Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants
Arne Ohlsson, Rajneesh Walia, Sachin S Shah, Arne Ohlsson, Rajneesh Walia, Sachin S Shah
Abstract
Background: Indomethacin is used as standard therapy to close a patent ductus arteriosus (PDA) but is associated with reduced blood flow to several organs. Ibuprofen, another cyclo-oxygenase inhibitor, may be as effective as indomethacin with fewer adverse effects.
Objectives: To determine the effectiveness and safety of ibuprofen compared with indomethacin, other cyclo-oxygenase inhibitor(s), placebo, or no intervention for closing a patent ductus arteriosus in preterm, low-birth-weight, or preterm and low-birth-weight infants.
Search methods: We used the standard search strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL 2017, Issue 10), MEDLINE via PubMed (1966 to 30 November 2017), Embase (1980 to 30 November 2017), and CINAHL (1982 to 30 November 2017). We searched clinical trials databases, conference proceedings, and the reference lists of retrieved articles for randomised controlled trials and quasi-randomised trials.
Selection criteria: Randomised or quasi-randomised controlled trials of ibuprofen for the treatment of a PDA in preterm, low birth weight, or both preterm and low-birth-weight newborn infants.
Data collection and analysis: Data collection and analysis conformed to the methods of the Cochrane Neonatal Review Group. We used the GRADE approach to assess the quality of evidence.
Main results: We included 39 studies enrolling 2843 infants.Ibuprofen (IV) versus placebo: IV Ibuprofen (3 doses) reduced the failure to close a PDA compared with placebo (typical relative risk (RR); 0.62 (95% CI 0.44 to 0.86); typical risk difference (RD); -0.18 (95% CI -0.30 to -0.06); NNTB 6 (95% CI 3 to 17); I2 = 65% for RR and I2 = 0% for RD; 2 studies, 206 infants; moderate-quality the evidence). One study reported decreased failure to close a PDA after single or three doses of oral ibuprofen compared with placebo (64 infants; RR 0.26, 95% CI 0.11 to 0.62; RD -0.44, 95% CI -0.65 to -0.23; NNTB 2, 95% CI 2 to 4; I2 test not applicable).Ibuprofen (IV or oral) compared with indomethacin (IV or oral): Twenty-four studies (1590 infants) comparing ibuprofen (IV or oral) with indomethacin (IV or oral) found no significant differences in failure rates for PDA closure (typical RR 1.07, 95% CI 0.92 to 1.24; typical RD 0.02, 95% CI -0.02 to 0.06; I2 = 0% for both RR and RD; moderate-quality evidence). A reduction in NEC (necrotising enterocolitis) was noted in the ibuprofen (IV or oral) group (18 studies, 1292 infants; typical RR 0.68, 95% CI 0.49 to 0.94; typical RD -0.04, 95% CI -0.07 to -0.01; NNTB 25, 95% CI 14 to 100; I2 = 0% for both RR and RD; moderate-quality evidence). There was a statistically significant reduction in the proportion of infants with oliguria in the ibuprofen group (6 studies, 576 infants; typical RR 0.28, 95% CI 0.14 to 0.54; typical RD -0.09, 95% CI -0.14 to -0.05; NNTB 11, 95% CI 7 to 20; I2 = 24% for RR and I2 = 69% for RD; moderate-quality evidence). The serum/plasma creatinine levels 72 hours after initiation of treatment were statistically significantly lower in the ibuprofen group (11 studies, 918 infants; MD -8.12 µmol/L, 95% CI -10.81 to -5.43). For this comparison, there was high between-study heterogeneity (I2 = 83%) and low-quality evidence.Ibuprofen (oral) compared with indomethacin (IV or oral): Eight studies (272 infants) reported on failure rates for PDA closure in a subgroup of the above studies comparing oral ibuprofen with indomethacin (IV or oral). There was no significant difference between the groups (typical RR 0.96, 95% CI 0.73 to 1.27; typical RD -0.01, 95% CI -0.12 to 0.09; I2 = 0% for both RR and RD). The risk of NEC was reduced with oral ibuprofen compared with indomethacin (IV or oral) (7 studies, 249 infants; typical RR 0.41, 95% CI 0.23 to 0.73; typical RD -0.13, 95% CI -0.22 to -0.05; NNTB 8, 95% CI 5 to 20; I2 = 0% for both RR and RD). There was low-quality evidence for these two outcomes. There was a decreased risk of failure to close a PDA with oral ibuprofen compared with IV ibuprofen (5 studies, 406 infants; typical RR 0.38, 95% CI 0.26 to 0.56; typical RD -0.22, 95% CI -0.31 to -0.14; NNTB 5, 95% CI 3 to 7; moderate-quality evidence). There was a decreased risk of failure to close a PDA with high-dose versus standard-dose of IV ibuprofen (3 studies 190 infants; typical RR 0.37, 95% CI 0.22 to 0.61; typical RD - 0.26, 95% CI -0.38 to -0.15; NNTB 4, 95% CI 3 to 7); I2 = 4% for RR and 0% for RD); moderate-quality evidence).Early versus expectant administration of IV ibuprofen, echocardiographically-guided IV ibuprofen treatment versus standard IV ibuprofen treatment, continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, and rectal ibuprofen versus oral ibuprofen were studied in too few trials to allow for precise estimates of any clinical outcomes.
Authors' conclusions: Ibuprofen is as effective as indomethacin in closing a PDA. Ibuprofen reduces the risk of NEC and transient renal insufficiency. Therefore, of these two drugs, ibuprofen appears to be the drug of choice. The effectiveness of ibuprofen versus paracetamol is assessed in a separate review. Oro-gastric administration of ibuprofen appears as effective as IV administration. To make further recommendations, studies are needed to assess the effectiveness of high-dose versus standard-dose ibuprofen, early versus expectant administration of ibuprofen, echocardiographically-guided versus standard IV ibuprofen, and continuous infusion versus intermittent boluses of ibuprofen. Studies are lacking evaluating the effect of ibuprofen on longer-term outcomes in infants with PDA.
Conflict of interest statement
Arne Ohlsson ‐ none known.
Rajneesh Walia ‐ none known.
Sachin Shah ‐ none known.
Figures
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![Analysis 1.1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-001-01.jpg)
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![Analysis 1.9](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-001-09.jpg)
![Analysis 1.10](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-001-10.jpg)
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![Analysis 1.12](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-001-12.jpg)
![Analysis 1.13](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-001-13.jpg)
![Analysis 1.14](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-001-14.jpg)
![Analysis 1.15](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-001-15.jpg)
Analysis 1.16
Comparison 1 Intravenous ibuprofen versus…
Analysis 1.16
Comparison 1 Intravenous ibuprofen versus placebo, Outcome 16 Creatinine (µmol/L) after treatment.
Analysis 1.17
Comparison 1 Intravenous ibuprofen versus…
Analysis 1.17
Comparison 1 Intravenous ibuprofen versus placebo, Outcome 17 Blood urea nitrogen (µmol/L).
Analysis 1.18
Comparison 1 Intravenous ibuprofen versus…
Analysis 1.18
Comparison 1 Intravenous ibuprofen versus placebo, Outcome 18 Mortality.
Analysis 2.1
Comparison 2 Oral ibuprofen versus…
Analysis 2.1
Comparison 2 Oral ibuprofen versus placebo, Outcome 1 Failure to close a patent…
Analysis 3.1
Comparison 3 Intravenous or oral…
Analysis 3.1
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 1…
Analysis 3.2
Comparison 3 Intravenous or oral…
Analysis 3.2
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 2…
Analysis 3.3
Comparison 3 Intravenous or oral…
Analysis 3.3
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 3…
Analysis 3.4
Comparison 3 Intravenous or oral…
Analysis 3.4
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 4…
Analysis 3.5
Comparison 3 Intravenous or oral…
Analysis 3.5
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 5…
Analysis 3.6
Comparison 3 Intravenous or oral…
Analysis 3.6
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 6…
Analysis 3.7
Comparison 3 Intravenous or oral…
Analysis 3.7
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 7…
Analysis 3.8
Comparison 3 Intravenous or oral…
Analysis 3.8
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 8…
Analysis 3.9
Comparison 3 Intravenous or oral…
Analysis 3.9
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 9…
Analysis 3.10
Comparison 3 Intravenous or oral…
Analysis 3.10
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 10…
Analysis 3.11
Comparison 3 Intravenous or oral…
Analysis 3.11
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 11…
Analysis 3.12
Comparison 3 Intravenous or oral…
Analysis 3.12
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 12…
Analysis 3.13
Comparison 3 Intravenous or oral…
Analysis 3.13
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 13…
Analysis 3.14
Comparison 3 Intravenous or oral…
Analysis 3.14
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 14…
Analysis 3.15
Comparison 3 Intravenous or oral…
Analysis 3.15
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 15…
Analysis 3.16
Comparison 3 Intravenous or oral…
Analysis 3.16
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 16…
Analysis 3.17
Comparison 3 Intravenous or oral…
Analysis 3.17
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 17…
Analysis 3.18
Comparison 3 Intravenous or oral…
Analysis 3.18
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 18…
Analysis 3.19
Comparison 3 Intravenous or oral…
Analysis 3.19
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 19…
Analysis 3.20
Comparison 3 Intravenous or oral…
Analysis 3.20
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 20…
Analysis 3.21
Comparison 3 Intravenous or oral…
Analysis 3.21
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 21…
Analysis 3.22
Comparison 3 Intravenous or oral…
Analysis 3.22
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 22…
Analysis 3.23
Comparison 3 Intravenous or oral…
Analysis 3.23
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 23…
Analysis 3.24
Comparison 3 Intravenous or oral…
Analysis 3.24
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 24…
Analysis 3.25
Comparison 3 Intravenous or oral…
Analysis 3.25
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 25…
Analysis 3.26
Comparison 3 Intravenous or oral…
Analysis 3.26
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 26…
Analysis 3.27
Comparison 3 Intravenous or oral…
Analysis 3.27
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 27…
Analysis 3.28
Comparison 3 Intravenous or oral…
Analysis 3.28
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 28…
Analysis 3.29
Comparison 3 Intravenous or oral…
Analysis 3.29
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 29…
Analysis 3.30
Comparison 3 Intravenous or oral…
Analysis 3.30
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 30…
Analysis 3.31
Comparison 3 Intravenous or oral…
Analysis 3.31
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 31…
Analysis 4.1
Comparison 4 Oral ibuprofen versus…
Analysis 4.1
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 1 Failure…
Analysis 4.2
Comparison 4 Oral ibuprofen versus…
Analysis 4.2
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 2 All‐cause…
Analysis 4.3
Comparison 4 Oral ibuprofen versus…
Analysis 4.3
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 3 Neonatal…
Analysis 4.4
Comparison 4 Oral ibuprofen versus…
Analysis 4.4
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 4 Reopening…
Analysis 4.5
Comparison 4 Oral ibuprofen versus…
Analysis 4.5
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 5 Need…
Analysis 4.6
Comparison 4 Oral ibuprofen versus…
Analysis 4.6
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 6 Pulmonary…
Analysis 4.7
Comparison 4 Oral ibuprofen versus…
Analysis 4.7
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 7 Pulmonary…
Analysis 4.8
Comparison 4 Oral ibuprofen versus…
Analysis 4.8
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 8 Chronic…
Analysis 4.9
Comparison 4 Oral ibuprofen versus…
Analysis 4.9
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 9 Chronic…
Analysis 4.10
Comparison 4 Oral ibuprofen versus…
Analysis 4.10
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 10 Intraventricular…
Analysis 4.11
Comparison 4 Oral ibuprofen versus…
Analysis 4.11
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 11 Intraventricular…
Analysis 4.12
Comparison 4 Oral ibuprofen versus…
Analysis 4.12
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 12 Periventricular…
Analysis 4.13
Comparison 4 Oral ibuprofen versus…
Analysis 4.13
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 13 Necrotising…
Analysis 4.14
Comparison 4 Oral ibuprofen versus…
Analysis 4.14
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 14 Intestinal…
Analysis 4.15
Comparison 4 Oral ibuprofen versus…
Analysis 4.15
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 15 Gastrointestinal…
Analysis 4.16
Comparison 4 Oral ibuprofen versus…
Analysis 4.16
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 16 Retinopathy…
Analysis 4.17
Comparison 4 Oral ibuprofen versus…
Analysis 4.17
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 17 Sepsis.
