Prevention and Treatment of White Spot Lesions in Orthodontic Patients

Maryam Khoroushi, Marzie Kachuie, Maryam Khoroushi, Marzie Kachuie

Abstract

Decalcification of enamel, appearing as white spot lesions (WSLs), around fixed orthodontic appliances is a major challenge during and after fixed orthodontic treatment by considering the fact that the goal of orthodontic treatment is to enhance facial and dental esthetic appearance. Banded or bonded teeth exhibit a significantly higher rate of WSLs compared to the controls with no braces as fixed appliances and the bonding materials promote retention of biofilms. These lesions are managed in the first step by establishing good oral hygiene habits and prophylaxis with topical fluorides, including high-fluoride toothpastes, fluoride mouthwashes, gels, varnishes, fluoride-containing bonding materials, and elastic ligatures. Recently, other materials and methods have been recommended, including the application of casein phosphopeptides-amorphous calcium phosphate, antiseptics, probiotics, polyols, sealants, laser, tooth bleaching agents, resin infiltration, and microabrasion. This article reviews the currently used methods to manage enamel demineralization during and after orthodontic treatment and the risk factors and preventive measures based on the latest evidence.

Keywords: Demineralization; oral hygiene; orthodontic treatment; remineralization; white spot.

Conflict of interest statement

There are no conflicts of interest.

References

    1. Kleter GA. Discoloration of dental carious lesions (a review) Arch Oral Biol. 1998;43:629–32.
    1. Zabokova-Bilbilova E, Popovska L, Kapusevska B, Stefanovska E. White spot lesions: Prevention and management during the orthodontic treatment. Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2014;35:161–8.
    1. Chapman JA, Roberts WE, Eckert GJ, Kula KS, González-Cabezas C. Risk factors for incidence and severity of white spot lesions during treatment with fixed orthodontic appliances. Am J Orthod Dentofacial Orthop. 2010;138:188–94.
    1. Bishara SE, Ostby AW. White spot lesions: Formation, prevention, and treatment. Semin Orthod. 2008;14:174–82.
    1. Heymann GC, Grauer D. A contemporary review of white spot lesions in orthodontics. J Esthet Restor Dent. 2013;25:85–95.
    1. Julien KC, Buschang PH, Campbell PM. Prevalence of white spot lesion formation during orthodontic treatment. Angle Orthod. 2013;83:641–7.
    1. Sangamesh B, Kallury A. Iatrogenic effects of orthodontic treatment – Review on white spot lesions. Int J Sci Eng Res. 2011;2:2–16.
    1. Pretty IA. Caries detection and diagnosis: Novel technologies. J Dent. 2006;34:727–39.
    1. Sundararaj D, Venkatachalapathy S, Tandon A, Pereira A. Critical evaluation of incidence and prevalence of white spot lesions during fixed orthodontic appliance treatment: A meta-analysis. J Int Soc Prev Community Dent. 2015;5:433–9.
    1. Khalaf K. Factors affecting the formation, severity and location of white spot lesions during orthodontic treatment with fixed appliances. J Oral Maxillofac Res. 2014;5:e4.
    1. Richter AE, Arruda AO, Peters MC, Sohn W. Incidence of caries lesions among patients treated with comprehensive orthodontics. Am J Orthod Dentofacial Orthop. 2011;139:657–64.
    1. Lundström F, Krasse B. Streptococcus mutans and lactobacilli frequency in orthodontic patients; the effect of chlorhexidine treatments. Eur J Orthod. 1987;9:109–16.
    1. Mattousch TJ, van der Veen MH, Zentner A. Caries lesions after orthodontic treatment followed by quantitative light-induced fluorescence: A 2-year follow-up. Eur J Orthod. 2007;29:294–8.
