Single-dose lopinavir-ritonavir acutely inhibits insulin-mediated glucose disposal in healthy volunteers
Grace A Lee, Joan C Lo, Francesca Aweeka, Jean-Marc Schwarz, Kathleen Mulligan, Morris Schambelan, Carl Grunfeld, Grace A Lee, Joan C Lo, Francesca Aweeka, Jean-Marc Schwarz, Kathleen Mulligan, Morris Schambelan, Carl Grunfeld
Abstract
Previously, we found that 4 weeks of treatment with lopinavir-ritonavir did not decrease insulin sensitivity but did increase adiponectin levels. In the present study, a single dose of lopinavir-ritonavir decreases insulin sensitivity but does not alter adiponectin levels. Insulin resistance from protease inhibitors may decrease with prolonged use; an increase in adiponectin levels may mediate this effect.
Conflict of interest statement
Potential conflicts of interest. All authors: no conflicts.
Source: PubMed