Physical activity in older age: perspectives for healthy ageing and frailty

Jamie S McPhee, David P French, Dean Jackson, James Nazroo, Neil Pendleton, Hans Degens, Jamie S McPhee, David P French, Dean Jackson, James Nazroo, Neil Pendleton, Hans Degens

Abstract

Regular physical activity helps to improve physical and mental functions as well as reverse some effects of chronic disease to keep older people mobile and independent. Despite the highly publicised benefits of physical activity, the overwhelming majority of older people in the United Kingdom do not meet the minimum physical activity levels needed to maintain health. The sedentary lifestyles that predominate in older age results in premature onset of ill health, disease and frailty. Local authorities have a responsibility to promote physical activity amongst older people, but knowing how to stimulate regular activity at the population-level is challenging. The physiological rationale for physical activity, risks of adverse events, societal and psychological factors are discussed with a view to inform public health initiatives for the relatively healthy older person as well as those with physical frailty. The evidence shows that regular physical activity is safe for healthy and for frail older people and the risks of developing major cardiovascular and metabolic diseases, obesity, falls, cognitive impairments, osteoporosis and muscular weakness are decreased by regularly completing activities ranging from low intensity walking through to more vigorous sports and resistance exercises. Yet, participation in physical activities remains low amongst older adults, particularly those living in less affluent areas. Older people may be encouraged to increase their activities if influenced by clinicians, family or friends, keeping costs low and enjoyment high, facilitating group-based activities and raising self-efficacy for exercise.

Keywords: Exercise; Falls; Frailty; Health; Muscle; Physical activity.

Figures

Fig. 1
Fig. 1
Schematic representation of ageing trajectories and individual exercise needs. Good physiological function is maintained until middle age and thereafter progressively deteriorates. The upper horizontal dashed line represents a theoretical point at which deterioration manifests as moderate functional deficits and above this line the general aim of physical activity is to maintain good health. The lower horizontal dashed line indicates a theoretical threshold beyond which a person suffers disability and frailty, so the aim of physical activity is to recover the deficits and improve mobility. The curved lines represent a accelerated ageing, b normal ageing and c healthy ageing. Exercise interventions should match the physical capability, rather than chronological age per se to be effective
Fig. 2
Fig. 2
Physical Activity Participation in UK adults. With increasing age, sports participation progressively declines. Walking for health benefits or enjoyment remains fairly constant amongst young and middle-aged adults, but declines progressively into older age. Amongst those who are sedentary, more of the younger adults have a desire to increase physical activity levels compared with the middle-aged and the old. Data are from The Taking Part Survey, which interviewed >92,000 people in England between 2005 and 2009 to ask about physical activity habits (Department for Culture 2011)

References

    1. ACSM American College of Sports Medicine Position Stand. Exercise and physical activity for older adults Med Sci Sports Exerc. 1998;30:992–1008.
    1. Age UK (2010) Healthy ageing evidence review. . Accessed 8 June 2015
    1. Age UK (2015) A practical guide to healthy ageing. . Accessed 08 July 2015
    1. Ashfield TA, Syddall HE, Martin HJ, Dennison EM, Cooper C, Aihie Sayer A. Grip strength and cardiovascular drug use in older people: findings from the Hertfordshire cohort study. Age Ageing. 2010;39:185–191. doi: 10.1093/ageing/afp203.
    1. Bandura A. Self-efficacy: the exercise of control. New York: Freeman; 1997.
    1. Banks J, Breeze E, Lessof C, Nazroo J (2006) Retirement, health and relationships of the older population in England: the 2004 English longitudinal study of ageing. The Institute for Fiscal Studies, London. ISBN 1 903274 46 X
    1. Bauer JM. Effects of a vitamin D and leucine-enriched whey protein oral nutrition supplement on measures of sarcopenia in older adults. The PROVIDE study: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc. 2015;16(9):740–747. doi: 10.1016/j.jamda.2015.05.021.
    1. Beijersbergen CM, Granacher U, Vandervoort AA, DeVita P, Hortobagyi T. The biomechanical mechanism of how strength and power training improves walking speed in old adults remains unknown. Ageing Res Rev. 2013;12:618–627. doi: 10.1016/j.arr.2013.03.001.
    1. Berk DR, Hubert HB, Fries JF. Associations of changes in exercise level with subsequent disability among seniors: a 16-year longitudinal study. J Gerontol Ser A. 2006;61:97–102. doi: 10.1093/gerona/61.1.97.
    1. Bijlsma AY, Meskers CG, van den Eshof N, Westendorp RG, Sipila S, Stenroth L, Sillanpaa E, McPhee JS, Jones DA, Narici MV, Gapeyeva H, Paasuke M, Voit T, Barnouin Y, Hogrel JY, Butler-Browne G, Maier AB. Diagnostic criteria for sarcopenia and physical performance. Age. 2013
    1. Bijlsma AY, Meskers MC, Molendijk M, Westendorp RG, Sipila S, Stenroth L, Sillanpaa E, McPhee JS, Jones DA, Narici M, Gapeyeva H, Paasuke M, Seppet E, Voit T, Barnouin Y, Hogrel JY, Butler-Browne G, Maier AB. Diagnostic measures for sarcopenia and bone mineral density. Osteoporos Int. 2013;24:2681–2691. doi: 10.1007/s00198-013-2376-8.