Analysis 4.18
Comparison 4 Oral ibuprofen versus…
Analysis 4.18
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 18 Oliguria…
Analysis 4.19
Comparison 4 Oral ibuprofen versus…
Analysis 4.19
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 19 Serum/plasma…
Analysis 4.20
Comparison 4 Oral ibuprofen versus…
Analysis 4.20
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 20 Duration…
Analysis 5.1
Comparison 5 Oral ibuprofen versus…
Analysis 5.1
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 1 Failure to close…
Analysis 5.2
Comparison 5 Oral ibuprofen versus…
Analysis 5.2
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 2 Mortality (during first…
Analysis 5.3
Comparison 5 Oral ibuprofen versus…
Analysis 5.3
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 3 Mortality (during hospital…
Analysis 5.4
Comparison 5 Oral ibuprofen versus…
Analysis 5.4
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 4 Mean plasma cystatin‐C…
Analysis 5.5
Comparison 5 Oral ibuprofen versus…
Analysis 5.5
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 5 Need for surgical…
Analysis 5.6
Comparison 5 Oral ibuprofen versus…
Analysis 5.6
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 6 Duration of ventilatory…
Analysis 5.7
Comparison 5 Oral ibuprofen versus…
Analysis 5.7
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 7 Duration of hospitalisation…
Analysis 5.8
Comparison 5 Oral ibuprofen versus…
Analysis 5.8
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 8 Pneumothorax.
Analysis 5.9
Comparison 5 Oral ibuprofen versus…
Analysis 5.9
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 9 Pulmonary haemorrhage.
Analysis 5.10
Comparison 5 Oral ibuprofen versus…
Analysis 5.10
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 10 Pulmonary hypertension.
Analysis 5.11
Comparison 5 Oral ibuprofen versus…
Analysis 5.11
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 11 Chronic lung disease…
Analysis 5.12
Comparison 5 Oral ibuprofen versus…
Analysis 5.12
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 12 Intraventricular haemorrhage (any…
Analysis 5.13
Comparison 5 Oral ibuprofen versus…
Analysis 5.13
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 13 Periventricular leukomalacia.
Analysis 5.14
Comparison 5 Oral ibuprofen versus…
Analysis 5.14
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 14 Necrotising enterocolitis (any…
Analysis 5.15
Comparison 5 Oral ibuprofen versus…
Analysis 5.15
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 15 Intestinal perforation.
Analysis 5.16
Comparison 5 Oral ibuprofen versus…
Analysis 5.16
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 16 Gastrointestinal bleed.
Analysis 5.17
Comparison 5 Oral ibuprofen versus…
Analysis 5.17
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 17 Sepsis.
Analysis 5.18
Comparison 5 Oral ibuprofen versus…
Analysis 5.18
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 18 Retinopathy of prematurity…
Analysis 5.19
Comparison 5 Oral ibuprofen versus…
Analysis 5.19
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 19 Serum/plasma creatinine levels…
Analysis 5.20
Comparison 5 Oral ibuprofen versus…
Analysis 5.20
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 20 Oliguria (Urine output…
Analysis 5.21
Comparison 5 Oral ibuprofen versus…
Analysis 5.21
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 21 Mental Developmental Index…
Analysis 5.22
Comparison 5 Oral ibuprofen versus…
Analysis 5.22
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 22 Psychomotor Developmental Index…
Analysis 5.23
Comparison 5 Oral ibuprofen versus…
Analysis 5.23
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 23 Moderate/severe cerebral palsy…
Analysis 5.24
Comparison 5 Oral ibuprofen versus…
Analysis 5.24
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 24 Blindness at 18‐24…
Analysis 5.25
Comparison 5 Oral ibuprofen versus…
Analysis 5.25
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 25 Deafness at 18‐24…
Analysis 6.1
Comparison 6 High‐dose (oral or…
Analysis 6.1
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.2
Comparison 6 High‐dose (oral or…
Analysis 6.2
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.3
Comparison 6 High‐dose (oral or…
Analysis 6.3
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.4
Comparison 6 High‐dose (oral or…
Analysis 6.4
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.5
Comparison 6 High‐dose (oral or…
Analysis 6.5
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.6
Comparison 6 High‐dose (oral or…
Analysis 6.6
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.7
Comparison 6 High‐dose (oral or…
Analysis 6.7
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.8
Comparison 6 High‐dose (oral or…
Analysis 6.8
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.9
Comparison 6 High‐dose (oral or…
Analysis 6.9
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.10
Comparison 6 High‐dose (oral or…
Analysis 6.10
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.11
Comparison 6 High‐dose (oral or…
Analysis 6.11
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.12
Comparison 6 High‐dose (oral or…
Analysis 6.12
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.13
Comparison 6 High‐dose (oral or…
Analysis 6.13
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.14
Comparison 6 High‐dose (oral or…
Analysis 6.14
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.15
Comparison 6 High‐dose (oral or…
Analysis 6.15
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.16
Comparison 6 High‐dose (oral or…
Analysis 6.16
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.17
Comparison 6 High‐dose (oral or…
Analysis 6.17
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.18
Comparison 6 High‐dose (oral or…
Analysis 6.18
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.19
Comparison 6 High‐dose (oral or…
Analysis 6.19
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 7.1
Comparison 7 Early versus expectant…
Analysis 7.1
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 1 Days on…
Analysis 7.2
Comparison 7 Early versus expectant…
Analysis 7.2
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 2 Days on…
Analysis 7.3
Comparison 7 Early versus expectant…
Analysis 7.3
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 3 Days on…
Analysis 7.4
Comparison 7 Early versus expectant…
Analysis 7.4
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 4 Days on…
Analysis 7.5
Comparison 7 Early versus expectant…
Analysis 7.5
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 5 Chronic lung…
Analysis 7.6
Comparison 7 Early versus expectant…
Analysis 7.6
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 6 Mortality or…
Analysis 7.7
Comparison 7 Early versus expectant…
Analysis 7.7
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 7 Mortality during…
Analysis 7.8
Comparison 7 Early versus expectant…
Analysis 7.8
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 8 Pneumothorax.
Analysis 7.9
Comparison 7 Early versus expectant…
Analysis 7.9
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 9 Intraventricular haemorrhage…
Analysis 7.10
Comparison 7 Early versus expectant…
Analysis 7.10
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 10 Periventricular leukomalacia.
Analysis 7.11
Comparison 7 Early versus expectant…
Analysis 7.11
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 11 Necrotising enterocolitis…
Analysis 7.12
Comparison 7 Early versus expectant…
Analysis 7.12
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 12 Intestinal perforation.
Analysis 7.13
Comparison 7 Early versus expectant…
Analysis 7.13
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 13 Sepsis.
Analysis 7.14
Comparison 7 Early versus expectant…
Analysis 7.14
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 14 Retinopathy of…
Analysis 8.1
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.1
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.2
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.2
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.3
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.3
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.4
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.4
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.5
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.5
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.6
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.6
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.7
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.7
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.8
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.8
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.9
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.9
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 9.1
Comparison 9 Continuous infusion of…
Analysis 9.1
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 1…
Analysis 9.2
Comparison 9 Continuous infusion of…
Analysis 9.2
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 2…
Analysis 9.3
Comparison 9 Continuous infusion of…
Analysis 9.3
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 3…
Analysis 9.4
Comparison 9 Continuous infusion of…
Analysis 9.4
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 4…
Analysis 9.5
Comparison 9 Continuous infusion of…
Analysis 9.5
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 5…
Analysis 9.6
Comparison 9 Continuous infusion of…
Analysis 9.6
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 6…
Analysis 9.7
Comparison 9 Continuous infusion of…
Analysis 9.7
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 7…
Analysis 9.8
Comparison 9 Continuous infusion of…
Analysis 9.8
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 8…
Analysis 9.9
Comparison 9 Continuous infusion of…
Analysis 9.9
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 9…
Analysis 9.10
Comparison 9 Continuous infusion of…
Analysis 9.10
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 10…
Analysis 9.11
Comparison 9 Continuous infusion of…
Analysis 9.11
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 11…
Analysis 9.12
Comparison 9 Continuous infusion of…
Analysis 9.12
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 12…
Analysis 9.13
Comparison 9 Continuous infusion of…
Analysis 9.13
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 13…
Analysis 9.14
Comparison 9 Continuous infusion of…
Analysis 9.14
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 14…
Analysis 9.15
Comparison 9 Continuous infusion of…
Analysis 9.15
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 15…
Analysis 10.1
Comparison 10 Rectal ibuprofen versus…
Analysis 10.1
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 1 Failure to close a…
Analysis 10.2
Comparison 10 Rectal ibuprofen versus…
Analysis 10.2
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 2 Need for surgical ligation.
Analysis 10.3
Comparison 10 Rectal ibuprofen versus…
Analysis 10.3
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 3 Plasma creatinine (µmol/L.
Analysis 10.4
Comparison 10 Rectal ibuprofen versus…
Analysis 10.4
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 4 Plasma bilirubin (µmol/L) after…
Analysis 10.5
Comparison 10 Rectal ibuprofen versus…
Analysis 10.5
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 5 Urine output (mL/kg/hr) after…
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2015 Feb 18;(2):CD003481. doi: 10.1002/14651858.CD003481.pub6. Cochrane Database Syst Rev. 2015. PMID: 25692606 Updated. Review.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Feb 11;2(2):CD003481. doi: 10.1002/14651858.CD003481.pub8. Cochrane Database Syst Rev. 2020. PMID: 32045960 Free PMC article.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2015 Feb 18;(2):CD003481. doi: 10.1002/14651858.CD003481.pub6. Cochrane Database Syst Rev. 2015. PMID: 25692606 Updated. Review.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD003481. doi: 10.1002/14651858.CD003481.pub5. Cochrane Database Syst Rev. 2013. PMID: 23633310 Updated. Review.
- Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants.Ohlsson A, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Jan 27;1(1):CD004213. doi: 10.1002/14651858.CD004213.pub5. Cochrane Database Syst Rev. 2020. PMID: 31985838 Free PMC article.
- Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.Ohlsson A, Shah PS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Jan 27;1(1):CD010061. doi: 10.1002/14651858.CD010061.pub4. Cochrane Database Syst Rev. 2020. PMID: 31985831 Free PMC article. Updated.
