A systematic review of experimental and clinical acupuncture in chemotherapy-induced peripheral neuropathy

Giovanna Franconi, Luigi Manni, Sven Schröder, Paolo Marchetti, Nicola Robinson, Giovanna Franconi, Luigi Manni, Sven Schröder, Paolo Marchetti, Nicola Robinson

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect that can be very disabling and can limit or delay the dose of chemotherapy that can be administered. Acupuncture may be effective for treating peripheral neuropathy. The aim of this study was to review the available literature on the use of acupuncture for CIPN. The systematic literature search was performed using MEDLINE, Google Scholar, Cochrane Database, CINHAL, and ISI Proceedings. Hand searching was conducted, and consensus was reached on all extracted data. Only papers in the English language were included, irrespective of study design. From 3989 retrieved papers, 8 relevant papers were identified. One was an experimental study which showed that electroacupuncture suppressed CIPN pain in rats. In addition, there were 7 very heterogeneous clinical studies, 1 controlled randomised study using auricular acupuncture, 2 randomized controlled studies using somatic acupuncture, and 3 case series/case reports which suggested a positive effect of acupuncture in CIPN. Conclusions. Only one controlled randomised study demonstrated that acupuncture may be beneficial for CIPN. All the clinical studies reviewed had important methodological limitations. Further studies with robust methodology are needed to demonstrate the role of acupuncture for treating CIPN resulting from cancer treatment.

Figures

Figure 1
Figure 1
Possible targets of acupuncture treatment in CIPN. On the left side are the nervous system areas which are activated by acupuncture; on the right side are some possible beneficial effects of acupuncture in CIPN patients. CIPN = chemotherapy-induced peripheral neuropathy; GABA = gamma amino butyric acid; NGF = nerve growth factor.