    1. Booth FW, Gordon SE, Carlson CJ, Hamilton MT. Waging war on modern chronic diseases: primary prevention through exercise biology. J Appl Physiol. 2000;88:774–787.
    1. Borjesson M, Urhausen A, Kouidi E, Dugmore D, Sharma S, Halle M, Heidbuchel H, Bjornstad HH, Gielen S, Mezzani A, Corrado D, Pelliccia A, Vanhees L. Cardiovascular evaluation of middle-aged/senior individuals engaged in leisure-time sport activities: position stand from the sections of exercise physiology and sports cardiology of the European Association of Cardiovascular Prevention and Rehabilitation. Eur J Cardiovasc Prev Rehabil. 2011;18:446–458. doi: 10.1097/HJR.0b013e32833bo969.
    1. British Geriatric Society (2014) Fit for frailty: consensus best practice guidance for the care of older people living with frailty in community and outpatient settings. . Accessed Feb 2016
    1. Bruce B, Fries JF, Hubert H. Regular vigorous physical activity and disability development in healthy overweight and normal-weight seniors: a 13-year study. Am J Public Health. 2008;98:1294–1299. doi: 10.2105/AJPH.2007.119909.
    1. Buchner DM, Cress ME, de Lateur BJ, Esselman PC, Margherita AJ, Price R, Wagner EH. The effect of strength and endurance training on gait, balance, fall risk, and health services use in community-living older adults. J Gerontol Ser A. 1997;52:M218–M224. doi: 10.1093/gerona/52A.4.M218.
    1. Campbell MJ, McComas AJ, Petito F. Physiological changes in ageing muscles. J Neurol Neurosurg Psychiatry. 1973;36:174–182. doi: 10.1136/jnnp.36.2.174.
    1. Campbell K, Foster-Schubert K, Xiao L, Alfano C, Bertram LC, Duggan C, Irwin M, McTiernan A. Injuries in sedentary individuals enrolled in a 12-month, randomized, controlled, exercise trial. J Phys Act Health. 2012;9:198–207.
    1. Chin APMJ, van Poppel MN, Twisk JW, van Mechelen W. Effects of resistance and all-round, functional training on quality of life, vitality and depression of older adults living in long-term care facilities: a ‘randomized’ controlled trial [ISRCTN87177281] BMC Geriatr. 2004;4:5. doi: 10.1186/1471-2318-4-5.
    1. Chin APMJ, van Poppel MN, van Mechelen W. Effects of resistance and functional-skills training on habitual activity and constipation among older adults living in long-term care facilities: a randomized controlled trial. BMC Geriatr. 2006;6:9. doi: 10.1186/1471-2318-6-9.
    1. Chou WT, Tomata Y, Watanabe T, Sugawara Y, Kakizaki M, Tsuji I. Relationships between changes in time spent walking since middle age and incident functional disability. Prev Med. 2014;59:68–72. doi: 10.1016/j.ypmed.2013.11.019.
    1. Church TS, Earnest CP, Skinner JS, Blair SN. Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trial. JAMA. 2007;297:2081–2091. doi: 10.1001/jama.297.19.2081.
    1. Clark DO. The effect of walking on lower body disability among older blacks and whites. Am J Public Health. 1996;86:57–61. doi: 10.2105/AJPH.86.1.57.
    1. Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381:752–762. doi: 10.1016/S0140-6736(12)62167-9.
    1. Crocker T, Forster A, Young J, Brown L, Ozer S, Smith J, Green J, Hardy J, Burns E, Glidewell E, Greenwood DC. Physical rehabilitation for older people in long-term care. Cochrane Database Syst Rev. 2013;2:CD004294.
    1. Daniels R, van Rossum E, de Witte L, Kempen GI, van den Heuvel W. Interventions to prevent disability in frail community-dwelling elderly: a systematic review. BMC Health Serv Res. 2008;8:278. doi: 10.1186/1472-6963-8-278.
    1. Darker CD, French DP, Eves FF, Sniehotta FF. An intervention to promote walking amongst the general population based on an ‘extended’ theory of planned behaviour: a waiting list randomised controlled trial. Psychol Health. 2010;25:71–88. doi: 10.1080/08870440902893716.
    1. Davidson LE, Hudson R, Kilpatrick K, Kuk JL, McMillan K, Janiszewski PM, Lee S, Lam M, Ross R. Effects of exercise modality on insulin resistance and functional limitation in older adults: a randomized controlled trial. Arch Intern Med. 2009;169:122–131. doi: 10.1001/archinternmed.2008.558.