- Comparative Effectiveness of Surgical Ligation and Catheter Closure of Patent Ductus Arteriosus in Preterm Infants.Tabb C Jr, Aggarwal S, Bajaj M, Natarajan G. Tabb C Jr, et al. Pediatr Cardiol. 2023 Jun 14. doi: 10.1007/s00246-023-03199-6. Online ahead of print. Pediatr Cardiol. 2023. PMID: 37316609
- Perinatal origins of bronchopulmonary dysplasia-deciphering normal and impaired lung development cell by cell.Mižíková I, Thébaud B. Mižíková I, et al. Mol Cell Pediatr. 2023 Apr 18;10(1):4. doi: 10.1186/s40348-023-00158-2. Mol Cell Pediatr. 2023. PMID: 37072570 Free PMC article. Review.
- Association between endotypes of prematurity and pharmacological closure of patent ductus arteriosus: A systematic review and meta-analysis.Gonzalez-Luis GE, Borges-Lujan M, Villamor E. Gonzalez-Luis GE, et al. Front Pediatr. 2023 Mar 3;11:1078506. doi: 10.3389/fped.2023.1078506. eCollection 2023. Front Pediatr. 2023. PMID: 36937978 Free PMC article.
- Vascular and pulmonary effects of ibuprofen on neonatal lung development.Chen X, Han D, Wang X, Huang X, Huang Z, Liu Y, Zhong J, Walther FJ, Yang C, Wagenaar GTM. Chen X, et al. Respir Res. 2023 Feb 2;24(1):39. doi: 10.1186/s12931-023-02342-4. Respir Res. 2023. PMID: 36732726 Free PMC article.
- Impact of patent ductus arteriosus shunt size and duration on risk of death or severe respiratory morbidity in preterm infants born in China.Deng Y, Zhang H, Zhao Z, Du J, Bai R, McNamara PJ. Deng Y, et al. Eur J Pediatr. 2022 Aug;181(8):3131-3140. doi: 10.1007/s00431-022-04549-x. Epub 2022 Jul 15. Eur J Pediatr. 2022. PMID: 35838780 Free PMC article.
- Meta-Analysis
- Review
- Systematic Review
- Administration, Oral
- Cyclooxygenase Inhibitors / adverse effects
- Cyclooxygenase Inhibitors / therapeutic use*
- Ductus Arteriosus, Patent / drug therapy*
- Enterocolitis, Necrotizing / prevention & control
- Humans
- Ibuprofen / adverse effects
- Ibuprofen / therapeutic use*
- Indomethacin / adverse effects
- Indomethacin / therapeutic use
- Infant, Low Birth Weight*
- Infant, Newborn
- Infant, Premature*
- Injections, Intravenous
- Randomized Controlled Trials as Topic
- Treatment Failure
- Cyclooxygenase Inhibitors
- Ibuprofen
- Indomethacin
- Full Text Sources
- Other Literature Sources
- Medical
- Miscellaneous
NCBI Literature Resources
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![Analysis 1.16](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-001-16.jpg)
![Analysis 1.17](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-001-17.jpg)
![Analysis 1.18](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-001-18.jpg)
![Analysis 2.1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-002-01.jpg)
![Analysis 3.1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-01.jpg)
![Analysis 3.2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-02.jpg)
![Analysis 3.3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-03.jpg)
![Analysis 3.4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-04.jpg)
![Analysis 3.5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-05.jpg)
![Analysis 3.6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-06.jpg)
![Analysis 3.7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-07.jpg)
![Analysis 3.8](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-08.jpg)
![Analysis 3.9](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-09.jpg)
![Analysis 3.10](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-10.jpg)
![Analysis 3.11](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-11.jpg)
![Analysis 3.12](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-12.jpg)
![Analysis 3.13](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-13.jpg)
![Analysis 3.14](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-14.jpg)
![Analysis 3.15](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-15.jpg)
![Analysis 3.16](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-16.jpg)
![Analysis 3.17](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-17.jpg)
![Analysis 3.18](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-18.jpg)
![Analysis 3.19](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-19.jpg)
![Analysis 3.20](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-20.jpg)
![Analysis 3.21](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-21.jpg)
![Analysis 3.22](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-22.jpg)
![Analysis 3.23](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-23.jpg)
![Analysis 3.24](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-24.jpg)
Analysis 3.25
Comparison 3 Intravenous or oral…
Analysis 3.25
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 25…
Analysis 3.26
Comparison 3 Intravenous or oral…
Analysis 3.26
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 26…
Analysis 3.27
Comparison 3 Intravenous or oral…
Analysis 3.27
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 27…
Analysis 3.28
Comparison 3 Intravenous or oral…
Analysis 3.28
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 28…
Analysis 3.29
Comparison 3 Intravenous or oral…
Analysis 3.29
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 29…
Analysis 3.30
Comparison 3 Intravenous or oral…
Analysis 3.30
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 30…
Analysis 3.31
Comparison 3 Intravenous or oral…
Analysis 3.31
Comparison 3 Intravenous or oral ibuprofen versus intravenous or oral indomethacin, Outcome 31…
Analysis 4.1
Comparison 4 Oral ibuprofen versus…
Analysis 4.1
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 1 Failure…
Analysis 4.2
Comparison 4 Oral ibuprofen versus…
Analysis 4.2
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 2 All‐cause…
Analysis 4.3
Comparison 4 Oral ibuprofen versus…
Analysis 4.3
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 3 Neonatal…
Analysis 4.4
Comparison 4 Oral ibuprofen versus…
Analysis 4.4
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 4 Reopening…
Analysis 4.5
Comparison 4 Oral ibuprofen versus…
Analysis 4.5
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 5 Need…
Analysis 4.6
Comparison 4 Oral ibuprofen versus…
Analysis 4.6
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 6 Pulmonary…
Analysis 4.7
Comparison 4 Oral ibuprofen versus…
Analysis 4.7
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 7 Pulmonary…
Analysis 4.8
Comparison 4 Oral ibuprofen versus…
Analysis 4.8
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 8 Chronic…
Analysis 4.9
Comparison 4 Oral ibuprofen versus…
Analysis 4.9
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 9 Chronic…
Analysis 4.10
Comparison 4 Oral ibuprofen versus…
Analysis 4.10
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 10 Intraventricular…
Analysis 4.11
Comparison 4 Oral ibuprofen versus…
Analysis 4.11
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 11 Intraventricular…
Analysis 4.12
Comparison 4 Oral ibuprofen versus…
Analysis 4.12
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 12 Periventricular…
Analysis 4.13
Comparison 4 Oral ibuprofen versus…
Analysis 4.13
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 13 Necrotising…
Analysis 4.14
Comparison 4 Oral ibuprofen versus…
Analysis 4.14
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 14 Intestinal…
Analysis 4.15
Comparison 4 Oral ibuprofen versus…
Analysis 4.15
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 15 Gastrointestinal…
Analysis 4.16
Comparison 4 Oral ibuprofen versus…
Analysis 4.16
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 16 Retinopathy…
Analysis 4.17
Comparison 4 Oral ibuprofen versus…
Analysis 4.17
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 17 Sepsis.
Analysis 4.18
Comparison 4 Oral ibuprofen versus…
Analysis 4.18
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 18 Oliguria…
Analysis 4.19
Comparison 4 Oral ibuprofen versus…
Analysis 4.19
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 19 Serum/plasma…
Analysis 4.20
Comparison 4 Oral ibuprofen versus…
Analysis 4.20
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 20 Duration…
Analysis 5.1
Comparison 5 Oral ibuprofen versus…
Analysis 5.1
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 1 Failure to close…
Analysis 5.2
Comparison 5 Oral ibuprofen versus…
Analysis 5.2
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 2 Mortality (during first…
Analysis 5.3
Comparison 5 Oral ibuprofen versus…
Analysis 5.3
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 3 Mortality (during hospital…
Analysis 5.4
Comparison 5 Oral ibuprofen versus…
Analysis 5.4
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 4 Mean plasma cystatin‐C…
Analysis 5.5
Comparison 5 Oral ibuprofen versus…
Analysis 5.5
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 5 Need for surgical…
Analysis 5.6
Comparison 5 Oral ibuprofen versus…
Analysis 5.6
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 6 Duration of ventilatory…
Analysis 5.7
Comparison 5 Oral ibuprofen versus…
Analysis 5.7
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 7 Duration of hospitalisation…
Analysis 5.8
Comparison 5 Oral ibuprofen versus…
Analysis 5.8
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 8 Pneumothorax.
Analysis 5.9
Comparison 5 Oral ibuprofen versus…
Analysis 5.9
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 9 Pulmonary haemorrhage.
Analysis 5.10
Comparison 5 Oral ibuprofen versus…
Analysis 5.10
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 10 Pulmonary hypertension.
Analysis 5.11
Comparison 5 Oral ibuprofen versus…
Analysis 5.11
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 11 Chronic lung disease…
Analysis 5.12
Comparison 5 Oral ibuprofen versus…
Analysis 5.12
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 12 Intraventricular haemorrhage (any…
Analysis 5.13
Comparison 5 Oral ibuprofen versus…
Analysis 5.13
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 13 Periventricular leukomalacia.
Analysis 5.14
Comparison 5 Oral ibuprofen versus…
Analysis 5.14
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 14 Necrotising enterocolitis (any…
Analysis 5.15
Comparison 5 Oral ibuprofen versus…
Analysis 5.15
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 15 Intestinal perforation.
Analysis 5.16
Comparison 5 Oral ibuprofen versus…
Analysis 5.16
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 16 Gastrointestinal bleed.
Analysis 5.17
Comparison 5 Oral ibuprofen versus…
Analysis 5.17
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 17 Sepsis.
Analysis 5.18
Comparison 5 Oral ibuprofen versus…
Analysis 5.18
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 18 Retinopathy of prematurity…
Analysis 5.19
Comparison 5 Oral ibuprofen versus…
Analysis 5.19
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 19 Serum/plasma creatinine levels…
Analysis 5.20
Comparison 5 Oral ibuprofen versus…
Analysis 5.20
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 20 Oliguria (Urine output…
Analysis 5.21
Comparison 5 Oral ibuprofen versus…
Analysis 5.21
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 21 Mental Developmental Index…
Analysis 5.22
Comparison 5 Oral ibuprofen versus…
Analysis 5.22
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 22 Psychomotor Developmental Index…
Analysis 5.23
Comparison 5 Oral ibuprofen versus…
Analysis 5.23
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 23 Moderate/severe cerebral palsy…
Analysis 5.24
Comparison 5 Oral ibuprofen versus…
Analysis 5.24
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 24 Blindness at 18‐24…
Analysis 5.25
Comparison 5 Oral ibuprofen versus…
Analysis 5.25
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 25 Deafness at 18‐24…
Analysis 6.1
Comparison 6 High‐dose (oral or…
Analysis 6.1
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.2
Comparison 6 High‐dose (oral or…
Analysis 6.2
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.3
Comparison 6 High‐dose (oral or…
Analysis 6.3
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.4
Comparison 6 High‐dose (oral or…
Analysis 6.4
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.5
Comparison 6 High‐dose (oral or…
Analysis 6.5
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.6
Comparison 6 High‐dose (oral or…
Analysis 6.6
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.7
Comparison 6 High‐dose (oral or…
Analysis 6.7
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.8
Comparison 6 High‐dose (oral or…
Analysis 6.8
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.9
Comparison 6 High‐dose (oral or…
Analysis 6.9
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.10
Comparison 6 High‐dose (oral or…
Analysis 6.10
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.11
Comparison 6 High‐dose (oral or…
Analysis 6.11
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.12
Comparison 6 High‐dose (oral or…
Analysis 6.12
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.13
Comparison 6 High‐dose (oral or…
Analysis 6.13
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.14
Comparison 6 High‐dose (oral or…
Analysis 6.14
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.15
Comparison 6 High‐dose (oral or…
Analysis 6.15
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.16
Comparison 6 High‐dose (oral or…
Analysis 6.16
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.17
Comparison 6 High‐dose (oral or…
Analysis 6.17
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.18
Comparison 6 High‐dose (oral or…
Analysis 6.18
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.19
Comparison 6 High‐dose (oral or…
Analysis 6.19
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 7.1
Comparison 7 Early versus expectant…
Analysis 7.1
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 1 Days on…
Analysis 7.2
Comparison 7 Early versus expectant…
Analysis 7.2
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 2 Days on…
Analysis 7.3
Comparison 7 Early versus expectant…
Analysis 7.3
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 3 Days on…
Analysis 7.4
Comparison 7 Early versus expectant…
Analysis 7.4
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 4 Days on…
Analysis 7.5
Comparison 7 Early versus expectant…
Analysis 7.5
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 5 Chronic lung…
Analysis 7.6
Comparison 7 Early versus expectant…
Analysis 7.6
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 6 Mortality or…
Analysis 7.7
Comparison 7 Early versus expectant…
Analysis 7.7
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 7 Mortality during…
Analysis 7.8
Comparison 7 Early versus expectant…
Analysis 7.8
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 8 Pneumothorax.
