Cytosponge-TFF3 Testing can Detect Precancerous Mucosal Changes of the Stomach
Andreas V Hadjinicolaou, Alexander A Azizi, Maria O'Donovan, Irene Debiram, Rebecca C Fitzgerald, Massimiliano Di Pietro, Andreas V Hadjinicolaou, Alexander A Azizi, Maria O'Donovan, Irene Debiram, Rebecca C Fitzgerald, Massimiliano Di Pietro
Abstract
Gastric intestinal metaplasia (GIM) and gastric atrophy (GA) are associated with increased risk of gastric cancer and are indications for endoscopic surveillance when affecting the proximal stomach.1 Endoscopic screening is not cost-effective in areas with low-moderate incidence of gastric cancer2; noninvasive methods to detect GIM/GA are currently lacking.3.
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Figures
Distribution of biopsy findings in TFF3+ and TFF3- groups. Individual histologic findings are represented in the 2 groups with different color coding. The proportion of positive findings (GA, GIM, and cardia IM) does not add up to 100% because they can be diagnosed within the same patient.
References
- Banks M., et al. Gut. 2019;68:1545–1575.
- Liou J.M., et al. Gut. 2020;69:2093–2112.
- Huang Y.K., et al. PLoS One. 2015;10
- Kadri S.R., et al. BMJ. 2010;341:c4372.
- Fitzgerald R.C., et al. Lancet. 2020;396:333–344.
- Pimentel-Nunes P., et al. Endoscopy. 2016;48:723–730.
- Derakhshan M.H., et al. Am J Gastroenterol. 2016;111:228–239.
- Hirota W.K., et al. Gastroenterology. 1999;116:277–285.
Source: PubMed