    1. Degens H, Maden-Wilkinson TM, Ireland A, Korhonen MT, Suominen H, Heinonen A, Radak Z, McPhee JS, Rittweger J. Relationship between ventilatory function and age in master athletes and a sedentary reference population. Age. 2013;35:1007–1015. doi: 10.1007/s11357-012-9409-7.
    1. Degens H, Rittweger J, Parviainen T, Timonen KL, Suominen H, Heinonen A, Korhonen MT. Diffusion capacity of the lung in young and old endurance athletes. Int J Sports Med. 2013;34:1051–1057. doi: 10.1055/s-0033-1345137.
    1. Department for Culture MaS (2011) Adult participation in sport: analysis of the taking part survey. . Accessed 10 July 2015
    1. Department of Health UK (2011) Start active, stay active: UK Physical Activity Guidelines. Department of Health, UK
    1. Devereux-Fitzgerald A, Powell R, Dewhurst A, French D (2016) The acceptability of physical activity interventions to older adults: a systematic review and meta-synthesis. Soc Sci Med (in press)
    1. Dufour AB, Hannan MT, Murabito JM, Kiel DP, McLean RR. Sarcopenia definitions considering body size and fat mass are associated with mobility limitations: the Framingham study. J Gerontol Ser A. 2013;68:168–174. doi: 10.1093/gerona/gls109.
    1. Dunn AL, Marcus BH, Kampert JB, Garcia ME, Kohl HW, 3rd, Blair SN. Comparison of lifestyle and structured interventions to increase physical activity and cardiorespiratory fitness: a randomized trial. JAMA. 1999;281:327–334. doi: 10.1001/jama.281.4.327.
    1. Earnest CP, Johannsen NM, Swift DL, Lavie CJ, Blair SN, Church TS. Dose effect of cardiorespiratory exercise on metabolic syndrome in postmenopausal women. Am J Cardiol. 2013;111:1805–1811. doi: 10.1016/j.amjcard.2013.02.037.
    1. Ebrahim S, Wannamethee SG, Whincup P, Walker M, Shaper AG. Locomotor disability in a cohort of British men: the impact of lifestyle and disease. Int J Epidemiol. 2000;29:478–486. doi: 10.1093/ije/29.3.478.
    1. Eurostat (2014) Projected old-age dependency ratio (tsdde511)
    1. Eurostat (2015) Deaths and life expectancy data. . Accessed 15 Feb 2016
    1. Evans GW, Kantrowitz E. Socioeconomic status and health: the potential role of environmental risk exposure. Annu Rev Public Health. 2002;23:303–331. doi: 10.1146/annurev.publhealth.23.112001.112349.
    1. Evans GW, Kim P. Multiple risk exposure as a potential explanatory mechanism for the socioeconomic status-health gradient. Ann N Y Acad Sci. 2010;1186:174–189. doi: 10.1111/j.1749-6632.2009.05336.x.
    1. Feldman DI, Al-Mallah MH, Keteyian SJ, Brawner CA, Feldman T, Blumenthal RS, Blaha MJ. No evidence of an upper threshold for mortality benefit at high levels of cardiorespiratory fitness. J Am Coll Cardiol. 2015;65:629–630. doi: 10.1016/j.jacc.2014.11.030.
    1. Ferrucci L, Izmirlian G, Leveille S, Phillips CL, Corti MC, Brock DB, Guralnik JM. Smoking, physical activity, and active life expectancy. Am J Epidemiol. 1999;149:645–653. doi: 10.1093/oxfordjournals.aje.a009865.
    1. Fiatarone MA, Marks EC, Ryan ND, Meredith CN, Lipsitz LA, Evans WJ. High-intensity strength training in nonagenarians. Effects on skeletal muscle. JAMA. 1990;263:3029–3034. doi: 10.1001/jama.1990.03440220053029.
    1. Fielding RA, Katula J, Miller ME, Abbott-Pillola K, Jordan A, Glynn NW, Goodpaster B, Walkup MP, King AC, Rejeski WJ. Activity adherence and physical function in older adults with functional limitations. Med Sci Sports Exerc. 2007;39:1997–2004. doi: 10.1249/mss.0b013e318145348d.
    1. Forbes D, Thiessen EJ, Blake CM, Forbes SC, Forbes S. Exercise programs for people with dementia. Cochrane Database Syst Rev. 2013;12:CD006489.
    1. Forster A, Lambley R, Young JB. Is physical rehabilitation for older people in long-term care effective? Findings from a systematic review. Age Ageing. 2010;39:169–175. doi: 10.1093/ageing/afp247.
    1. Franco MR, Pereira LS, Ferreira PH. Exercise interventions for preventing falls in older people living in the community. Br J Sports Med. 2014;48:867–868. doi: 10.1136/bjsports-2012-092065.
    1. French DP. The role of self-efficacy in changing health-related behaviour: cause, effect or spurious association? Br J Health Psychol. 2013;18:237–243. doi: 10.1111/bjhp.12038.