    1. Mizrahi E. Enamel demineralization following orthodontic treatment. Am J Orthod. 1982;82:62–7.
    1. Yagci A, Korkmaz YN, Buyuk SK, Yagci F, Atilla AO. White spot lesion formation after treatment with full-coverage rapid maxillary expanders. Am J Orthod Dentofacial Orthop. 2016;149:331–8.
    1. Tufekci E, Dixon JS, Gunsolley JC, Lindauer SJ. Prevalence of white spot lesions during orthodontic treatment with fixed appliances. Angle Orthod. 2011;81:206–10.
    1. Morrier JJ. White spot lesions and orthodontic treatment. Prevention and treatment. Orthod Fr. 2014;85:235–44.
    1. Sudjalim TR, Woods MG, Manton DJ. Prevention of white spot lesions in orthodontic practice: A contemporary review. Aust Dent J. 2006;51:284–9.
    1. Harvey WJ, Powell KR. Care of dental enamel for the orthodontic patient. Aust Orthod J. 1981;7:70–6.
    1. Øgaard B. Orthodontic Materials Scientific and Clinical Aspects. Stuttgart: Thieme; 2001. Oral microbiological changes, long-term enamel alterations due to decalcification, and caries prophylactic aspects; pp. 123–42.
    1. Kim S, Katchooi M, Bayiri B, Sarikaya M, Korpak AM, Huang GJ. Predicting improvement of postorthodontic white spot lesions. Am J Orthod Dentofacial Orthop. 2016;149:625–33.
    1. Davidson CL, Bekke-Hoekstra IS. The resistance of superficially sealed enamel to wear and carious attack in vitro. J Oral Rehabil. 1980;7:299–305.
    1. Marinho VC. Cochrane reviews of randomized trials of fluoride therapies for preventing dental caries. Eur Arch Paediatr Dent. 2009;10:183–91.
    1. Walsh T, Worthington HV, Glenny AM, Appelbe P, Marinho VC, Shi X. Fluoride toothpastes of different concentrations for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2010;1:CD007868.
    1. Al-Mulla A, Karlsson L, Kharsa S, Kjellberg H, Birkhed D. Combination of high-fluoride toothpaste and no post-brushing water rinsing on enamel demineralization using an in-situ caries model with orthodontic bands. Acta Odontol Scand. 2010;68:323–8.
    1. Bergstrand F, Twetman S. A review on prevention and treatment of post-orthodontic white spot lesions – Evidence-based methods and emerging technologies. Open Dent J. 2011;5:158–62.
    1. Feng CH, Chu XY. Efficacy of one year treatment of icon infiltration resin on post-orthodontic white spots. Beijing Da Xue Xue Bao. 2013;45:40–3.
    1. Bahoum A, Bahije L, Zaoui F. Enamel demineralization in orthodontics. Systematic use of fluoride in prevention and treatment. Schweiz Monatsschr Zahnmed. 2012;122:937–47.
    1. Benson PE, Parkin N, Dyer F, Millett DT, Furness S, Germain P. Fluorides for the prevention of early tooth decay (demineralised white lesions) during fixed brace treatment. Cochrane Database Syst Rev. 2013;12:CD003809.
    1. Benson PE, Parkin N, Millett DT, Dyer FE, Vine S, Shah A. Fluorides for the prevention of white spots on teeth during fixed brace treatment. Cochrane Database Syst Rev. 2004;3:CD003809.
    1. Srivastava K, Tikku T, Khanna R, Sachan K. Risk factors and management of white spot lesions in orthodontics. J Orthod Sci. 2013;2:43–9.
    1. Benson PE, Pender N, Higham SM. Quantifying enamel demineralization from teeth with orthodontic brackets – A comparison of two methods. Part 2: Validity. Eur J Orthod. 2003;25:159–65.
    1. Marinho VC, Worthington HV, Walsh T, Clarkson JE. Fluoride varnishes for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2013;7:CD002279.
    1. Azarpazhooh A, Limeback H. Clinical efficacy of casein derivatives: A systematic review of the literature. J Am Dent Assoc. 2008;139:915–24.