References

    1. Windebank AJ, Grisold W. Chemotherapy-induced neuropathy. Journal of the Peripheral Nervous System. 2008;13(1):27–46.
    1. Pachman DR, Barton DL, Watson JC, Loprinzi CL. Chemotherapy-induced peripheral neuropathy: prevention and treatment. Clinical Pharmacology and Therapeutics. 2011;90(3):377–387.
    1. Wolf S, Barton D, Kottschade L, Grothey A, Loprinzi C. Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies. European Journal of Cancer. 2008;44(11):1507–1515.
    1. Podratz JL, Knight AM, Ta LE, et al. Cisplatin induced Mitochondrial DNA damage in dorsal root ganglion neurons. Neurobiology of Disease. 2011;41(3):661–668.
    1. Kim SK, Min BI, Kim JH, et al. Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats. European Journal of Pharmacology. 2005;523(1–3):64–66.
    1. Kim JH, Min BI, Na HS, Park DS. Relieving effects of electroacupuncture on mechanical allodynia in neuropathic pain model of inferior caudal trunk injury in rat: mediation by spinal opioid receptors. Brain Research. 2004;998(2):230–236.
    1. Lau WK, Chan WK, Zhang JL, Yung KKL, Zhang HQ. Electroacupuncture inhibits cyclooxygenase-2 up-regulation in rat spinal cord after spinal nerve ligation. Neuroscience. 2008;155(2):463–468.
    1. Somers DL, Clemente FR. Contralateral high or a combination of high- and low-frequency transcutaneous electrical nerve stimulation reduces mechanical allodynia and alters dorsal horn neurotransmitter content in neuropathic rats. Journal of Pain. 2009;10(2):221–229.
    1. Ko J, Na DS, Lee YH, et al. cDNA microarray analysis of the differential gene expression in the neuropathic pain and electroacupuncture treatment models. Journal of Biochemistry and Molecular Biology. 2002;35(4):420–427.
    1. Molassiotis A, Fernandez-Ortega P, Pud D, et al. Use of complementary and alternative medicine in cancer patients: a european survey. Annals of Oncology. 2005;16(4):655–663.
    1. Ezzo JM, Richardson MA, Vickers A, et al. Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting. Cochrane Database of Systematic Reviews. 2006;(2)CD002285
    1. Johnstone PAS, Peng YP, May BC, Inouye WS, Niemtzow RC. Acupuncture for pilocarpine-resistant xerostomia following radiotherapy for head and neck malignancies. International Journal of Radiation Oncology Biology Physics. 2001;50(2):353–357.
    1. Johnstone PAS, Niemtzow RC, Riffenburgh RH. Acupuncture for xerostomia: clinical update. Cancer. 2002;94(4):1151–1156.
    1. Vickers AJ, Straus DJ, Fearon B, Cassileth BR. Acupuncture for postchemotherapy fatigue: a phase II study. Journal of Clinical Oncology. 2004;22(9):1731–1735.
    1. Dean-Clower E, Doherty-Gilman AM, Keshaviah A, et al. Acupuncture as palliative therapy for physical symptoms and quality of life for advanced cancer patients. Integrative Cancer Therapies. 2010;9(2):158–167.
    1. Abuaisha BB, Costanzi JB, Boulton AJM. Acupuncture for the treatment of chronic painful peripheral diabetic neuropathy: a long-term study. Diabetes Research and Clinical Practice. 1998;39(2):115–121.
    1. Zhang C, Ma Y, Yan Y. Clinical effects of acupuncture for diabetic peripheral neuropathy. Journal of Traditional Chinese Medicine. 2010;30(1):13–14.
    1. Beal MW, Nield-Anderson L. Acupuncture for symptom relief in HIV-positive adults: lessons learned from a pilot study. Alternative Therapies in Health and Medicine. 2000;6(5):33–42.
    1. Wu B. Recent development of studies on traditional Chinese medicine in prophylaxis and treatment of AIDS. Journal of Traditional Chinese Medicine. 1992;12(1):10–20.
    1. Özsoy M, Ernst E. How effective are complementary therapies for HIV and AIDS? A systematic review. International Journal of STD and AIDS. 1999;10(10):629–635.
    1. Power R, Gore-Felton C, Vosvick M, Israelski DM, Spiegel D. HIV: effectiveness of complementary and alternative medicine. Primary Care. 2002;29(2):361–378.
    1. Head KA. Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Alternative Medicine Review. 2006;11(4):294–329.
    1. Alimi D, Rubino C, Pichard-Léandri E, Fermand-Brulé S, Dubreuil-Lemaire M, Hill C. Analgesic effect of auricular acupuncture for cancer pain: a randomized, blinded, controlled trial. Journal of Clinical Oncology. 2003;21(22):4120–4126.
    1. Wong R, Sagar S. Acupuncture treatment for chemotherapy-induced peripheral neuropathy—a case series. Acupuncture in Medicine. 2006;24(2):87–91.
    1. Xu WR, Hua BJ, Hou W, Bao YJ. Clinical randomized controlled study on acupuncture for treatment of peripheral neuropathy induced by chemotherapeutic drugs. Zhongguo Zhen Jiu. 2010;30(6):457–460.
    1. Bao T, Zhang R, Badros A, Lao L. Acupuncture treatment for bortezomib-induced peripheral neuropathy: a case report. Pain Research and Treatment. 2011;2011:4 pages.920807
    1. Donald GK, Tobin I, Stringer J. Evaluation of acupuncture in the management of chemotherapy-induced peripheral neuropathy. Acupuncture in Medicine. 2011;29(3):230–233.
    1. Schroeder S, Meyer-Hamme G, Epplée S. Acupuncture for chemotherapy-induced peripheral neuropathy (CIPN): a pilot study using neurography. Acupuncture in Medicine. 2012;30(1):4–7.
    1. Tian YP, Zhang Y, Jia YJ. The curative effect of warm acupuncture and moxibustion on peripheral neurotoxicity caused by oxaliplatin. Tianjin Journal of Traditional Chinese Medicine. 2011;3:212–213.
    1. Meng X, Zhang Y, Li A, et al. The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy. Brain Research. 2011;1414:58–65.
    1. Ulett GA, Han J, Han S. Traditional and evidence-based acupuncture: history, mechanisms, and present status. Southern Medical Journal. 1998;91(12):1115–1120.
    1. Cassileth BR, Deng GE, Gomez JE, Johnstone PAS, Kumar N, Vickers AJ. Complementary therapies and integrative oncology in lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition) Chest. 2007;132(3):340–354.
    1. Wu MT, Hsieh JC, Xiong J, et al. Central nervous pathway for acupunture stimulation: localization of processing with functional MR imaging of the brain—preliminary experience. Radiology. 1999;212(1):133–141.