    1. French DP, Olander EK, Chisholm A, Mc Sharry J. Which behaviour change techniques are most effective at increasing older adults’ self-efficacy and physical activity behaviour? A systematic review. Ann Behav Med. 2014;48:225–234. doi: 10.1007/s12160-014-9593-z.
    1. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA. Frailty in older adults: evidence for a phenotype. J Gerontol Ser A. 2001;56:M146–M156. doi: 10.1093/gerona/56.3.M146.
    1. Ganse B, Degens H, Drey M, Korhonen MT, McPhee J, Muller K, Johannes BW, Rittweger J. Impact of age, performance and athletic event on injury rates in master athletics - first results from an ongoing prospective study. J Musculoskelet Neuron Interactions. 2014;14:148–154.
    1. Ganz DA, Bao Y, Shekelle PG, Rubenstein LZ. Will my patient fall? JAMA. 2007;297:77–86. doi: 10.1001/jama.297.1.77.
    1. Gardner B. Promoting habit formation. Health Psychol Rev. 2013;7(supplement):137–158.
    1. Gill TM, Allore HG, Hardy SE, Guo Z. The dynamic nature of mobility disability in older persons. J Am Geriatr Soc. 2006;54:248–254. doi: 10.1111/j.1532-5415.2005.00586.x.
    1. Gillespie LD, Robertson MC, Gillespie WJ, Sherrington C, Gates S, Clemson LM, Lamb SE. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev. 2012;9:CD007146.
    1. Hamer M, Lavoie KL, Bacon SL. Taking up physical activity in later life and healthy ageing: the English longitudinal study of ageing. Br J Sports Med. 2014;48:239–243. doi: 10.1136/bjsports-2013-092993.
    1. Hardy SE, Gill TM. Recovery from disability among community-dwelling older persons. JAMA. 2004;291:1596–1602. doi: 10.1001/jama.291.13.1596.
    1. Harridge SD, Kryger A, Stensgaard A. Knee extensor strength, activation, and size in very elderly people following strength training. Muscle Nerve. 1999;22:831–839. doi: 10.1002/(SICI)1097-4598(199907)22:7<831::AID-MUS4>;2-3.
    1. Health USDo Physical Activity Guidelines Advisory Committee report, 2008. To the Secretary of Health and Human Services Part A: executive summary. Nutr Rev. 2009;67:114–120. doi: 10.1111/j.1753-4887.2008.00136.x.
    1. Healy GN, Dunstan DW, Salmon J, Cerin E, Shaw JE, Zimmet PZ, Owen N. Breaks in sedentary time: beneficial associations with metabolic risk. Diabetes Care. 2008;31:661–666. doi: 10.2337/dc07-2046.
    1. Holviala J, Kraemer WJ, Sillanpaa E, Karppinen H, Avela J, Kauhanen A, Hakkinen A, Hakkinen K. Effects of strength, endurance and combined training on muscle strength, walking speed and dynamic balance in aging men. Eur J Appl Physiol. 2012;112:1335–1347. doi: 10.1007/s00421-011-2089-7.
    1. Howe TE, Rochester L, Jackson A, Banks PM, Blair VA. Exercise for improving balance in older people. Cochrane Database Syst Rev. 2007
    1. Huang G, Gibson CA, Tran ZV, Osness WH. Controlled endurance exercise training and VO2max changes in older adults: a meta-analysis. Prev Cardiol. 2005;8:217–225. doi: 10.1111/j.0197-3118.2005.04324.x.
    1. Hunt K, Wyke S, Gray CM, Anderson AS, Brady A, Bunn C, Donnan PT, Fenwick E, Grieve E, Leishman J, Miller E, Mutrie N, Rauchhaus P, White A, Treweek S. A gender-sensitised weight loss and healthy living programme for overweight and obese men delivered by Scottish Premier League football clubs (FFIT): a pragmatic randomised controlled trial. Lancet. 2014;383:1211–1221. doi: 10.1016/S0140-6736(13)62420-4.
    1. Iparraguirre J. Physical Functioning in work and retirement: commentary on age-related trajectories of physical functioning in work and retirement –the role of sociodemographic factors, lifestyle and disease by Stenholm et al. J Epidemiol Commun Health. 2014;68:493–499. doi: 10.1136/jech-2014-203945.
    1. Ireland A, Maden-Wilkinson T, Ganse B, Degens H, Rittweger J. Effects of age and starting age upon side asymmetry in the arms of veteran tennis players: a cross-sectional study. Osteoporos Int. 2014;25:1389–1400. doi: 10.1007/s00198-014-2617-5.
    1. Jones CJ, Rikli RE, Beam WC. A 30-s chair-stand test as a measure of lower body strength in community-residing older adults. Res Quart Exerc Sport. 1999;70:113–119. doi: 10.1080/02701367.1999.10608028.
