Clinical study to monitor dentinal hypersensitivity with episodic use of a desensitising dentifrice

Stephen Mason, Rose Kingston, Lucy Shneyer, Máiréad Harding, Stephen Mason, Rose Kingston, Lucy Shneyer, Máiréad Harding

Abstract

Objectives/aims: To evaluate continuous and episodic twice-daily usage regimens of a desensitising dentifrice containing 5% calcium sodium phosphosilicate (CSPS).

Materials and methods: In this exploratory, single-centre, randomised, examiner-blind study, subjects with dentinal hypersensitivity were randomised to continuous (24 weeks) use of a 5% CSPS-containing dentifrice or episodic use of the dentifrice comprising two 8-week treatment periods separated by 8 weeks' use of a standard fluoride dentifrice. Sensitivity was assessed by tactile threshold (Yeaple probe) and evaporative (air) sensitivity (Schiff sensitivity score). Other measures included labelled magnitude scales to assess subjects' responses to the evaporative stimulus, the Dentine Hypersensitivity Experience Questionnaire and a tooth sensitivity question.

Results: Seventy-six subjects were randomised to continuous (n=38) or episodic (n=38) use. Small but statistically significant improvements from baseline in Schiff sensitivity scores were observed at weeks 8, 16 and 24 with both regimens (all P<0.05). Increases from baseline in tactile threshold were not statistically significant. No significant between-regimen difference was observed for any endpoint. No treatment-related adverse events were reported.

Discussion: Dentifrice containing 5% CSPS improved dentinal hypersensitivity with both episodic and continuous twice-daily usage regimens over 24 weeks and was well tolerated.

Conclusion: No performance differences were observed between the two usage regimens.

Conflict of interest statement

SM is an employee of GSK Consumer Healthcare; RK and MH are employed by Oral Health Services Research Centre, which has received funding from GSK Consumer Healthcare; LS is a consultant who received funding from GSK Consumer Healthcare.

Figures

Figure 1
Figure 1
Subject disposition. CSPS, calcium sodium phosphosilicate; ITT, intent-to-treat; PP, per protocol.
Figure 2
Figure 2
Mean (±s.e.) Schiff sensitivity scores during continuous and episodic use of a desensitising dentifrice containing 5% calcium sodium phosphosilicate (intent-to-treat population). Data have been offset for clarity.
Figure 3
Figure 3
Mean (±s.e.) tactile threshold during continuous and episodic use of a desensitising dentifrice containing 5% calcium sodium phosphosilicate (intent-to-treat population). Tactile-threshold range 0–80 g. Data have been offset for clarity.

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Source: PubMed

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