    1. Vivaldi-Rodrigues G, Demito CF, Bowman SJ, Ramos AL. The effectiveness of a fluoride varnish in preventing the development of white spot lesions. World J Orthod. 2006;7:138–44.
    1. Perrini F, Lombardo L, Arreghini A, Medori S, Siciliani G. Caries prevention during orthodontic treatment: In-vivo assessment of high-fluoride varnish to prevent white spot lesions. Am J Orthod Dentofacial Orthop. 2016;149:238–43.
    1. Kirschneck C, Christl JJ, Reicheneder C, Proff P. Efficacy of fluoride varnish for preventing white spot lesions and gingivitis during orthodontic treatment with fixed appliances-a prospective randomized controlled trial. Clin Oral Investig. 2016;20:2371–8.
    1. Turner PJ. The clinical evaluation of a fluoride-containing orthodontic bonding material. Br J Orthod. 1993;20:307–13.
    1. Banks PA, Burn A, O’Brien K. A clinical evaluation of the effectiveness of including fluoride into an orthodontic bonding adhesive. Eur J Orthod. 1997;19:391–5.
    1. Millett DT, McCluskey LA, McAuley F, Creanor SL, Newell J, Love J. A comparative clinical trial of a compomer and a resin adhesive for orthodontic bonding. Angle Orthod. 2000;70:233–40.
    1. Marcusson A, Norevall LI, Persson M. White spot reduction when using glass ionomer cement for bonding in orthodontics: A longitudinal and comparative study. Eur J Orthod. 1997;19:233–42.
    1. Vahid-Dastjerdi E, Borzabadi-Farahani A, Pourmofidi-Neistanak H, Amini N. An in-vitro assessment of weekly cumulative fluoride release from three glass ionomer cements used for orthodontic banding. Prog Orthod. 2012;13:49–56.
    1. Norevall LI, Marcusson A, Persson M. A clinical evaluation of a glass ionomer cement as an orthodontic bonding adhesive compared with an acrylic resin. Eur J Orthod. 1996;18:373–84.
    1. Khoroushi M, Keshani F. A review of glass-ionomers: From conventional glass-ionomer to bioactive glass-ionomer. Dent Res J (Isfahan) 2013;10:411–20.
    1. Banks PA, Chadwick SM, Asher-McDade C, Wright JL. Fluoride-releasing elastomerics – A prospective controlled clinical trial. Eur J Orthod. 2000;22:401–7.
    1. Mattick CR, Mitchell L, Chadwick SM, Wright J. Fluoride-releasing elastomeric modules reduce decalcification: A randomized controlled trial. J Orthod. 2001;28:217–9.
    1. Miethke RR. Comment on determination of fluoride from ligature ties. Am J Orthod Dentofacial Orthop. 1997;111:33A.
    1. Burbank BD, Slater M, Kava A, Doyle J, McHale WA, Latta MA, et al. Ion release, fluoride charge of and adhesion of an orthodontic cement paste containing microcapsules. J Dent. 2016;45:32–8.
    1. Pessan JP, Al-Ibrahim NS, Buzalaf MA, Toumba KJ. Slow-release fluoride devices: A literature review. J Appl Oral Sci. 2008;16:238–46.
    1. Marini I, Pelliccioni GA, Vecchiet F, Alessandri Bonetti G, Checchi L. A retentive system for intra-oral fluoride release during orthodontic treatment. Eur J Orthod. 1999;21:695–701.
    1. Garcia-Godoy F. Shear bond strength of a resin composite to enamel treated with an APF gel. Pediatr Dent. 1993;15:272–4.
    1. Pithon MM, Santos Mde J, de Souza CA, Leão Filho JC, Braz AK, de Araujo RE, et al. Effectiveness of fluoride sealant in the prevention of carious lesions around orthodontic brackets: An OCT evaluation. Dental Press J Orthod. 2015;20:37–42.