    1. Kassavou A, Turner A, French DP. Do interventions to promote walking in groups increase physical activity? A meta-analysis. Int J Behav Nutr Phys Act. 2013;10:18. doi: 10.1186/1479-5868-10-18.
    1. Kassavou A, Turner A, Hamborg T, French DP. Predicting maintenance of attendance at walking groups: testing constructs from three leading maintenance theories. Health Psychol. 2014;33:752–756. doi: 10.1037/hea0000015.
    1. Kim JH, Malhotra R, Chiampas G, d’Hemecourt P, Troyanos C, Cianca J, Smith RN, Wang TJ, Roberts WO, Thompson PD, Baggish AL. Cardiac arrest during long-distance running races. N Engl J Med. 2012;366:130–140. doi: 10.1056/NEJMoa1106468.
    1. Kim LG, Adamson J, Ebrahim S. Influence of life-style choices on locomotor disability, arthritis and cardiovascular disease in older women: prospective cohort study. Age Ageing. 2013;42:696–701. doi: 10.1093/ageing/aft127.
    1. King AC, Baumann K, O’Sullivan P, Wilcox S, Castro C. Effects of moderate-intensity exercise on physiological, behavioral, and emotional responses to family caregiving: a randomized controlled trial. J Gerontol Ser A. 2002;57:M26–M36. doi: 10.1093/gerona/57.1.M26.
    1. Koeneman MA, Verheijden MW, Chinapaw MJ, Hopman-Rock M. Determinants of physical activity and exercise in healthy older adults: a systematic review. Int J Behav Nutr Phys Act. 2011;8:142. doi: 10.1186/1479-5868-8-142.
    1. Lautenschlager NT, Cox KL, Flicker L, Foster JK, van Bockxmeer FM, Xiao J, Greenop KR, Almeida OP. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. J Am Med Assoc. 2008;300:1027–1037. doi: 10.1001/jama.300.9.1027.
    1. Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet. 2012;380:219–229. doi: 10.1016/S0140-6736(12)61031-9.
    1. Lexell J, Taylor CC, Sjostrom M. What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J Neurol Sci. 1988;84:275–294. doi: 10.1016/0022-510X(88)90132-3.
    1. Liu CJ, Latham NK. Progressive resistance strength training for improving physical function in older adults. Cochrane Database Syst Rev. 2009
    1. Liu CJ, Latham N. Adverse events reported in progressive resistance strength training trials in older adults: 2 sides of a coin. Arch Phys Med Rehabil. 2010;91:1471–1473. doi: 10.1016/j.apmr.2010.06.001.
    1. Lockenhoff CE, Carstensen LL. Socioemotional selectivity theory, aging, and health: the increasingly delicate balance between regulating emotions and making tough choices. J Pers. 2004;72:1395–1424. doi: 10.1111/j.1467-6494.2004.00301.x.
    1. Maden-Wilkinson TM, McPhee JS, Rittweger J, Jones DA, Degens H. Thigh muscle volume in relation to age, sex and femur volume. Age. 2013
    1. Maden-Wilkinson TM, McPhee JS, Jones DA, Degens H. Age related loss of muscle mass, Strength and power and their association with mobility in recreationally active UK older adults. J Aging Phys Act. 2014
    1. Manini TM, Everhart JE, Patel KV, Schoeller DA, Colbert LH, Visser M, Tylavsky F, Bauer DC, Goodpaster BH, Harris TB. Daily activity energy expenditure and mortality among older adults. J Am Med Assoc. 2006;296:171–179. doi: 10.1001/jama.296.2.171.
    1. Mann GV, Garrett HL, Farhi A, Murray H, Billings FT. Exercise to prevent coronary heart disease. An experimental study of the effects of training on risk factors for coronary disease in men. Am J Med. 1969;46:12–27. doi: 10.1016/0002-9343(69)90054-0.
    1. Marengoni A, Angleman S, Melis R, Mangialasche F, Karp A, Garmen A, Meinow B, Fratiglioni L. Aging with multimorbidity: a systematic review of the literature. Ageing Res Rev. 2011;10:430–439. doi: 10.1016/j.arr.2011.03.003.
    1. Marmot M, Banks J, Blundell R, Lessof C, Nazroo J (2003) Health, wealth and lifestyles of the older population in England: the 2002 English longitudinal study of ageing. The Institute for Fiscal Studies, London. ISBN 1 903274 34 6
    1. Matthews K, Demakakos P, Nazroo J, Shankar A (2014) The evolution of lifestyles in older age in England. In:, Banks J, Nazroo J, Steptoe A (eds) The dynamics of ageing: evidence from the English longitudinal study of ageing 2002–2012. The Institute for Fiscal Studies, London. ISBN 978-1-909463-58-5, 51-93
    1. McMunn A, Nazroo J, Breeze E. Inequalities in health at older ages: a longitudinal investigation of the onset of illness and survival effects in England. Age Ageing. 2009;38:181–187. doi: 10.1093/ageing/afn236.