    1. Lund I, Lundeberg T. Are minimal, superficial or sham acupuncture procedures acceptable as inert placebo controls? Acupuncture in Medicine. 2006;24(1):13–15.
    1. Lund I, Näslund J, Lundeberg T. Minimal acupuncture is not a valid placebo control in randomised controlled trials of acupuncture: a physiologist’s perspective. Chinese Medicine. 2009;4(article 1)
    1. Lundeberg T, Lund I, Sing A, Näslund J. Is placebo acupuncture what it is intended to be? Evidence-Based Complementary and Alternative Medicine. 2011;2011:5 pages.932407
    1. Andersson S, Lundeberg T. Acupuncture—from empiricism to science functional background to acupuncture effects in pain and disease. Medical Hypotheses. 1995;45(3):271–281.
    1. Robinson N, Lorenc A, Ding W, Jia J, Bovey M, Wang X. Exploring practice characteristics and research priorities of practitioners of traditional acupuncture in China and the EU—a survey. Journal of Ethnopharmacology. 2012;140(3):604–613.
    1. Cohen AJ, Menter A, Hale L. Acupuncture: role in comprehensive cancer care—a primer for the oncologist and review of the literature. Integrative Cancer Therapies. 2005;4(2):131–143.
    1. Cavaletti G, Marmiroli P. The role of growth factors in the prevention and treatment of chemotherapy-induced peripheral neurotoxicity. Current Drug Safety. 2006;1(1):35–42.
    1. Aloe L, Manni L, Properzi F, de Santis S, Fiore M. Evidence that nerve growth factor promotes the recovery of peripheral neuropathy induced in mice by Cisplatin: behavioral, structural and biochemical analysis. Autonomic Neuroscience. 2000;86(1-2):84–93.
    1. Cavaletti G, Bogliun G, Marzorati L, et al. Early predictors of peripheral neurotoxicity in cisplatin and paclitaxel combination chemotherapy. Annals of Oncology. 2004;15(9):1439–1442.
    1. de Santis S, Pace A, Bove L, et al. Patients treated with antitumor drugs displaying neurological deficits are characterized by a low circulating level of nerve growth factor. Clinical Cancer Research. 2000;6(1):90–95.
    1. Geldof AA. Nerve-growth-factor dependent neurite outgrowth assay; a research model for chemotherapy-induced neuropathy. Journal of Cancer Research and Clinical Oncology. 1995;121(11):657–660.
    1. Levi-Montalcini R. The nerve growth factor 35 years later. Science. 1987;237(4819):1154–1162.
    1. Zhang ZJ, Wang XM, McAlonan GM. Neural acupuncture unit: a new concept for interpreting effects and mechanisms of acupuncture. Evidence-Based Complementary and Alternative Medicine. 2012;2012:23 pages.429412
    1. Aloe L, Manni L. Low-frequency electro-acupuncture reduces the nociceptive response and the pain mediator enhancement induced by nerve growth factor. Neuroscience Letters. 2009;449(3):173–177.
    1. Dong ZQ, Ma F, Xie H, Wang YQ, Wu GC. Changes of expression of glial cell line-derived neurotrophic factor and its receptor in dorsal root ganglions and spinal dorsal horn during electroacupuncture treatment in neuropathic pain rats. Neuroscience Letters. 2005;376(2):143–148.
    1. Liang XB, Luo Y, Liu XY, et al. Electro-acupuncture improves behavior and upregulates GDNF mRNA in MFB transected rats. NeuroReport. 2003;14(8):1177–1181.
    1. Wei G, Huang Y, Wu G, Cao X. Regulation of glial cell line-derived neurotrophic factor expression by electroacupuncture after transient focal cerebral ischemia. Acupuncture and Electro-Therapeutics Research. 2000;25(2):81–90.
    1. Liang XB, Liu XY, Li FQ, et al. Long-term high-frequency electro-acupuncture stimulation prevents neuronal degeneration and up-regulates BDNF mRNA in the substantia nigra and ventral tegmental area following medial forebrain bundle axotomy. Molecular Brain Research. 2002;108(1-2):51–59.
    1. Manni L, Albanesi M, Guaragna M, Barbaro Paparo S, Aloe L. Neurotrophins and acupuncture. Autonomic Neuroscience. 2010;157(1-2):9–17.
    1. Mannerås L, Jonsdottir IH, Holmäng A, Lönn M, Stener-Victorin E. Low-frequency electro-acupuncture and physical exercise improve metabolic disturbances and modulate gene expression in adipose tissue in rats with dihydrotestosterone-induced polycystic ovary syndrome. Endocrinology. 2008;149(7):3559–3568.
    1. Sung HJ, Kim YS, Kim IS, et al. Proteomic analysis of differential protein expression in neuropathic pain and electroacupuncture treatment models. Proteomics. 2004;4(9):2805–2813.
    1. Xing GC, Liu FY, Qu XX, Han JS, Wan Y. Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain. Experimental Neurology. 2007;208(2):323–332.
    1. Fusumada K, Yokoyama T, Miki T, et al. C-Fos expression in the periaqueductal gray is induced by electroacupuncture in the rat, with possible reference to GABAergic neurons. Okajimas Folia Anatomica Japonica. 2007;84(1):1–10.
    1. Silva JRT, Silva ML, Prado WA. Analgesia induced by 2- or 100-Hz electroacupuncture in the rat tail-flick test depends on the activation of different descending pain inhibitory mechanisms. Journal of Pain. 2011;12(1):51–60.
    1. Park JH, Han JB, Kim SK, Go DH, Sun B, Min BI. Spinal GABA receptors mediate the suppressive effect of electroacupuncture on cold allodynia in rats. Brain Research. 2010;1322:24–29.
    1. Manni L, Florenzano F, Aloe L. Electroacupuncture counteracts the development of thermal hyperalgesia and the alteration of nerve growth factor and sensory neuromodulators induced by streptozotocin in adult rats. Diabetologia. 2011;54(7):1900–1908.
    1. Ventura C. CAM and cell fate targeting: molecular and energetic insights into cell growth and differentiation. Evidence-Based Complementary and Alternative Medicine. 2005;2(3):277–283.
    1. Nori SL, Rocco ML, Florenzano F, Ciotti MT, Aloe L, Manni L. Increased nerve growth factor signaling in sensory neurons of early diabetic rats is corrected by electroacupuncture. Evidence-Based Complementary and Alternative Medicine. 2013;2013:15 pages.652735
    1. Huang W, Pach D, Napadow V, et al. Characterizing acupuncture stimuli using brain imaging with fMRI—a systematic review and meta-analysis of the literature. PLoS ONE. 2012;7(4)e32960

Source: PubMed

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