Analysis 7.9
Comparison 7 Early versus expectant…
Analysis 7.9
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 9 Intraventricular haemorrhage…
Analysis 7.10
Comparison 7 Early versus expectant…
Analysis 7.10
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 10 Periventricular leukomalacia.
Analysis 7.11
Comparison 7 Early versus expectant…
Analysis 7.11
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 11 Necrotising enterocolitis…
Analysis 7.12
Comparison 7 Early versus expectant…
Analysis 7.12
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 12 Intestinal perforation.
Analysis 7.13
Comparison 7 Early versus expectant…
Analysis 7.13
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 13 Sepsis.
Analysis 7.14
Comparison 7 Early versus expectant…
Analysis 7.14
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 14 Retinopathy of…
Analysis 8.1
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.1
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.2
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.2
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.3
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.3
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.4
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.4
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.5
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.5
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.6
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.6
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.7
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.7
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.8
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.8
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.9
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.9
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 9.1
Comparison 9 Continuous infusion of…
Analysis 9.1
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 1…
Analysis 9.2
Comparison 9 Continuous infusion of…
Analysis 9.2
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 2…
Analysis 9.3
Comparison 9 Continuous infusion of…
Analysis 9.3
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 3…
Analysis 9.4
Comparison 9 Continuous infusion of…
Analysis 9.4
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 4…
Analysis 9.5
Comparison 9 Continuous infusion of…
Analysis 9.5
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 5…
Analysis 9.6
Comparison 9 Continuous infusion of…
Analysis 9.6
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 6…
Analysis 9.7
Comparison 9 Continuous infusion of…
Analysis 9.7
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 7…
Analysis 9.8
Comparison 9 Continuous infusion of…
Analysis 9.8
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 8…
Analysis 9.9
Comparison 9 Continuous infusion of…
Analysis 9.9
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 9…
Analysis 9.10
Comparison 9 Continuous infusion of…
Analysis 9.10
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 10…
Analysis 9.11
Comparison 9 Continuous infusion of…
Analysis 9.11
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 11…
Analysis 9.12
Comparison 9 Continuous infusion of…
Analysis 9.12
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 12…
Analysis 9.13
Comparison 9 Continuous infusion of…
Analysis 9.13
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 13…
Analysis 9.14
Comparison 9 Continuous infusion of…
Analysis 9.14
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 14…
Analysis 9.15
Comparison 9 Continuous infusion of…
Analysis 9.15
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 15…
Analysis 10.1
Comparison 10 Rectal ibuprofen versus…
Analysis 10.1
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 1 Failure to close a…
Analysis 10.2
Comparison 10 Rectal ibuprofen versus…
Analysis 10.2
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 2 Need for surgical ligation.
Analysis 10.3
Comparison 10 Rectal ibuprofen versus…
Analysis 10.3
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 3 Plasma creatinine (µmol/L.
Analysis 10.4
Comparison 10 Rectal ibuprofen versus…
Analysis 10.4
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 4 Plasma bilirubin (µmol/L) after…
Analysis 10.5
Comparison 10 Rectal ibuprofen versus…
Analysis 10.5
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 5 Urine output (mL/kg/hr) after…
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2015 Feb 18;(2):CD003481. doi: 10.1002/14651858.CD003481.pub6. Cochrane Database Syst Rev. 2015. PMID: 25692606 Updated. Review.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Feb 11;2(2):CD003481. doi: 10.1002/14651858.CD003481.pub8. Cochrane Database Syst Rev. 2020. PMID: 32045960 Free PMC article.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2015 Feb 18;(2):CD003481. doi: 10.1002/14651858.CD003481.pub6. Cochrane Database Syst Rev. 2015. PMID: 25692606 Updated. Review.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD003481. doi: 10.1002/14651858.CD003481.pub5. Cochrane Database Syst Rev. 2013. PMID: 23633310 Updated. Review.
- Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants.Ohlsson A, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Jan 27;1(1):CD004213. doi: 10.1002/14651858.CD004213.pub5. Cochrane Database Syst Rev. 2020. PMID: 31985838 Free PMC article.
- Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.Ohlsson A, Shah PS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Jan 27;1(1):CD010061. doi: 10.1002/14651858.CD010061.pub4. Cochrane Database Syst Rev. 2020. PMID: 31985831 Free PMC article. Updated.
- Comparative Effectiveness of Surgical Ligation and Catheter Closure of Patent Ductus Arteriosus in Preterm Infants.Tabb C Jr, Aggarwal S, Bajaj M, Natarajan G. Tabb C Jr, et al. Pediatr Cardiol. 2023 Jun 14. doi: 10.1007/s00246-023-03199-6. Online ahead of print. Pediatr Cardiol. 2023. PMID: 37316609
- Perinatal origins of bronchopulmonary dysplasia-deciphering normal and impaired lung development cell by cell.Mižíková I, Thébaud B. Mižíková I, et al. Mol Cell Pediatr. 2023 Apr 18;10(1):4. doi: 10.1186/s40348-023-00158-2. Mol Cell Pediatr. 2023. PMID: 37072570 Free PMC article. Review.
- Association between endotypes of prematurity and pharmacological closure of patent ductus arteriosus: A systematic review and meta-analysis.Gonzalez-Luis GE, Borges-Lujan M, Villamor E. Gonzalez-Luis GE, et al. Front Pediatr. 2023 Mar 3;11:1078506. doi: 10.3389/fped.2023.1078506. eCollection 2023. Front Pediatr. 2023. PMID: 36937978 Free PMC article.
- Vascular and pulmonary effects of ibuprofen on neonatal lung development.Chen X, Han D, Wang X, Huang X, Huang Z, Liu Y, Zhong J, Walther FJ, Yang C, Wagenaar GTM. Chen X, et al. Respir Res. 2023 Feb 2;24(1):39. doi: 10.1186/s12931-023-02342-4. Respir Res. 2023. PMID: 36732726 Free PMC article.
- Impact of patent ductus arteriosus shunt size and duration on risk of death or severe respiratory morbidity in preterm infants born in China.Deng Y, Zhang H, Zhao Z, Du J, Bai R, McNamara PJ. Deng Y, et al. Eur J Pediatr. 2022 Aug;181(8):3131-3140. doi: 10.1007/s00431-022-04549-x. Epub 2022 Jul 15. Eur J Pediatr. 2022. PMID: 35838780 Free PMC article.
- Meta-Analysis
- Review
- Systematic Review
- Administration, Oral
- Cyclooxygenase Inhibitors / adverse effects
- Cyclooxygenase Inhibitors / therapeutic use*
- Ductus Arteriosus, Patent / drug therapy*
- Enterocolitis, Necrotizing / prevention & control
- Humans
- Ibuprofen / adverse effects
- Ibuprofen / therapeutic use*
- Indomethacin / adverse effects
- Indomethacin / therapeutic use
- Infant, Low Birth Weight*
- Infant, Newborn
- Infant, Premature*
- Injections, Intravenous
- Randomized Controlled Trials as Topic
- Treatment Failure
- Cyclooxygenase Inhibitors
- Ibuprofen
- Indomethacin
- Full Text Sources
- Other Literature Sources
- Medical
- Miscellaneous
NCBI Literature Resources
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![Analysis 3.25](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-25.jpg)
![Analysis 3.26](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-26.jpg)
![Analysis 3.27](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-27.jpg)
![Analysis 3.28](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-28.jpg)
![Analysis 3.29](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-29.jpg)
![Analysis 3.30](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-30.jpg)
![Analysis 3.31](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-003-31.jpg)
![Analysis 4.1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-01.jpg)
![Analysis 4.2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-02.jpg)
![Analysis 4.3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-03.jpg)
![Analysis 4.4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-04.jpg)
![Analysis 4.5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-05.jpg)
![Analysis 4.6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-06.jpg)
![Analysis 4.7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-07.jpg)
![Analysis 4.8](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-08.jpg)
![Analysis 4.9](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-09.jpg)
![Analysis 4.10](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-10.jpg)
![Analysis 4.11](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-11.jpg)
![Analysis 4.12](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-12.jpg)
![Analysis 4.13](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-13.jpg)
![Analysis 4.14](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-14.jpg)
![Analysis 4.15](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-15.jpg)
![Analysis 4.16](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-16.jpg)
![Analysis 4.17](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-17.jpg)
![Analysis 4.18](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-18.jpg)
Analysis 4.19
Comparison 4 Oral ibuprofen versus…
Analysis 4.19
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 19 Serum/plasma…
Analysis 4.20
Comparison 4 Oral ibuprofen versus…
Analysis 4.20
Comparison 4 Oral ibuprofen versus intravenous (IV) or oral indomethacin, Outcome 20 Duration…
Analysis 5.1
Comparison 5 Oral ibuprofen versus…
Analysis 5.1
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 1 Failure to close…
Analysis 5.2
Comparison 5 Oral ibuprofen versus…
Analysis 5.2
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 2 Mortality (during first…
Analysis 5.3
Comparison 5 Oral ibuprofen versus…
Analysis 5.3
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 3 Mortality (during hospital…
Analysis 5.4
Comparison 5 Oral ibuprofen versus…
Analysis 5.4
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 4 Mean plasma cystatin‐C…
Analysis 5.5
Comparison 5 Oral ibuprofen versus…
Analysis 5.5
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 5 Need for surgical…
Analysis 5.6
Comparison 5 Oral ibuprofen versus…
Analysis 5.6
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 6 Duration of ventilatory…
Analysis 5.7
Comparison 5 Oral ibuprofen versus…
Analysis 5.7
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 7 Duration of hospitalisation…
Analysis 5.8
Comparison 5 Oral ibuprofen versus…
Analysis 5.8
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 8 Pneumothorax.
Analysis 5.9
Comparison 5 Oral ibuprofen versus…
Analysis 5.9
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 9 Pulmonary haemorrhage.
Analysis 5.10
Comparison 5 Oral ibuprofen versus…
Analysis 5.10
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 10 Pulmonary hypertension.
Analysis 5.11
Comparison 5 Oral ibuprofen versus…
Analysis 5.11
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 11 Chronic lung disease…
Analysis 5.12
Comparison 5 Oral ibuprofen versus…
Analysis 5.12
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 12 Intraventricular haemorrhage (any…
Analysis 5.13
Comparison 5 Oral ibuprofen versus…
Analysis 5.13
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 13 Periventricular leukomalacia.