    1. McPhee JS, Hogrel JY, Maier AB, Seppet E, Seynnes OR, Sipila S, Bottinelli R, Barnouin Y, Bijlsma AY, Gapeyeva H, Maden-Wilkinson TM, Meskers CG, Paasuke M, Sillanpaa E, Stenroth L, Butler-Browne G, Narici MV, Jones DA. Physiological and functional evaluation of healthy young and older men and women: design of the European MyoAge study. Biogerontology. 2013;14:325–337. doi: 10.1007/s10522-013-9434-7.
    1. Menec VH, Shooshtari S, Nowicki S, Fournier S. Does the relationship between neighborhood socioeconomic status and health outcomes persist into very old age? A population-based study. J Aging Health. 2010;22:27–47. doi: 10.1177/0898264309349029.
    1. Michaelis I, Kwiet A, Gast U, Boshof A, Antvorskov T, Jung T, Rittweger J, Felsenberg D. Decline of specific peak jumping power with age in master runners. J Musculoskelet Neuron Interactions. 2008;8:64–70.
    1. Molino-Lova R, Pasquini G, Vannetti F, Paperini A, Forconi T, Polcaro P, Zipoli R, Cecchi F, Macchi C. Effects of a structured physical activity intervention on measures of physical performance in frail elderly patients after cardiac rehabilitation: a pilot study with 1-year follow-up. Intern Emerg Med. 2013;8:581–589. doi: 10.1007/s11739-011-0654-z.
    1. Nazroo J, Zaninotto P, Gjonça E. Mortality and healthy life expectancy. In: Banks J, Breeze E, Lessof C, Nazroo J, editors. Living in the 21st century: older people in England. The 2006 English longitudinal study of ageing. London: The Institute for Fiscal Studies; 2008. pp. 253–288.
    1. NICE (2009) Rehabilitation after critical illness: NICE guideline National Institute for Health and Clinical Excellence.
    1. ONS (2013) General health (General lifestyle survey overview—a report on the 2011 general lifestyle survey) Office for National Statistics (UK). . Accessed 17 Sep 2014
    1. Orr R, de Vos NJ, Singh NA, Ross DA, Stavrinos TM, Fiatarone-Singh MA. Power training improves balance in healthy older adults. J Gerontol Ser A. 2006;61:78–85. doi: 10.1093/gerona/61.1.78.
    1. Pahor M, Blair SN, Espeland M, Fielding R, Gill TM, Guralnik JM, Hadley EC, King AC, Kritchevsky SB, Maraldi C, Miller ME, Newman AB, Rejeski WJ, Romashkan S, Studenski S. Effects of a physical activity intervention on measures of physical performance: results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study. J Gerontol Ser A. 2006;61:1157–1165. doi: 10.1093/gerona/61.5.472.
    1. Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD. Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA. 2014;311:2387–2396. doi: 10.1001/jama.2014.5616.
    1. Paterson DH, Warburton DE. Physical activity and functional limitations in older adults: a systematic review related to Canada’s physical activity guidelines. Int J Behav Nutr Phys Act. 2010;7:38. doi: 10.1186/1479-5868-7-38.
    1. Pearson SJ, Young A, Macaluso A, Devito G, Nimmo MA, Cobbold M, Harridge SD. Muscle function in elite master weightlifters. Med Sci Sports Exerc. 2002;34:1199–1206. doi: 10.1097/00005768-200207000-00023.
    1. Pereira A, Izquierdo M, Silva AJ, Costa AM, Bastos E, Gonzalez-Badillo JJ, Marques MC. Effects of high-speed power training on functional capacity and muscle performance in older women. Exp Gerontol. 2012;47:250–255. doi: 10.1016/j.exger.2011.12.010.
    1. Piasecki M, Ireland A, Jones DA, McPhee JS. Age-dependent motor unit remodelling in human limb muscles. Biogerontology. 2015
    1. Piasecki M, Ireland A, Stashuk D, Hamilton-Wright A, Jones DA, McPhee JS. Age-related neuromuscular changes affecting human vastus lateralis. J Physiol. 2015
    1. Powell KE, Paluch AE, Blair SN. Physical activity for health: what kind? How much? How intense? On top of what? Annu Rev Public Health. 2011;32:349–365. doi: 10.1146/annurev-publhealth-031210-101151.
    1. Power GA, Dalton BH, Behm DG, Vandervoort AA, Doherty TJ, Rice CL. Motor unit number estimates in masters runners: use it or lose it? Med Sci Sports Exerc. 2010;42:1644–1650. doi: 10.1249/MSS.0b013e3181d6f9e9.
    1. Power GA, Dalton BH, Behm DG, Doherty TJ, Vandervoort AA, Rice CL. Motor unit survival in life-long runners is muscle-dependent. Med Sci Sports Exerc. 2012
    1. Rechel B, Grundy E, Robine JM, Cylus J, Mackenbach JP, Knai C, McKee M. Ageing in the European Union. Lancet. 2013;381:1312–1322. doi: 10.1016/S0140-6736(12)62087-X.