    1. Fontana M. Enhancing fluoride: Clinical human studies of alternatives or boosters for caries management. Caries Res. 2016;50(Suppl 1):22–37.
    1. Reynolds EC. Casein phosphopeptide-amorphous calcium phosphate: The scientific evidence. Adv Dent Res. 2009;21:25–9.
    1. Shen P, Cai F, Nowicki A, Vincent J, Reynolds EC. Remineralization of enamel subsurface lesions by sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate. J Dent Res. 2001;80:2066–70.
    1. Cross K, Huq N, Stanton D, Sum M, Reynolds E. NMR studies of a novel calcium, phosphate and fluoride delivery vehicle-α S1-casein (59-79) by stabilized amorphous calcium fluoride phosphate nanocomplexes. Biomaterials. 2004;25:5061–9.
    1. Iijima Y, Cai F, Shen P, Walker G, Reynolds C, Reynolds EC. Acid resistance of enamel subsurface lesions remineralized by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate. Caries Res. 2004;38:551–6.
    1. Cochrane NJ, Cai F, Huq NL, Burrow MF, Reynolds EC. New approaches to enhanced remineralization of tooth enamel. J Dent Res. 2010;89:1187–97.
    1. Cochrane NJ, Reynolds EC. Calcium phosphopeptides – Mechanisms of action and evidence for clinical efficacy. Adv Dent Res. 2012;24:41–7.
    1. Frencken JE, Peters MC, Manton DJ, Leal SC, Gordan VV, Eden E. Minimal intervention dentistry for managing dental caries – A review: Report of a FDI task group. Int Dent J. 2012;62:223–43.
    1. Lynch RJ, Smith SR. Remineralization agents – New and effective or just marketing hype? Adv Dent Res. 2012;24:63–7.
    1. Robertson MA, Kau CH, English JD, Lee RP, Powers J, Nguyen JT. MI paste plus to prevent demineralization in orthodontic patients: A prospective randomized controlled trial. Am J Orthod Dentofacial Orthop. 2011;140:660–8.
    1. Uysal T, Amasyali M, Koyuturk AE, Ozcan S. Effects of different topical agents on enamel demineralization around orthodontic brackets: An in vivo and in vitro study. Aust Dent J. 2010;55:268–74.
    1. Wen-Dan H, Ying-Zhi L, Yuan-Yuan X, Dong C. Study on application of CPP-ACP on tooth mineralization during orthodontic treatment with fixed appliance. Shanghai J Stomatol. 2010;19:140–3.
    1. Beerens MW, van der Veen MH, van Beek H, ten Cate JM. Effects of casein phosphopeptide amorphous calcium fluoride phosphate paste on white spot lesions and dental plaque after orthodontic treatment: A 3-month follow-up. Eur J Oral Sci. 2010;118:610–7.
    1. Bröchner A, Christensen C, Kristensen B, Tranæus S, Karlsson L, Sonnesen L, et al. Treatment of post-orthodontic white spot lesions with casein phosphopeptide-stabilised amorphous calcium phosphate. Clin Oral Investig. 2011;15:369–73.
    1. Pithon MM, Dos Santos MJ, Andrade CS, Leão Filho JC, Braz AK, de Araujo RE, et al. Effectiveness of varnish with CPP-ACP in prevention of caries lesions around orthodontic brackets: An OCT evaluation. Eur J Orthod. 2015;37:177–82.
    1. Andersson A, Sköld-Larsson K, Hallgren A, Petersson LG, Twetman S. Effect of a dental cream containing amorphous cream phosphate complexes on white spot lesion regression assessed by laser fluorescence. Oral Health Prev Dent. 2007;5:229–33.
    1. Ellwood R, Fejerskov O, Cury J, Clarkson B, Kidd E. Dental Caries: The Disease and Its Clinical Management. 2nd ed. Oxford; Ames, Iowa: Blackwell and Munksgaard Oxford; 2008.