Analysis 5.14
Comparison 5 Oral ibuprofen versus…
Analysis 5.14
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 14 Necrotising enterocolitis (any…
Analysis 5.15
Comparison 5 Oral ibuprofen versus…
Analysis 5.15
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 15 Intestinal perforation.
Analysis 5.16
Comparison 5 Oral ibuprofen versus…
Analysis 5.16
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 16 Gastrointestinal bleed.
Analysis 5.17
Comparison 5 Oral ibuprofen versus…
Analysis 5.17
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 17 Sepsis.
Analysis 5.18
Comparison 5 Oral ibuprofen versus…
Analysis 5.18
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 18 Retinopathy of prematurity…
Analysis 5.19
Comparison 5 Oral ibuprofen versus…
Analysis 5.19
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 19 Serum/plasma creatinine levels…
Analysis 5.20
Comparison 5 Oral ibuprofen versus…
Analysis 5.20
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 20 Oliguria (Urine output…
Analysis 5.21
Comparison 5 Oral ibuprofen versus…
Analysis 5.21
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 21 Mental Developmental Index…
Analysis 5.22
Comparison 5 Oral ibuprofen versus…
Analysis 5.22
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 22 Psychomotor Developmental Index…
Analysis 5.23
Comparison 5 Oral ibuprofen versus…
Analysis 5.23
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 23 Moderate/severe cerebral palsy…
Analysis 5.24
Comparison 5 Oral ibuprofen versus…
Analysis 5.24
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 24 Blindness at 18‐24…
Analysis 5.25
Comparison 5 Oral ibuprofen versus…
Analysis 5.25
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 25 Deafness at 18‐24…
Analysis 6.1
Comparison 6 High‐dose (oral or…
Analysis 6.1
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.2
Comparison 6 High‐dose (oral or…
Analysis 6.2
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.3
Comparison 6 High‐dose (oral or…
Analysis 6.3
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.4
Comparison 6 High‐dose (oral or…
Analysis 6.4
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.5
Comparison 6 High‐dose (oral or…
Analysis 6.5
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.6
Comparison 6 High‐dose (oral or…
Analysis 6.6
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.7
Comparison 6 High‐dose (oral or…
Analysis 6.7
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.8
Comparison 6 High‐dose (oral or…
Analysis 6.8
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.9
Comparison 6 High‐dose (oral or…
Analysis 6.9
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.10
Comparison 6 High‐dose (oral or…
Analysis 6.10
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.11
Comparison 6 High‐dose (oral or…
Analysis 6.11
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.12
Comparison 6 High‐dose (oral or…
Analysis 6.12
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.13
Comparison 6 High‐dose (oral or…
Analysis 6.13
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.14
Comparison 6 High‐dose (oral or…
Analysis 6.14
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.15
Comparison 6 High‐dose (oral or…
Analysis 6.15
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.16
Comparison 6 High‐dose (oral or…
Analysis 6.16
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.17
Comparison 6 High‐dose (oral or…
Analysis 6.17
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.18
Comparison 6 High‐dose (oral or…
Analysis 6.18
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.19
Comparison 6 High‐dose (oral or…
Analysis 6.19
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 7.1
Comparison 7 Early versus expectant…
Analysis 7.1
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 1 Days on…
Analysis 7.2
Comparison 7 Early versus expectant…
Analysis 7.2
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 2 Days on…
Analysis 7.3
Comparison 7 Early versus expectant…
Analysis 7.3
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 3 Days on…
Analysis 7.4
Comparison 7 Early versus expectant…
Analysis 7.4
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 4 Days on…
Analysis 7.5
Comparison 7 Early versus expectant…
Analysis 7.5
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 5 Chronic lung…
Analysis 7.6
Comparison 7 Early versus expectant…
Analysis 7.6
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 6 Mortality or…
Analysis 7.7
Comparison 7 Early versus expectant…
Analysis 7.7
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 7 Mortality during…
Analysis 7.8
Comparison 7 Early versus expectant…
Analysis 7.8
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 8 Pneumothorax.
Analysis 7.9
Comparison 7 Early versus expectant…
Analysis 7.9
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 9 Intraventricular haemorrhage…
Analysis 7.10
Comparison 7 Early versus expectant…
Analysis 7.10
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 10 Periventricular leukomalacia.
Analysis 7.11
Comparison 7 Early versus expectant…
Analysis 7.11
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 11 Necrotising enterocolitis…
Analysis 7.12
Comparison 7 Early versus expectant…
Analysis 7.12
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 12 Intestinal perforation.
Analysis 7.13
Comparison 7 Early versus expectant…
Analysis 7.13
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 13 Sepsis.
Analysis 7.14
Comparison 7 Early versus expectant…
Analysis 7.14
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 14 Retinopathy of…
Analysis 8.1
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.1
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.2
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.2
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.3
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.3
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.4
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.4
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.5
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.5
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.6
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.6
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.7
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.7
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.8
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.8
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.9
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.9
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 9.1
Comparison 9 Continuous infusion of…
Analysis 9.1
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 1…
Analysis 9.2
Comparison 9 Continuous infusion of…
Analysis 9.2
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 2…
Analysis 9.3
Comparison 9 Continuous infusion of…
Analysis 9.3
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 3…
Analysis 9.4
Comparison 9 Continuous infusion of…
Analysis 9.4
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 4…
Analysis 9.5
Comparison 9 Continuous infusion of…
Analysis 9.5
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 5…
Analysis 9.6
Comparison 9 Continuous infusion of…
Analysis 9.6
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 6…
Analysis 9.7
Comparison 9 Continuous infusion of…
Analysis 9.7
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 7…
Analysis 9.8
Comparison 9 Continuous infusion of…
Analysis 9.8
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 8…
Analysis 9.9
Comparison 9 Continuous infusion of…
Analysis 9.9
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 9…
Analysis 9.10
Comparison 9 Continuous infusion of…
Analysis 9.10
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 10…
Analysis 9.11
Comparison 9 Continuous infusion of…
Analysis 9.11
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 11…
Analysis 9.12
Comparison 9 Continuous infusion of…
Analysis 9.12
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 12…
Analysis 9.13
Comparison 9 Continuous infusion of…
Analysis 9.13
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 13…
Analysis 9.14
Comparison 9 Continuous infusion of…
Analysis 9.14
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 14…
Analysis 9.15
Comparison 9 Continuous infusion of…
Analysis 9.15
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 15…
Analysis 10.1
Comparison 10 Rectal ibuprofen versus…
Analysis 10.1
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 1 Failure to close a…
Analysis 10.2
Comparison 10 Rectal ibuprofen versus…
Analysis 10.2
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 2 Need for surgical ligation.
Analysis 10.3
Comparison 10 Rectal ibuprofen versus…
Analysis 10.3
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 3 Plasma creatinine (µmol/L.
Analysis 10.4
Comparison 10 Rectal ibuprofen versus…
Analysis 10.4
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 4 Plasma bilirubin (µmol/L) after…
Analysis 10.5
Comparison 10 Rectal ibuprofen versus…
Analysis 10.5
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 5 Urine output (mL/kg/hr) after…
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2015 Feb 18;(2):CD003481. doi: 10.1002/14651858.CD003481.pub6. Cochrane Database Syst Rev. 2015. PMID: 25692606 Updated. Review.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Feb 11;2(2):CD003481. doi: 10.1002/14651858.CD003481.pub8. Cochrane Database Syst Rev. 2020. PMID: 32045960 Free PMC article.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2015 Feb 18;(2):CD003481. doi: 10.1002/14651858.CD003481.pub6. Cochrane Database Syst Rev. 2015. PMID: 25692606 Updated. Review.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD003481. doi: 10.1002/14651858.CD003481.pub5. Cochrane Database Syst Rev. 2013. PMID: 23633310 Updated. Review.
- Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants.Ohlsson A, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Jan 27;1(1):CD004213. doi: 10.1002/14651858.CD004213.pub5. Cochrane Database Syst Rev. 2020. PMID: 31985838 Free PMC article.
- Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.Ohlsson A, Shah PS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Jan 27;1(1):CD010061. doi: 10.1002/14651858.CD010061.pub4. Cochrane Database Syst Rev. 2020. PMID: 31985831 Free PMC article. Updated.
- Comparative Effectiveness of Surgical Ligation and Catheter Closure of Patent Ductus Arteriosus in Preterm Infants.Tabb C Jr, Aggarwal S, Bajaj M, Natarajan G. Tabb C Jr, et al. Pediatr Cardiol. 2023 Jun 14. doi: 10.1007/s00246-023-03199-6. Online ahead of print. Pediatr Cardiol. 2023. PMID: 37316609
- Perinatal origins of bronchopulmonary dysplasia-deciphering normal and impaired lung development cell by cell.Mižíková I, Thébaud B. Mižíková I, et al. Mol Cell Pediatr. 2023 Apr 18;10(1):4. doi: 10.1186/s40348-023-00158-2. Mol Cell Pediatr. 2023. PMID: 37072570 Free PMC article. Review.
- Association between endotypes of prematurity and pharmacological closure of patent ductus arteriosus: A systematic review and meta-analysis.Gonzalez-Luis GE, Borges-Lujan M, Villamor E. Gonzalez-Luis GE, et al. Front Pediatr. 2023 Mar 3;11:1078506. doi: 10.3389/fped.2023.1078506. eCollection 2023. Front Pediatr. 2023. PMID: 36937978 Free PMC article.
- Vascular and pulmonary effects of ibuprofen on neonatal lung development.Chen X, Han D, Wang X, Huang X, Huang Z, Liu Y, Zhong J, Walther FJ, Yang C, Wagenaar GTM. Chen X, et al. Respir Res. 2023 Feb 2;24(1):39. doi: 10.1186/s12931-023-02342-4. Respir Res. 2023. PMID: 36732726 Free PMC article.
- Impact of patent ductus arteriosus shunt size and duration on risk of death or severe respiratory morbidity in preterm infants born in China.Deng Y, Zhang H, Zhao Z, Du J, Bai R, McNamara PJ. Deng Y, et al. Eur J Pediatr. 2022 Aug;181(8):3131-3140. doi: 10.1007/s00431-022-04549-x. Epub 2022 Jul 15. Eur J Pediatr. 2022. PMID: 35838780 Free PMC article.