    1. Rikli R, Jones C. The reliability and validity of a 6-min walk test as a measure of physical endurance in older adults. J Ageing Phys Act. 1998;6:363–375.
    1. Rittweger J, di Prampero PE, Maffulli N, Narici MV. Sprint and endurance power and ageing: an analysis of master athletic world records. Proc Biol Sci. 2009;276:683–689. doi: 10.1098/rspb.2008.1319.
    1. Roberts CK, Hevener AL, Barnard RJ. Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. Compr Physiol. 2013;3:1–58.
    1. Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, Mitnitski A. A global clinical measure of fitness and frailty in elderly people. Can Med Assoc J. 2005;173:489–495. doi: 10.1503/cmaj.050051.
    1. Roh KH, Park HA. A meta-analysis of the effect of walking exercise on lower limb muscle endurance, whole body endurance and upper body flexibility in elders. J Korean Acad Nurs. 2013;43:536–546. doi: 10.4040/jkan.2013.43.4.536.
    1. Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr. 1997;127:990S–991S.
    1. Rubenstein LZ, Josephson KR, Trueblood PR, Loy S, Harker JO, Pietruszka FM, Robbins AS. Effects of a group exercise program on strength, mobility, and falls among fall-prone elderly men. J Gerontol Ser A. 2000;55:M317–M321. doi: 10.1093/gerona/55.6.M317.
    1. Runge M, Rittweger J, Russo CR, Schiessl H, Felsenberg D. Is muscle power output a key factor in the age-related decline in physical performance? a comparison of muscle cross section, chair-rising test and jumping power. Clin Physiol Funct Imaging. 2004;24(6):335–340. doi: 10.1111/j.1475-097X.2004.00567.x.
    1. Sabia S, Singh-Manoux A, Hagger-Johnson G, Cambois E, Brunner EJ, Kivimaki M. Influence of individual and combined healthy behaviours on successful aging. Can Med Assoc J. 2012;184:1985–1992. doi: 10.1503/cmaj.121080.
    1. Salas C. On the empirical association between poor health and low socioeconomic status at old age. Health Econ. 2002;11:207–220. doi: 10.1002/hec.663.
    1. Sallinen J, Stenholm S, Rantanen T, Heliovaara M, Sainio P, Koskinen S. Hand-grip strength cut points to screen older persons at risk for mobility limitation. J Am Geriatr Soc. 2010;58(9):1721–1726. doi: 10.1111/j.1532-5415.2010.03035.x.
    1. Sallis J, Owen N. Physical activity and behavioral medicine. Thousand Oaks: Sage; 1998.
    1. Sillanpaa E, Hakkinen A, Nyman K, Mattila M, Cheng S, Karavirta L, Laaksonen DE, Huuhka N, Kraemer WJ, Hakkinen K. Body composition and fitness during strength and/or endurance training in older men. Med Sci Sports Exerc. 2008;40:950–958. doi: 10.1249/MSS.0b013e318165c854.
    1. Sillanpaa E, Hakkinen K, Holviala J, Hakkinen A. Combined strength and endurance training improves health-related quality of life in healthy middle-aged and older adults. Int J Sports Med. 2012;33:981–986. doi: 10.1055/s-0032-1311589.
    1. Sillanpaa E, Stenroth L, Bijlsma AY, Rantanen T, McPhee JS, Maden-Wilkinson TM, Jones DA, Narici MV, Gapeyeva H, Paasuke M, Barnouin Y, Hogrel JY, Butler-Browne GS, Meskers CG, Maier AB, Tormakangas T, Sipila S. Associations between muscle strength, spirometric pulmonary function and mobility in healthy older adults. Age. 2014;36:9667. doi: 10.1007/s11357-014-9667-7.
    1. Siscovick DS, Weiss NS, Fletcher RH, Lasky T. The incidence of primary cardiac arrest during vigorous exercise. N Engl J Med. 1984;311:874–877. doi: 10.1056/NEJM198410043111402.
    1. Sport-England (2006) Understanding participation in sport: what determines sports participation among recently retired people? . Accessed 29 Sept 2014
    1. Steib S, Schoene D, Pfeifer K. Dose-response relationship of resistance training in older adults: a meta-analysis. Med Sci Sports Exerc. 2010;42:902–914. doi: 10.1249/MSS.0b013e3181c34465.
    1. Stenholm S, Westerlund H, Head J, Hyde M, Kawachi I, Pentti J, Kivimaki M, Vahtera J. Comorbidity and functional trajectories from midlife to old age: the health and retirement study. J Gerontol Ser A. 2014
    1. Stenholm S, Westerlund H, Salo P, Hyde M, Pentti J, Head J, Kivimaki M, Vahtera J. Age-related trajectories of physical functioning in work and retirement: the role of sociodemographic factors, lifestyle and disease. J Epidemiol Commun Health. 2014;68:503–509. doi: 10.1136/jech-2013-203555.