    1. Keçik D, Cehreli SB, Sar C, Unver B. Effect of acidulated phosphate fluoride and casein phosphopeptide-amorphous calcium phosphate application on shear bond strength of orthodontic brackets. Angle Orthod. 2008;78:129–33.
    1. Uysal T, Amasyali M, Ozcan S, Koyuturk AE, Akyol M, Sagdic D. In vivo effects of amorphous calcium phosphate-containing orthodontic composite on enamel demineralization around orthodontic brackets. Aust Dent J. 2010;55:285–91.
    1. Lopatiene K, Borisovaite M, Lapenaite E. Prevention and treatment of white spot lesions during and after treatment with fixed orthodontic appliances: A systematic literature review. J Oral Maxillofac Res. 2016;7:e1.
    1. Twetman S, Keller MK. Probiotics for caries prevention and control. Adv Dent Res. 2012;24:98–102.
    1. Fontana M, González-Cabezas C. Are we ready for definitive clinical guidelines on xylitol/polyol use? Adv Dent Res. 2012;24:123–8.
    1. Milgrom P, Söderling EM, Nelson S, Chi DL, Nakai Y. Clinical evidence for polyol efficacy. Adv Dent Res. 2012;24:112–6.
    1. Pickett FA. Nonfluoride caries-preventive agents: New guidelines. J Contemp Dent Pract. 2011;12:469–74.
    1. Sengun A, Sari Z, Ramoglu SI, Malkoç S, Duran I. Evaluation of the dental plaque pH recovery effect of a xylitol lozenge on patients with fixed orthodontic appliances. Angle Orthod. 2004;74:240–4.
    1. Jenatschke F, Elsenberger E, Welte HD, Schlagenhauf U. Influence of repeated chlorhexidine varnish applications on mutans streptococci counts and caries increment in patients treated with fixed orthodontic appliances. J Orofac Orthop. 2001;62:36–45.
    1. Kronenberg O, Lussi A, Ruf S. Preventive effect of ozone on the development of white spot lesions during multibracket appliance therapy. Angle Orthod. 2009;79:64–9.
    1. Øgaard B, Larsson E, Henriksson T, Birkhed D, Bishara SE. Effects of combined application of antimicrobial and fluoride varnishes in orthodontic patients. Am J Orthod Dentofacial Orthop. 2001;120:28–35.
    1. Karandish M. The efficiency of laser application on the enamel surface: A systematic review. J Lasers Med Sci. 2014;5:108–14.
    1. Olivi G, Genovese MD, Caprioglio C. Evidence-based dentistry on laser paediatric dentistry: Review and outlook. Eur J Paediatr Dent. 2009;10:29–40.
    1. Verma SK, Maheshwari S, Singh RK, Chaudhari PK. Laser in dentistry: An innovative tool in modern dental practice. Natl J Maxillofac Surg. 2012;3:124–32.
    1. Fox JL, Yu D, Otsuka M, Higuchi WI, Wong J, Powell GL. Initial dissolution rate studies on dental enamel after CO2 laser irradiation. J Dent Res. 1992;71:1389–98.
    1. Noel L, Rebellato J, Sheats RD. The effect of argon laser irradiation on demineralization resistance of human enamel adjacent to orthodontic brackets: An in vitro study. Angle Orthod. 2003;73:249–58.
    1. Meeran NA. Iatrogenic possibilities of orthodontic treatment and modalities of prevention. J Orthod Sci. 2013;2:73–86.
    1. Ahrari F, Poosti M, Motahari P. Enamel resistance to demineralization following Er:YAG laser etching for bonding orthodontic brackets. Dent Res J (Isfahan) 2012;9:472–7.
    1. Esteves-Oliveira M, Pasaporti C, Heussen N, Eduardo CP, Lampert F, Apel C. Rehardening of acid-softened enamel and prevention of enamel softening through CO2 laser irradiation. J Dent. 2011;39:414–21.