- Meta-Analysis
- Review
- Systematic Review
- Administration, Oral
- Cyclooxygenase Inhibitors / adverse effects
- Cyclooxygenase Inhibitors / therapeutic use*
- Ductus Arteriosus, Patent / drug therapy*
- Enterocolitis, Necrotizing / prevention & control
- Humans
- Ibuprofen / adverse effects
- Ibuprofen / therapeutic use*
- Indomethacin / adverse effects
- Indomethacin / therapeutic use
- Infant, Low Birth Weight*
- Infant, Newborn
- Infant, Premature*
- Injections, Intravenous
- Randomized Controlled Trials as Topic
- Treatment Failure
- Cyclooxygenase Inhibitors
- Ibuprofen
- Indomethacin
- Full Text Sources
- Other Literature Sources
- Medical
- Miscellaneous
NCBI Literature Resources
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![Analysis 4.19](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-19.jpg)
![Analysis 4.20](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-004-20.jpg)
![Analysis 5.1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-01.jpg)
![Analysis 5.2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-02.jpg)
![Analysis 5.3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-03.jpg)
![Analysis 5.4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-04.jpg)
![Analysis 5.5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-05.jpg)
![Analysis 5.6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-06.jpg)
![Analysis 5.7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-07.jpg)
![Analysis 5.8](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-08.jpg)
![Analysis 5.9](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-09.jpg)
![Analysis 5.10](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-10.jpg)
![Analysis 5.11](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-11.jpg)
![Analysis 5.12](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-12.jpg)
![Analysis 5.13](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-13.jpg)
![Analysis 5.14](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-14.jpg)
![Analysis 5.15](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-15.jpg)
![Analysis 5.16](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-16.jpg)
![Analysis 5.17](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-17.jpg)
![Analysis 5.18](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-18.jpg)
![Analysis 5.19](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-19.jpg)
![Analysis 5.20](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-20.jpg)
Analysis 5.21
Comparison 5 Oral ibuprofen versus…
Analysis 5.21
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 21 Mental Developmental Index…
Analysis 5.22
Comparison 5 Oral ibuprofen versus…
Analysis 5.22
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 22 Psychomotor Developmental Index…
Analysis 5.23
Comparison 5 Oral ibuprofen versus…
Analysis 5.23
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 23 Moderate/severe cerebral palsy…
Analysis 5.24
Comparison 5 Oral ibuprofen versus…
Analysis 5.24
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 24 Blindness at 18‐24…
Analysis 5.25
Comparison 5 Oral ibuprofen versus…
Analysis 5.25
Comparison 5 Oral ibuprofen versus intravenous (IV) ibuprofen, Outcome 25 Deafness at 18‐24…
Analysis 6.1
Comparison 6 High‐dose (oral or…
Analysis 6.1
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.2
Comparison 6 High‐dose (oral or…
Analysis 6.2
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.3
Comparison 6 High‐dose (oral or…
Analysis 6.3
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.4
Comparison 6 High‐dose (oral or…
Analysis 6.4
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.5
Comparison 6 High‐dose (oral or…
Analysis 6.5
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.6
Comparison 6 High‐dose (oral or…
Analysis 6.6
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.7
Comparison 6 High‐dose (oral or…
Analysis 6.7
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.8
Comparison 6 High‐dose (oral or…
Analysis 6.8
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.9
Comparison 6 High‐dose (oral or…
Analysis 6.9
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.10
Comparison 6 High‐dose (oral or…
Analysis 6.10
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.11
Comparison 6 High‐dose (oral or…
Analysis 6.11
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.12
Comparison 6 High‐dose (oral or…
Analysis 6.12
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.13
Comparison 6 High‐dose (oral or…
Analysis 6.13
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.14
Comparison 6 High‐dose (oral or…
Analysis 6.14
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.15
Comparison 6 High‐dose (oral or…
Analysis 6.15
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.16
Comparison 6 High‐dose (oral or…
Analysis 6.16
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.17
Comparison 6 High‐dose (oral or…
Analysis 6.17
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.18
Comparison 6 High‐dose (oral or…
Analysis 6.18
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.19
Comparison 6 High‐dose (oral or…
Analysis 6.19
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 7.1
Comparison 7 Early versus expectant…
Analysis 7.1
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 1 Days on…
Analysis 7.2
Comparison 7 Early versus expectant…
Analysis 7.2
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 2 Days on…
Analysis 7.3
Comparison 7 Early versus expectant…
Analysis 7.3
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 3 Days on…
Analysis 7.4
Comparison 7 Early versus expectant…
Analysis 7.4
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 4 Days on…
Analysis 7.5
Comparison 7 Early versus expectant…
Analysis 7.5
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 5 Chronic lung…
Analysis 7.6
Comparison 7 Early versus expectant…
Analysis 7.6
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 6 Mortality or…
Analysis 7.7
Comparison 7 Early versus expectant…
Analysis 7.7
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 7 Mortality during…
Analysis 7.8
Comparison 7 Early versus expectant…
Analysis 7.8
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 8 Pneumothorax.
Analysis 7.9
Comparison 7 Early versus expectant…
Analysis 7.9
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 9 Intraventricular haemorrhage…
Analysis 7.10
Comparison 7 Early versus expectant…
Analysis 7.10
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 10 Periventricular leukomalacia.
Analysis 7.11
Comparison 7 Early versus expectant…
Analysis 7.11
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 11 Necrotising enterocolitis…
Analysis 7.12
Comparison 7 Early versus expectant…
Analysis 7.12
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 12 Intestinal perforation.
Analysis 7.13
Comparison 7 Early versus expectant…
Analysis 7.13
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 13 Sepsis.
Analysis 7.14
Comparison 7 Early versus expectant…
Analysis 7.14
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 14 Retinopathy of…
Analysis 8.1
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.1
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.2
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.2
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.3
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.3
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.4
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.4
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.5
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.5
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.6
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.6
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.7
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.7
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.8
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.8
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.9
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.9
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 9.1
Comparison 9 Continuous infusion of…
Analysis 9.1
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 1…
Analysis 9.2
Comparison 9 Continuous infusion of…
Analysis 9.2
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 2…
Analysis 9.3
Comparison 9 Continuous infusion of…
Analysis 9.3
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 3…
Analysis 9.4
Comparison 9 Continuous infusion of…
Analysis 9.4
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 4…
Analysis 9.5
Comparison 9 Continuous infusion of…
Analysis 9.5
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 5…
Analysis 9.6
Comparison 9 Continuous infusion of…
Analysis 9.6
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 6…
Analysis 9.7
Comparison 9 Continuous infusion of…
Analysis 9.7
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 7…
Analysis 9.8
Comparison 9 Continuous infusion of…
Analysis 9.8
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 8…
Analysis 9.9
Comparison 9 Continuous infusion of…
Analysis 9.9
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 9…
Analysis 9.10
Comparison 9 Continuous infusion of…
Analysis 9.10
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 10…
Analysis 9.11
Comparison 9 Continuous infusion of…
Analysis 9.11
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 11…
Analysis 9.12
Comparison 9 Continuous infusion of…
Analysis 9.12
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 12…
Analysis 9.13
Comparison 9 Continuous infusion of…
Analysis 9.13
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 13…
Analysis 9.14
Comparison 9 Continuous infusion of…
Analysis 9.14
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 14…
Analysis 9.15
Comparison 9 Continuous infusion of…
Analysis 9.15
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 15…
Analysis 10.1
Comparison 10 Rectal ibuprofen versus…
Analysis 10.1
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 1 Failure to close a…
Analysis 10.2
Comparison 10 Rectal ibuprofen versus…
Analysis 10.2
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 2 Need for surgical ligation.
Analysis 10.3
Comparison 10 Rectal ibuprofen versus…
Analysis 10.3
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 3 Plasma creatinine (µmol/L.
Analysis 10.4
Comparison 10 Rectal ibuprofen versus…
Analysis 10.4
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 4 Plasma bilirubin (µmol/L) after…
Analysis 10.5
Comparison 10 Rectal ibuprofen versus…
Analysis 10.5
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 5 Urine output (mL/kg/hr) after…
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2015 Feb 18;(2):CD003481. doi: 10.1002/14651858.CD003481.pub6. Cochrane Database Syst Rev. 2015. PMID: 25692606 Updated. Review.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Feb 11;2(2):CD003481. doi: 10.1002/14651858.CD003481.pub8. Cochrane Database Syst Rev. 2020. PMID: 32045960 Free PMC article.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2015 Feb 18;(2):CD003481. doi: 10.1002/14651858.CD003481.pub6. Cochrane Database Syst Rev. 2015. PMID: 25692606 Updated. Review.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD003481. doi: 10.1002/14651858.CD003481.pub5. Cochrane Database Syst Rev. 2013. PMID: 23633310 Updated. Review.
- Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants.Ohlsson A, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Jan 27;1(1):CD004213. doi: 10.1002/14651858.CD004213.pub5. Cochrane Database Syst Rev. 2020. PMID: 31985838 Free PMC article.
- Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.Ohlsson A, Shah PS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Jan 27;1(1):CD010061. doi: 10.1002/14651858.CD010061.pub4. Cochrane Database Syst Rev. 2020. PMID: 31985831 Free PMC article. Updated.
- Comparative Effectiveness of Surgical Ligation and Catheter Closure of Patent Ductus Arteriosus in Preterm Infants.Tabb C Jr, Aggarwal S, Bajaj M, Natarajan G. Tabb C Jr, et al. Pediatr Cardiol. 2023 Jun 14. doi: 10.1007/s00246-023-03199-6. Online ahead of print. Pediatr Cardiol. 2023. PMID: 37316609
- Perinatal origins of bronchopulmonary dysplasia-deciphering normal and impaired lung development cell by cell.Mižíková I, Thébaud B. Mižíková I, et al. Mol Cell Pediatr. 2023 Apr 18;10(1):4. doi: 10.1186/s40348-023-00158-2. Mol Cell Pediatr. 2023. PMID: 37072570 Free PMC article. Review.
- Association between endotypes of prematurity and pharmacological closure of patent ductus arteriosus: A systematic review and meta-analysis.Gonzalez-Luis GE, Borges-Lujan M, Villamor E. Gonzalez-Luis GE, et al. Front Pediatr. 2023 Mar 3;11:1078506. doi: 10.3389/fped.2023.1078506. eCollection 2023. Front Pediatr. 2023. PMID: 36937978 Free PMC article.
- Vascular and pulmonary effects of ibuprofen on neonatal lung development.Chen X, Han D, Wang X, Huang X, Huang Z, Liu Y, Zhong J, Walther FJ, Yang C, Wagenaar GTM. Chen X, et al. Respir Res. 2023 Feb 2;24(1):39. doi: 10.1186/s12931-023-02342-4. Respir Res. 2023. PMID: 36732726 Free PMC article.
- Impact of patent ductus arteriosus shunt size and duration on risk of death or severe respiratory morbidity in preterm infants born in China.Deng Y, Zhang H, Zhao Z, Du J, Bai R, McNamara PJ. Deng Y, et al. Eur J Pediatr. 2022 Aug;181(8):3131-3140. doi: 10.1007/s00431-022-04549-x. Epub 2022 Jul 15. Eur J Pediatr. 2022. PMID: 35838780 Free PMC article.