    1. Stenroth L, Sillanpaa E, McPhee JS, Narici MV, Gapeyeva H, Paasuke M, Barnouin Y, Hogrel JY, Butler-Browne G, Bijlsma A, Meskers CG, Maier AB, Finni T, Sipila S. Plantarflexor muscle-tendon properties are associated with mobility in healthy older adults. J Gerontol Ser A. 2015
    1. Stessman J, Hammerman-Rozenberg R, Cohen A, Ein-Mor E, Jacobs JM. Physical activity, function, and longevity among the very old. Arch Intern Med. 2009;169:1476–1483. doi: 10.1001/archinternmed.2009.248.
    1. Stewart KJ, Bacher AC, Turner K, Lim JG, Hees PS, Shapiro EP, Tayback M, Ouyang P. Exercise and risk factors associated with metabolic syndrome in older adults. Am J Prev Med. 2005;28:9–18. doi: 10.1016/j.amepre.2004.09.006.
    1. Sun Q, Townsend MK, Okereke OI, Franco OH, Hu FB, Grodstein F. Physical activity at midlife in relation to successful survival in women at age 70 years or older. Arch Intern Med. 2010;170:194–201. doi: 10.1001/archinternmed.2009.503.
    1. Swain DP, Franklin BA. Comparison of cardioprotective benefits of vigorous versus moderate intensity aerobic exercise. Am J Cardiol. 2006;97:141–147. doi: 10.1016/j.amjcard.2005.07.130.
    1. Syddall H, Roberts HC, Evandrou M, Cooper C, Bergman H, Aihie Sayer A. Prevalence and correlates of frailty among community-dwelling older men and women: findings from the Hertfordshire Cohort Study. Age Ageing. 2010;39:197–203. doi: 10.1093/ageing/afp204.
    1. Tak E, Kuiper R, Chorus A, Hopman-Rock M. Prevention of onset and progression of basic ADL disability by physical activity in community dwelling older adults: a meta-analysis. Ageing Res Rev. 2013;12:329–338. doi: 10.1016/j.arr.2012.10.001.
    1. Trappe S, Hayes E, Galpin A, Kaminsky L, Jemiolo B, Fink W, Trappe T, Jansson A, Gustafsson T, Tesch P. New records in aerobic power among octogenarian lifelong endurance athletes. J Appl Physiol. 2013;114:3–10. doi: 10.1152/japplphysiol.01107.2012.
    1. van Stralen MM, Lechner L, Mudde AN, de Vries H, Bolman C. Determinants of awareness, initiation and maintenance of physical activity among the over-fifties: a Delphi study. Health Educ Res. 2010;25:233–247. doi: 10.1093/her/cyn045.
    1. Wahrendorf M, Reinhardt JD, Siegrist J. Relationships of disability with age among adults aged 50 to 85: evidence from the United States, England and continental Europe. PLoS ONE. 2013;8:e71893. doi: 10.1371/journal.pone.0071893.
    1. Wang BW, Ramey DR, Schettler JD, Hubert HB, Fries JF. Postponed development of disability in elderly runners: a 13-year longitudinal study. Arch Intern Med. 2002;162:2285–2294. doi: 10.1001/archinte.162.20.2285.
    1. Wannamethee SG, Ebrahim S, Papacosta O, Shaper AG. From a postal questionnaire of older men, healthy lifestyle factors reduced the onset of and may have increased recovery from mobility limitation. J Clin Epidemiol. 2005;58:831–840. doi: 10.1016/j.jclinepi.2005.01.007.
    1. Weening-Dijksterhuis E, de Greef MH, Scherder EJ, Slaets JP, van der Schans CP. Frail institutionalized older persons: a comprehensive review on physical exercise, physical fitness, activities of daily living, and quality-of-life. Am J Phys Med Rehabil. 2011;90:156–168. doi: 10.1097/PHM.0b013e3181f703ef.
    1. WHO (2010) Global recommendations on physical activity for health World Health Organisation.
    1. Wilks DC, Winwood K, Gilliver SF, Kwiet A, Chatfield M, Michaelis I, Sun LW, Ferretti JL, Sargeant AJ, Felsenberg D, Rittweger J. Bone mass and geometry of the tibia and the radius of master sprinters, middle and long distance runners, race-walkers and sedentary control participants: a pQCT study. Bone. 2009;45:91–97. doi: 10.1016/j.bone.2009.03.660.
    1. Yao X, Hamilton RG, Weng NP, Xue QL, Bream JH, Li H, Tian J, Yeh SH, Resnick B, Xu X, Walston J, Fried LP, Leng SX. Frailty is associated with impairment of vaccine-induced antibody response and increase in post-vaccination influenza infection in community-dwelling older adults. Vaccine. 2011;29:5015–5021. doi: 10.1016/j.vaccine.2011.04.077.

Source: PubMed

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