedentary activity (20.5 vs 18.2 vs 16.7 hours/week), and had either systolic and/or diastolic hypertension (24% vs 26% vs 14%), respectively. Postdischarge weight gain velocities from 36 weeks postmenstrual age to 18 months, and 18 months to 6-7 years were independently associated with a BMI of ≥85th percentile, whereas weight gain velocity from 18 months to 6-7 years was associated with obesity.
Conclusions: One in 5 former extremely preterm infants is overweight or obese and has central obesity at early school age. Postdischarge weight gain velocities were associated with overweight and obesity. These findings suggest the obesity epidemic is spreading to the most extremely preterm infants.
Trial registration: ClinicalTrials.gov: NCT00063063 and NCT0000.
Trial registration: ClinicalTrials.gov NCT00063063 NCT00000000.
Keywords: hypertension; obese; overweight; preterm; school age; sedentary activity.
Conflict of interest statement
The authors declare no conflicts of interest.
Copyright © 2018 Elsevier Inc. All rights reserved.
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Source: PubMed