- Meta-Analysis
- Review
- Systematic Review
- Administration, Oral
- Cyclooxygenase Inhibitors / adverse effects
- Cyclooxygenase Inhibitors / therapeutic use*
- Ductus Arteriosus, Patent / drug therapy*
- Enterocolitis, Necrotizing / prevention & control
- Humans
- Ibuprofen / adverse effects
- Ibuprofen / therapeutic use*
- Indomethacin / adverse effects
- Indomethacin / therapeutic use
- Infant, Low Birth Weight*
- Infant, Newborn
- Infant, Premature*
- Injections, Intravenous
- Randomized Controlled Trials as Topic
- Treatment Failure
- Cyclooxygenase Inhibitors
- Ibuprofen
- Indomethacin
- Full Text Sources
- Other Literature Sources
- Medical
- Miscellaneous
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
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![Analysis 5.22](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-22.jpg)
![Analysis 5.23](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-23.jpg)
![Analysis 5.24](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-24.jpg)
![Analysis 5.25](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-005-25.jpg)
![Analysis 6.1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-01.jpg)
![Analysis 6.2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-02.jpg)
![Analysis 6.3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-03.jpg)
![Analysis 6.4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-04.jpg)
![Analysis 6.5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-05.jpg)
![Analysis 6.6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-06.jpg)
Analysis 6.7
Comparison 6 High‐dose (oral or…
Analysis 6.7
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.8
Comparison 6 High‐dose (oral or…
Analysis 6.8
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.9
Comparison 6 High‐dose (oral or…
Analysis 6.9
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.10
Comparison 6 High‐dose (oral or…
Analysis 6.10
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.11
Comparison 6 High‐dose (oral or…
Analysis 6.11
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.12
Comparison 6 High‐dose (oral or…
Analysis 6.12
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.13
Comparison 6 High‐dose (oral or…
Analysis 6.13
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.14
Comparison 6 High‐dose (oral or…
Analysis 6.14
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.15
Comparison 6 High‐dose (oral or…
Analysis 6.15
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.16
Comparison 6 High‐dose (oral or…
Analysis 6.16
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.17
Comparison 6 High‐dose (oral or…
Analysis 6.17
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.18
Comparison 6 High‐dose (oral or…
Analysis 6.18
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.19
Comparison 6 High‐dose (oral or…
Analysis 6.19
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 7.1
Comparison 7 Early versus expectant…
Analysis 7.1
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 1 Days on…
Analysis 7.2
Comparison 7 Early versus expectant…
Analysis 7.2
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 2 Days on…
Analysis 7.3
Comparison 7 Early versus expectant…
Analysis 7.3
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 3 Days on…
Analysis 7.4
Comparison 7 Early versus expectant…
Analysis 7.4
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 4 Days on…
Analysis 7.5
Comparison 7 Early versus expectant…
Analysis 7.5
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 5 Chronic lung…
Analysis 7.6
Comparison 7 Early versus expectant…
Analysis 7.6
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 6 Mortality or…
Analysis 7.7
Comparison 7 Early versus expectant…
Analysis 7.7
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 7 Mortality during…
Analysis 7.8
Comparison 7 Early versus expectant…
Analysis 7.8
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 8 Pneumothorax.
Analysis 7.9
Comparison 7 Early versus expectant…
Analysis 7.9
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 9 Intraventricular haemorrhage…
Analysis 7.10
Comparison 7 Early versus expectant…
Analysis 7.10
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 10 Periventricular leukomalacia.
Analysis 7.11
Comparison 7 Early versus expectant…
Analysis 7.11
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 11 Necrotising enterocolitis…
Analysis 7.12
Comparison 7 Early versus expectant…
Analysis 7.12
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 12 Intestinal perforation.
Analysis 7.13
Comparison 7 Early versus expectant…
Analysis 7.13
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 13 Sepsis.
Analysis 7.14
Comparison 7 Early versus expectant…
Analysis 7.14
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 14 Retinopathy of…
Analysis 8.1
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.1
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.2
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.2
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.3
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.3
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.4
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.4
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.5
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.5
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.6
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.6
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.7
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.7
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.8
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.8
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.9
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.9
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 9.1
Comparison 9 Continuous infusion of…
Analysis 9.1
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 1…
Analysis 9.2
Comparison 9 Continuous infusion of…
Analysis 9.2
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 2…
Analysis 9.3
Comparison 9 Continuous infusion of…
Analysis 9.3
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 3…
Analysis 9.4
Comparison 9 Continuous infusion of…
Analysis 9.4
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 4…
Analysis 9.5
Comparison 9 Continuous infusion of…
Analysis 9.5
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 5…
Analysis 9.6
Comparison 9 Continuous infusion of…
Analysis 9.6
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 6…
Analysis 9.7
Comparison 9 Continuous infusion of…
Analysis 9.7
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 7…
Analysis 9.8
Comparison 9 Continuous infusion of…
Analysis 9.8
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 8…
Analysis 9.9
Comparison 9 Continuous infusion of…
Analysis 9.9
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 9…
Analysis 9.10
Comparison 9 Continuous infusion of…
Analysis 9.10
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 10…
Analysis 9.11
Comparison 9 Continuous infusion of…
Analysis 9.11
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 11…
Analysis 9.12
Comparison 9 Continuous infusion of…
Analysis 9.12
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 12…
Analysis 9.13
Comparison 9 Continuous infusion of…
Analysis 9.13
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 13…
Analysis 9.14
Comparison 9 Continuous infusion of…
Analysis 9.14
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 14…
Analysis 9.15
Comparison 9 Continuous infusion of…
Analysis 9.15
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 15…
Analysis 10.1
Comparison 10 Rectal ibuprofen versus…
Analysis 10.1
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 1 Failure to close a…
Analysis 10.2
Comparison 10 Rectal ibuprofen versus…
Analysis 10.2
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 2 Need for surgical ligation.
Analysis 10.3
Comparison 10 Rectal ibuprofen versus…
Analysis 10.3
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 3 Plasma creatinine (µmol/L.
Analysis 10.4
Comparison 10 Rectal ibuprofen versus…
Analysis 10.4
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 4 Plasma bilirubin (µmol/L) after…
Analysis 10.5
Comparison 10 Rectal ibuprofen versus…
Analysis 10.5
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 5 Urine output (mL/kg/hr) after…
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2015 Feb 18;(2):CD003481. doi: 10.1002/14651858.CD003481.pub6. Cochrane Database Syst Rev. 2015. PMID: 25692606 Updated. Review.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Feb 11;2(2):CD003481. doi: 10.1002/14651858.CD003481.pub8. Cochrane Database Syst Rev. 2020. PMID: 32045960 Free PMC article.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2015 Feb 18;(2):CD003481. doi: 10.1002/14651858.CD003481.pub6. Cochrane Database Syst Rev. 2015. PMID: 25692606 Updated. Review.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD003481. doi: 10.1002/14651858.CD003481.pub5. Cochrane Database Syst Rev. 2013. PMID: 23633310 Updated. Review.
- Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants.Ohlsson A, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Jan 27;1(1):CD004213. doi: 10.1002/14651858.CD004213.pub5. Cochrane Database Syst Rev. 2020. PMID: 31985838 Free PMC article.
- Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.Ohlsson A, Shah PS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Jan 27;1(1):CD010061. doi: 10.1002/14651858.CD010061.pub4. Cochrane Database Syst Rev. 2020. PMID: 31985831 Free PMC article. Updated.
- Comparative Effectiveness of Surgical Ligation and Catheter Closure of Patent Ductus Arteriosus in Preterm Infants.Tabb C Jr, Aggarwal S, Bajaj M, Natarajan G. Tabb C Jr, et al. Pediatr Cardiol. 2023 Jun 14. doi: 10.1007/s00246-023-03199-6. Online ahead of print. Pediatr Cardiol. 2023. PMID: 37316609
- Perinatal origins of bronchopulmonary dysplasia-deciphering normal and impaired lung development cell by cell.Mižíková I, Thébaud B. Mižíková I, et al. Mol Cell Pediatr. 2023 Apr 18;10(1):4. doi: 10.1186/s40348-023-00158-2. Mol Cell Pediatr. 2023. PMID: 37072570 Free PMC article. Review.
- Association between endotypes of prematurity and pharmacological closure of patent ductus arteriosus: A systematic review and meta-analysis.Gonzalez-Luis GE, Borges-Lujan M, Villamor E. Gonzalez-Luis GE, et al. Front Pediatr. 2023 Mar 3;11:1078506. doi: 10.3389/fped.2023.1078506. eCollection 2023. Front Pediatr. 2023. PMID: 36937978 Free PMC article.
- Vascular and pulmonary effects of ibuprofen on neonatal lung development.Chen X, Han D, Wang X, Huang X, Huang Z, Liu Y, Zhong J, Walther FJ, Yang C, Wagenaar GTM. Chen X, et al. Respir Res. 2023 Feb 2;24(1):39. doi: 10.1186/s12931-023-02342-4. Respir Res. 2023. PMID: 36732726 Free PMC article.
- Impact of patent ductus arteriosus shunt size and duration on risk of death or severe respiratory morbidity in preterm infants born in China.Deng Y, Zhang H, Zhao Z, Du J, Bai R, McNamara PJ. Deng Y, et al. Eur J Pediatr. 2022 Aug;181(8):3131-3140. doi: 10.1007/s00431-022-04549-x. Epub 2022 Jul 15. Eur J Pediatr. 2022. PMID: 35838780 Free PMC article.
- Meta-Analysis
- Review
- Systematic Review
- Administration, Oral
- Cyclooxygenase Inhibitors / adverse effects
- Cyclooxygenase Inhibitors / therapeutic use*
- Ductus Arteriosus, Patent / drug therapy*
- Enterocolitis, Necrotizing / prevention & control
- Humans
- Ibuprofen / adverse effects
- Ibuprofen / therapeutic use*
- Indomethacin / adverse effects
- Indomethacin / therapeutic use
- Infant, Low Birth Weight*
- Infant, Newborn
- Infant, Premature*
- Injections, Intravenous
- Randomized Controlled Trials as Topic
- Treatment Failure
- Cyclooxygenase Inhibitors
- Ibuprofen
- Indomethacin
- Full Text Sources
- Other Literature Sources
- Medical
- Miscellaneous
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
![Analysis 6.7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-07.jpg)
![Analysis 6.8](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-08.jpg)
![Analysis 6.9](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-09.jpg)
![Analysis 6.10](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-10.jpg)
![Analysis 6.11](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-11.jpg)
![Analysis 6.12](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-12.jpg)
![Analysis 6.13](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-13.jpg)
![Analysis 6.14](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-14.jpg)
![Analysis 6.15](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-15.jpg)
![Analysis 6.16](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-16.jpg)
Analysis 6.17
Comparison 6 High‐dose (oral or…
Analysis 6.17
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.18
Comparison 6 High‐dose (oral or…
Analysis 6.18
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 6.19
Comparison 6 High‐dose (oral or…
Analysis 6.19
Comparison 6 High‐dose (oral or IV) versus standard‐dose ibuprofen (oral or IV), Outcome…
Analysis 7.1
Comparison 7 Early versus expectant…
Analysis 7.1
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 1 Days on…
Analysis 7.2
Comparison 7 Early versus expectant…
Analysis 7.2
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 2 Days on…
Analysis 7.3
Comparison 7 Early versus expectant…
Analysis 7.3
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 3 Days on…
Analysis 7.4
Comparison 7 Early versus expectant…
Analysis 7.4
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 4 Days on…
Analysis 7.5
Comparison 7 Early versus expectant…
Analysis 7.5
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 5 Chronic lung…
Analysis 7.6
Comparison 7 Early versus expectant…
Analysis 7.6
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 6 Mortality or…
Analysis 7.7
Comparison 7 Early versus expectant…
Analysis 7.7
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 7 Mortality during…
Analysis 7.8
Comparison 7 Early versus expectant…
Analysis 7.8
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 8 Pneumothorax.
Analysis 7.9
Comparison 7 Early versus expectant…
Analysis 7.9
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 9 Intraventricular haemorrhage…
Analysis 7.10
Comparison 7 Early versus expectant…
Analysis 7.10
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 10 Periventricular leukomalacia.
Analysis 7.11
Comparison 7 Early versus expectant…
Analysis 7.11
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 11 Necrotising enterocolitis…
Analysis 7.12
Comparison 7 Early versus expectant…
Analysis 7.12
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 12 Intestinal perforation.
Analysis 7.13
Comparison 7 Early versus expectant…
Analysis 7.13
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 13 Sepsis.
