Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome 6 Oliguria (
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome 7 Intraventricular haemorrhage (any grade).
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome 8 Intraventricular haemorrhage (grades III and IV).
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome 9 Periventricular leukomalacia.
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome 10 Retinopathy of prematurity (any stage).
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome 11 Retinopathy of prematurity (stage 3 or 4).
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome 12 Necrotising enterocolitis.
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome 13 Chronic lung disease (at 36 weeks' postmenstrual age).
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome 14 Sepsis.
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome 15 Hospital stay (days).
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome 16 Oliguria (
Analysis 6.17
Comparison 6 High‐dose (oral or…
Analysis 6.17
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.17 Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome 17 Gastrointestinal bleed.
Analysis 6.18
Comparison 6 High‐dose (oral or…
Analysis 6.18
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.18 Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome 18 Platelet count (x 109/L) after treatment.
Analysis 6.19
Comparison 6 High‐dose (oral or…
Analysis 6.19
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.19 Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome 19 Serum creatinine (µmol/L) after treatment.
Analysis 7.1
Comparison 7 Early versus expectant…
Analysis 7.1
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 1 Days on…
Analysis 7.1 Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 1 Days on supplemental oxygen during the first 28 days.
Analysis 7.2
Comparison 7 Early versus expectant…
Analysis 7.2
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 2 Days on…
Analysis 7.2 Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 2 Days on supplemental oxygen.
Analysis 7.3
Comparison 7 Early versus expectant…
Analysis 7.3
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 3 Days on…
Analysis 7.3 Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 3 Days on mechanical ventilation first 28 days.
Analysis 7.4
Comparison 7 Early versus expectant…
Analysis 7.4
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 4 Days on…
Analysis 7.4 Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 4 Days on mechanical ventilation.
Analysis 7.5
Comparison 7 Early versus expectant…
Analysis 7.5
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 5 Chronic lung…
Analysis 7.5 Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 5 Chronic lung disease (at 36 weeks' postmenstrual age (PMA)).
Analysis 7.6
Comparison 7 Early versus expectant…
Analysis 7.6
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 6 Mortality or…
Analysis 7.6 Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 6 Mortality or chronic lung disease (at 36 weeks' PMA).
Analysis 7.7
Comparison 7 Early versus expectant…
Analysis 7.7
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 7 Mortality during…
Analysis 7.7 Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 7 Mortality during hospital stay.
Analysis 7.8
Comparison 7 Early versus expectant…
Analysis 7.8
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 8 Pneumothorax.
Analysis 7.8 Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 8 Pneumothorax.
Analysis 7.9
Comparison 7 Early versus expectant…
Analysis 7.9
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 9 Intraventricular haemorrhage…
Analysis 7.9 Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 9 Intraventricular haemorrhage (grades III and IV).
Analysis 7.10
Comparison 7 Early versus expectant…
Analysis 7.10
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 10 Periventricular leukomalacia.
Analysis 7.10 Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 10 Periventricular leukomalacia.
Analysis 7.11
Comparison 7 Early versus expectant…
Analysis 7.11
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 11 Necrotising enterocolitis…
Analysis 7.11 Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 11 Necrotising enterocolitis (requiring surgery).
Analysis 7.12
Comparison 7 Early versus expectant…
Analysis 7.12
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 12 Intestinal perforation.
Analysis 7.12 Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 12 Intestinal perforation.
Analysis 7.13
Comparison 7 Early versus expectant…
Analysis 7.13
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 13 Sepsis.
Analysis 7.13 Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 13 Sepsis.
Analysis 7.14
Comparison 7 Early versus expectant…
Analysis 7.14
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 14 Retinopathy of…
Analysis 7.14 Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 14 Retinopathy of prematurity (stage 3 or 4).
Analysis 8.1
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.1
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.1 Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome 1 Failure to close a patent ductus arteriosus (PDA).
Analysis 8.2
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.2
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.2 Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome 2 Reopening of PDA.
Analysis 8.3
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.3
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.3 Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome 3 Number of ibuprofen doses.
Analysis 8.4
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.4
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.4 Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome 4 Mortality during hospital stay.
Analysis 8.5
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.5
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.5 Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome 5 Bronchopulmonary dysplasia (supplemental oxygen at 36 weeks' postmenstrual age).