    1. Liu JF, Liu Y, Stephen HC. Optimal Er:YAG laser energy for preventing enamel demineralization. J Dent. 2006;34:62–6.
    1. Rodrigues LK, Nobre dos Santos M, Pereira D, Assaf AV, Pardi V. Carbon dioxide laser in dental caries prevention. J Dent. 2004;32:531–40.
    1. Steiner-Oliveira C, Nobre-dos-Santos M, Zero DT, Eckert G, Hara AT. Effect of a pulsed CO2 laser and fluoride on the prevention of enamel and dentine erosion. Arch Oral Biol. 2010;55:127–33.
    1. Guzmán-Armstrong S, Chalmers J, Warren JJ. Ask us. White spot lesions: Prevention and treatment. Am J Orthod Dentofacial Orthop. 2010;138:690–6.
    1. Benson PE, Shah AA, Millett DT, Dyer F, Parkin N, Vine RS. Fluorides, orthodontics and demineralization: A systematic review. J Orthod. 2005;32:102–14.
    1. Mota SM, Enoki C, Ito IY, Elias AM, Matsumoto MA. Streptococcus mutans counts in plaque adjacent to orthodontic brackets bonded with resin-modified glass ionomer cement or resin-based composite. Braz Oral Res. 2008;22:55–60.
    1. Denis M, Atlan A, Vennat E, Tirlet G, Attal JP. White defects on enamel: Diagnosis and anatomopathology: Two essential factors for proper treatment (part 1) Int Orthod. 2013;11:139–65.
    1. Sonesson M, Bergstrand F, Gizani S, Twetman S. Management of post-orthodontic white spot lesions: An updated systematic review. Eur J Orthod. 2016 pii: Cjw023.
    1. Senestraro SV, Crowe JJ, Wang M, Vo A, Huang G, Ferracane J, et al. Minimally invasive resin infiltration of arrested white-spot lesions: A randomized clinical trial. J Am Dent Assoc. 2013;144:997–1005.
    1. Kim Y, Son HH, Yi K, Ahn JS, Chang J. Bleaching effects on color, chemical, and mechanical properties of white spot lesions. Oper Dent. 2016;41:318–26.
    1. Khoroushi M, Mazaheri H, Saneie T, Samimi P. Fracture toughness of bleached enamel: Effect of applying three different nanobiomaterials by nanoindentation test. Contemp Clin Dent. 2016;7:209–15.
    1. Khoroushi M, Shirban F, Doustfateme S, Kaveh S. Effect of three nanobiomaterials on the surface roughness of bleached enamel. Contemp Clin Dent. 2015;6:466–70.
    1. Yetkiner E, Wegehaupt F, Wiegand A, Attin R, Attin T. Colour improvement and stability of white spot lesions following infiltration, micro-abrasion, or fluoride treatments in vitro. Eur J Orthod. 2014;36:595–602.
    1. Sundfeld RH, Croll TP, Briso AL, de Alexandre RS, Sundfeld Neto D. Considerations about enamel microabrasion after 18 years. Am J Dent. 2007;20:67–72.
    1. Kim S, Kim EY, Jeong TS, Kim JW. The evaluation of resin infiltration for masking labial enamel white spot lesions. Int J Paediatr Dent. 2011;21:241–8.
    1. Eckstein A, Helms HJ, Knösel M. Camouflage effects following resin infiltration of postorthodontic white-spot lesions in vivo: One-year follow-up. Angle Orthod. 2015;85:374–80.
    1. Knösel M, Eckstein A, Helms HJ. Durability of esthetic improvement following Icon resin infiltration of multibracket-induced white spot lesions compared with no therapy over 6 months: A single-center, split-mouth, randomized clinical trial. Am J Orthod Dentofacial Orthop. 2013;144:86–96.
    1. Tirlet G, Chabouis HF, Attal JP. Infiltration, a new therapy for masking enamel white spots: A 19-month follow-up case series. Eur J Esthet Dent. 2013;8:180–90.

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