Analysis 7.14
Comparison 7 Early versus expectant…
Analysis 7.14
Comparison 7 Early versus expectant administration of intravenous ibuprofen, Outcome 14 Retinopathy of…
Analysis 8.1
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.1
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.2
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.2
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.3
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.3
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.4
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.4
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.5
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.5
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.6
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.6
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.7
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.7
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.8
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.8
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.9
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.9
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 9.1
Comparison 9 Continuous infusion of…
Analysis 9.1
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 1…
Analysis 9.2
Comparison 9 Continuous infusion of…
Analysis 9.2
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 2…
Analysis 9.3
Comparison 9 Continuous infusion of…
Analysis 9.3
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 3…
Analysis 9.4
Comparison 9 Continuous infusion of…
Analysis 9.4
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 4…
Analysis 9.5
Comparison 9 Continuous infusion of…
Analysis 9.5
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 5…
Analysis 9.6
Comparison 9 Continuous infusion of…
Analysis 9.6
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 6…
Analysis 9.7
Comparison 9 Continuous infusion of…
Analysis 9.7
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 7…
Analysis 9.8
Comparison 9 Continuous infusion of…
Analysis 9.8
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 8…
Analysis 9.9
Comparison 9 Continuous infusion of…
Analysis 9.9
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 9…
Analysis 9.10
Comparison 9 Continuous infusion of…
Analysis 9.10
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 10…
Analysis 9.11
Comparison 9 Continuous infusion of…
Analysis 9.11
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 11…
Analysis 9.12
Comparison 9 Continuous infusion of…
Analysis 9.12
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 12…
Analysis 9.13
Comparison 9 Continuous infusion of…
Analysis 9.13
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 13…
Analysis 9.14
Comparison 9 Continuous infusion of…
Analysis 9.14
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 14…
Analysis 9.15
Comparison 9 Continuous infusion of…
Analysis 9.15
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 15…
Analysis 10.1
Comparison 10 Rectal ibuprofen versus…
Analysis 10.1
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 1 Failure to close a…
Analysis 10.2
Comparison 10 Rectal ibuprofen versus…
Analysis 10.2
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 2 Need for surgical ligation.
Analysis 10.3
Comparison 10 Rectal ibuprofen versus…
Analysis 10.3
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 3 Plasma creatinine (µmol/L.
Analysis 10.4
Comparison 10 Rectal ibuprofen versus…
Analysis 10.4
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 4 Plasma bilirubin (µmol/L) after…
Analysis 10.5
Comparison 10 Rectal ibuprofen versus…
Analysis 10.5
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 5 Urine output (mL/kg/hr) after…
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2015 Feb 18;(2):CD003481. doi: 10.1002/14651858.CD003481.pub6. Cochrane Database Syst Rev. 2015. PMID: 25692606 Updated. Review.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Feb 11;2(2):CD003481. doi: 10.1002/14651858.CD003481.pub8. Cochrane Database Syst Rev. 2020. PMID: 32045960 Free PMC article.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2015 Feb 18;(2):CD003481. doi: 10.1002/14651858.CD003481.pub6. Cochrane Database Syst Rev. 2015. PMID: 25692606 Updated. Review.
- Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants.Ohlsson A, Walia R, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD003481. doi: 10.1002/14651858.CD003481.pub5. Cochrane Database Syst Rev. 2013. PMID: 23633310 Updated. Review.
- Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants.Ohlsson A, Shah SS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Jan 27;1(1):CD004213. doi: 10.1002/14651858.CD004213.pub5. Cochrane Database Syst Rev. 2020. PMID: 31985838 Free PMC article.
- Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.Ohlsson A, Shah PS. Ohlsson A, et al. Cochrane Database Syst Rev. 2020 Jan 27;1(1):CD010061. doi: 10.1002/14651858.CD010061.pub4. Cochrane Database Syst Rev. 2020. PMID: 31985831 Free PMC article. Updated.
- Comparative Effectiveness of Surgical Ligation and Catheter Closure of Patent Ductus Arteriosus in Preterm Infants.Tabb C Jr, Aggarwal S, Bajaj M, Natarajan G. Tabb C Jr, et al. Pediatr Cardiol. 2023 Jun 14. doi: 10.1007/s00246-023-03199-6. Online ahead of print. Pediatr Cardiol. 2023. PMID: 37316609
- Perinatal origins of bronchopulmonary dysplasia-deciphering normal and impaired lung development cell by cell.Mižíková I, Thébaud B. Mižíková I, et al. Mol Cell Pediatr. 2023 Apr 18;10(1):4. doi: 10.1186/s40348-023-00158-2. Mol Cell Pediatr. 2023. PMID: 37072570 Free PMC article. Review.
- Association between endotypes of prematurity and pharmacological closure of patent ductus arteriosus: A systematic review and meta-analysis.Gonzalez-Luis GE, Borges-Lujan M, Villamor E. Gonzalez-Luis GE, et al. Front Pediatr. 2023 Mar 3;11:1078506. doi: 10.3389/fped.2023.1078506. eCollection 2023. Front Pediatr. 2023. PMID: 36937978 Free PMC article.
- Vascular and pulmonary effects of ibuprofen on neonatal lung development.Chen X, Han D, Wang X, Huang X, Huang Z, Liu Y, Zhong J, Walther FJ, Yang C, Wagenaar GTM. Chen X, et al. Respir Res. 2023 Feb 2;24(1):39. doi: 10.1186/s12931-023-02342-4. Respir Res. 2023. PMID: 36732726 Free PMC article.
- Impact of patent ductus arteriosus shunt size and duration on risk of death or severe respiratory morbidity in preterm infants born in China.Deng Y, Zhang H, Zhao Z, Du J, Bai R, McNamara PJ. Deng Y, et al. Eur J Pediatr. 2022 Aug;181(8):3131-3140. doi: 10.1007/s00431-022-04549-x. Epub 2022 Jul 15. Eur J Pediatr. 2022. PMID: 35838780 Free PMC article.
- Meta-Analysis
- Review
- Systematic Review
- Administration, Oral
- Cyclooxygenase Inhibitors / adverse effects
- Cyclooxygenase Inhibitors / therapeutic use*
- Ductus Arteriosus, Patent / drug therapy*
- Enterocolitis, Necrotizing / prevention & control
- Humans
- Ibuprofen / adverse effects
- Ibuprofen / therapeutic use*
- Indomethacin / adverse effects
- Indomethacin / therapeutic use
- Infant, Low Birth Weight*
- Infant, Newborn
- Infant, Premature*
- Injections, Intravenous
- Randomized Controlled Trials as Topic
- Treatment Failure
- Cyclooxygenase Inhibitors
- Ibuprofen
- Indomethacin
- Full Text Sources
- Other Literature Sources
- Medical
- Miscellaneous
![Analysis 6.17](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-17.jpg)
![Analysis 6.18](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-18.jpg)
![Analysis 6.19](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-006-19.jpg)
![Analysis 7.1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-007-01.jpg)
![Analysis 7.2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-007-02.jpg)
![Analysis 7.3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-007-03.jpg)
![Analysis 7.4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-007-04.jpg)
![Analysis 7.5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-007-05.jpg)
![Analysis 7.6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-007-06.jpg)
![Analysis 7.7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-007-07.jpg)
![Analysis 7.8](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-007-08.jpg)
![Analysis 7.9](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-007-09.jpg)
![Analysis 7.10](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-007-10.jpg)
![Analysis 7.11](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-007-11.jpg)
![Analysis 7.12](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-007-12.jpg)
![Analysis 7.13](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-007-13.jpg)
![Analysis 7.14](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-007-14.jpg)
![Analysis 8.1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-008-01.jpg)
![Analysis 8.2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-008-02.jpg)
![Analysis 8.3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-008-03.jpg)
![Analysis 8.4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-008-04.jpg)
![Analysis 8.5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-008-05.jpg)
![Analysis 8.6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-008-06.jpg)
![Analysis 8.7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-008-07.jpg)
![Analysis 8.8](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-008-08.jpg)
![Analysis 8.9](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-008-09.jpg)
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.10
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous…
Analysis 8.11
Comparison 8 Echocardiographically (ECHO)‐guided intravenous ibuprofen treatment versus standard intravenous ibuprofen treatment, Outcome…
Analysis 9.1
Comparison 9 Continuous infusion of…
Analysis 9.1
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 1…
Analysis 9.2
Comparison 9 Continuous infusion of…
Analysis 9.2
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 2…
Analysis 9.3
Comparison 9 Continuous infusion of…
Analysis 9.3
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 3…
Analysis 9.4
Comparison 9 Continuous infusion of…
Analysis 9.4
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 4…
Analysis 9.5
Comparison 9 Continuous infusion of…
Analysis 9.5
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 5…
Analysis 9.6
Comparison 9 Continuous infusion of…
Analysis 9.6
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 6…
Analysis 9.7
Comparison 9 Continuous infusion of…
Analysis 9.7
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 7…
Analysis 9.8
Comparison 9 Continuous infusion of…
Analysis 9.8
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 8…
Analysis 9.9
Comparison 9 Continuous infusion of…
Analysis 9.9
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 9…
Analysis 9.10
Comparison 9 Continuous infusion of…
Analysis 9.10
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 10…
Analysis 9.11
Comparison 9 Continuous infusion of…
Analysis 9.11
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 11…
Analysis 9.12
Comparison 9 Continuous infusion of…
Analysis 9.12
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 12…
Analysis 9.13
Comparison 9 Continuous infusion of…
Analysis 9.13
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 13…
Analysis 9.14
Comparison 9 Continuous infusion of…
Analysis 9.14
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 14…
Analysis 9.15
Comparison 9 Continuous infusion of…
Analysis 9.15
Comparison 9 Continuous infusion of ibuprofen versus intermittent boluses of ibuprofen, Outcome 15…
Analysis 10.1
Comparison 10 Rectal ibuprofen versus…
Analysis 10.1
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 1 Failure to close a…
Analysis 10.2
Comparison 10 Rectal ibuprofen versus…
Analysis 10.2
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 2 Need for surgical ligation.
Analysis 10.3
Comparison 10 Rectal ibuprofen versus…
Analysis 10.3
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 3 Plasma creatinine (µmol/L.
Analysis 10.4
Comparison 10 Rectal ibuprofen versus…
Analysis 10.4
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 4 Plasma bilirubin (µmol/L) after…
Analysis 10.5
Comparison 10 Rectal ibuprofen versus…
Analysis 10.5
Comparison 10 Rectal ibuprofen versus oral ibuprofen, Outcome 5 Urine output (mL/kg/hr) after…
![Analysis 8.10](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-008-10.jpg)
![Analysis 8.11](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-008-11.jpg)
![Analysis 9.1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-009-01.jpg)
![Analysis 9.2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-009-02.jpg)
![Analysis 9.3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-009-03.jpg)
![Analysis 9.4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-009-04.jpg)
![Analysis 9.5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-009-05.jpg)
![Analysis 9.6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-009-06.jpg)
![Analysis 9.7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-009-07.jpg)
![Analysis 9.8](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-009-08.jpg)
![Analysis 9.9](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-009-09.jpg)
![Analysis 9.10](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-009-10.jpg)
![Analysis 9.11](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-009-11.jpg)
![Analysis 9.12](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-009-12.jpg)
![Analysis 9.13](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-009-13.jpg)
![Analysis 9.14](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-009-14.jpg)
![Analysis 9.15](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-009-15.jpg)
![Analysis 10.1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-010-01.jpg)
![Analysis 10.2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-010-02.jpg)
![Analysis 10.3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-010-03.jpg)
![Analysis 10.4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-010-04.jpg)
![Analysis 10.5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6513618/bin/nCD003481-CMP-010-05.jpg)
Source: PubMed