Comparative evaluation of calcium silicate-based dentin substitute (Biodentine®) and calcium hydroxide (pulpdent) in the formation of reactive dentin bridge in regenerative pulpotomy of vital primary teeth: Triple blind, randomized clinical trial

Navneet Grewal, Rubica Salhan, Nirapjeet Kaur, Hemal Bipin Patel, Navneet Grewal, Rubica Salhan, Nirapjeet Kaur, Hemal Bipin Patel

Abstract

Background: Considering the biological concerns of calcium hydroxide (CH) as a pulpotomy agent, an alternative silicate based dentin substitute i.e. Biodentine (Ca3SiO5) was evaluated clinically and radiographically.

Aims: To evaluate the effectiveness of dentin substitute (Biodentine) in regenerative pulpotomy of vital primary teeth that would giv a biological base to its use in forming reactive dentin bridge and overcoming the drawbacks of calcium hydroxide.

Material and methods: Randomised clinical trial on 40 bilateral carious primary molars in 20 participant children (aged 5-10 years) was carried out by same operator using Ca3SiO5(group-1) and CH (group-2) as vital pulpotomy agents. Blinded clinical and radiographic outcomes were observed at 3, 6 and 12 months interval.

Results: Clinical outcomes of both protocols were analysed using Pearson's chi-square test applied at P < 0.05. Descriptive statistics were expressed as mean increase in dentin bridge formation in mms from two reference points in standardized radiographs using paired 't'- test at baseline and 12 months and found to be statistically significant (P < 0.05) in group-1 when compared with group-2.

Conclusion: Group-1 revealed statistically favourable regenerative potential along with clinical success compared to group 2 thereby sharing both indications and mode of action with CH, but without its drawbacks of physical and clinical properties.

Keywords: Ca3 Sio5 - based dentin substitute; calcium hydroxide; dentin bridge; primary molars; regenerative pulpotomy.

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram showing study sample selection to final analysis of the sample
Figure 2
Figure 2
Reference points for measurements: Point-A (base of the material) to Point-B (furcation area)
Figure 3
Figure 3
Postoperative measurements. Baseline (a). Six months follow-up (b). Twelve-month follow-up (c) showing increase in dentin thickness

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Source: PubMed

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