Analysis 8.6
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.6
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.6 Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome 6 Necrotising enterocolitis.
Analysis 8.7
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.7
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.7 Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome 7 Intraventricular haemorrhage (grade II and III).
Analysis 8.8
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.8
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.8 Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome 8 White matter damage.
Analysis 8.9
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.9
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.9 Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome 9 Oliguria (urine output
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.10 Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome 10 Serum/plasma creatinine (µmol/L) after treatment.
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.11 Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome 11 Laser therapy for retinopathy of prematurity.
Analysis 9.1
Comparison 9 Continuous infusion of…
Analysis 9.1
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 1…
Analysis 9.1 Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 1 Failure to close a patent ductus arteriosus (PDA) after 1 course of ibuprofen.
Analysis 9.2
Comparison 9 Continuous infusion of…
Analysis 9.2
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 2…
Analysis 9.2 Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 2 Reopening of PDA.
Analysis 9.3
Comparison 9 Continuous infusion of…
Analysis 9.3
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 3…
Analysis 9.3 Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 3 Need for surgical ligation.
Analysis 9.4
Comparison 9 Continuous infusion of…
Analysis 9.4
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 4…
Analysis 9.4 Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 4 Mortality (in hospital).
Analysis 9.5
Comparison 9 Continuous infusion of…
Analysis 9.5
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 5…
Analysis 9.5 Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 5 Chronic lung disease (at 36 weeks' postmenstrual age).
Analysis 9.6
Comparison 9 Continuous infusion of…
Analysis 9.6
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 6…
Analysis 9.6 Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 6 Retinopathy of prematurity (any stage).
Analysis 9.7
Comparison 9 Continuous infusion of…
Analysis 9.7
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 7…
Analysis 9.7 Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 7 Retinopathy of prematurity (stage 3 or 4).
Analysis 9.8
Comparison 9 Continuous infusion of…
Analysis 9.8
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 8…
Analysis 9.8 Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 8 Intraventricular haemorrhage (any grade).
Analysis 9.9
Comparison 9 Continuous infusion of…
Analysis 9.9
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 9…
Analysis 9.9 Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 9 Intraventricular haemorrhage (grade III and IV).
Analysis 9.10
Comparison 9 Continuous infusion of…
Analysis 9.10
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 10…
Analysis 9.10 Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 10 Periventricular leukomalacia (cystic).
Analysis 9.11
Comparison 9 Continuous infusion of…
Analysis 9.11
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 11…
Analysis 9.11 Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 11 Necrotising enterocolitis.
Analysis 9.12
Comparison 9 Continuous infusion of…
Analysis 9.12
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 12…
Analysis 9.12 Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 12 Isolated intestinal perforation.
Analysis 9.13
Comparison 9 Continuous infusion of…
Analysis 9.13
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 13…
Analysis 9.13 Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 13 Oliguria (urine output ≤ 1 mL/kg/hour).
Analysis 9.14
Comparison 9 Continuous infusion of…
Analysis 9.14
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 14…
Analysis 9.14 Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 14 Serum/plasma creatinine after treatment (µmol/L).
Analysis 9.15
Comparison 9 Continuous infusion of…
Analysis 9.15
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 15…
Analysis 9.15 Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 15 Gastrointestinal haemorrhage.
Analysis 10.1
Comparison 10 Rectal ibuprofen versus…
Analysis 10.1
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 1 Failure to close a…
Analysis 10.1 Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 1 Failure to close a PDA after 3 doses.
Analysis 10.2
Comparison 10 Rectal ibuprofen versus…
Analysis 10.2
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 2 Need for surgical ligation.
Analysis 10.2 Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 2 Need for surgical ligation.
Analysis 10.3
Comparison 10 Rectal ibuprofen versus…
Analysis 10.3
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 3 Plasma creatinine (µmol/L.
Analysis 10.3 Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 3 Plasma creatinine (µmol/L.
Analysis 10.4
Comparison 10 Rectal ibuprofen versus…
Analysis 10.4
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 4 Plasma bilirubin (µmol/L) after…
Analysis 10.4 Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 4 Plasma bilirubin (µmol/L) after treatment.
Analysis 10.5
Comparison 10 Rectal ibuprofen versus…
Analysis 10.5
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 5 Urine output (mL/kg/hr) after…
Analysis 10.5 Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 5 Urine output (mL/kg/hr) after treatment.
All figures (166)