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Clinical Efficacy of Antivet Versus Phosphoric Acid and Hydrochloric Acid in Microabrasion

2026年7月14日 更新者:Esraa Esmeail Hussien、Misr University for Science and Technology

Clinical Efficacy of Antivet Versus Phosphoric Acid and Hydrochloric Acid in Microabrasion Technique for Treatment of Stained Teeth: Randomized Clinical Trial

This clinical trial will be conducted to assess the clinical efficacy of using Antivet cleaning enamel solution or hydrochloric acid and phosphoric acid in microabrasion technique for mild to moderate intrinsic stained teeth.

調査の概要

状態

募集

条件

介入・治療

詳細な説明

  • Oral prophylaxis will be provided by scaling and polishing of discolored teeth. Next, pre-operative color photographs of the teeth will be taken using a digital camera at a pre-established, standardized setting and focal length.
  • tooth/teeth will be isolated with a Nic Tone dental dam and vaseline will be placed on gingival sulcus before placing dental dam.
  • patient will be seated at a 45 degree angle.
  • 5 drops of Antivet will be placed in the plastic mixing well that comes with the kit.Apply the ANTIVET solution over the tooth's surface using a well condensed cotton pellet (approximately a 3 mm diameter), the cotton pellet will be holded with the pliers that were provided in the kit and the pellet will be rubbed onto the surface in a sweeping motion from cervical to incisal.
  • When the cotton pellet is pigmented by the tooth's staining, a new one will be used, the pellet will be saturated with the solution and the procedure will be repeated, this process will be repeated until the stain is removed. This process may take about 1 to 5 minutes per tooth. It should take no longer than 15 minutes from the moment the solution contacts the tooth's surface.
  • The tooth must not be dry at any given moment, otherwise the Antivet solution will not work properly.
  • Before completing treatment, the last application will be applied with a new pellet and sweeping movements will be made from the distal surface towards the midline of the tooth.
  • Once the tooth surface is free of stains, A dry cotton pellet or gauze will be used to remove any excess solution on the enamel.
  • In a separate mixing well the NEUTRALIZING SOLUTION will be dispensed, the solution will be applied onto the tooth surface using a brush or microbrush and let it sit for 2 minutes. It is of utmost importance that the neutralizing solution will be applied completely up to the gingival margin.
  • the dental dam will not removed until you the process has been completed with the neautralizing agent.
  • The last step will be rinsing with water.
  • postoperative photographs will be taken after one hour with the same condition as mentioned above.
  • Pre- and post-operative photographs of each patient will be shown to clinician other than operator who is unaware of the modality of treatment given to each group of patients. Then he will evaluate a score for improvement in appearance using a visual analog scale.

    ►B. Comparator Group 1

  • Oral prophylaxis will be provided by scaling and polishing of discolored teeth. Next, pre-operative color photographs of the teeth will be taken using a digital camera at a pre-established, standardized setting and focal length.
  • tooth/teeth will be isolated with a Nic Tone dental dam and vaseline will be placed on gingival sulcus before placing dental dam.
  • patient will be seated at a 45 degree angle.
  • Equal quantities from phosphoric acid 37% and aluminium oxid 50 micron will be mixed, thick mix will be applied on the affected tooth/teeth and will be rubbed with a rubber cup in a low-speed contra-angle handpiece for 60 seconds of each application. Every patient will be received the entire microabrasion treatment in a single appointment with a maximum of 6 applications. At the end of the treatment, MI Paste (GC America) will be applied for four minutes and then rubber dam will be removed.
  • Patients will be instructed not to drink any colored drinks like tea, coffee and cola for 72 hours.
  • postoperative photographs will be taken after one hour with the same condition as mentioned above.
  • Pre- and post-operative photographs of each patient will be shown to clinician other than operator who is unaware of the modality of treatment given to each group of patients. Then he will evaluate a score for improvement in appearance using a visual analog scale.

C. Comparator Group 2

  • Oral prophylaxis will be provided by scaling and polishing of discolored teeth. Next, pre-operative color photographs of the teeth will be taken using a digital camera at a pre-established, standardized setting and focal length.
  • tooth/teeth will be isolated with a Nic Tone dental dam and vaseline will be placed on gingival sulcus before placing dental dam.
  • patient will be seated at a 45 degree angle.

    • Microabrasion will be conducted using Opalustre (Ultradent Products Inc, South Jordan, UT, USA) will be applied onto the stained areas of the teeth. The microabrasion technique will be performed according to the manufacturer's instructions.
    • A fine-grit diamond abrasive bur will be used initially for 5 to 10 seconds on the stained areas of the tooth to help the microabrasion slurry penetrate into the enamel. This will be followed by drying of the teeth and application of the microabrasion slurry of approximately 1- to 3-mm thickness onto the stained regions of the teeth using rubber prophy cups (OpalCups, Ultradent Products Inc) for 60 seconds.
    • The teeth will be rinsed with water between slurry applications. Depending on the stain reduction, microabrasion will be repeated up to six times during the same appointment to achieve the desired result.
    • At the end of the treatment, MI Paste (GC America) will be applied for four minutes and then rubber dam will be removed.
    • Patients will be instructed not to drink any colored drinks like tea, coffee and cola for 72 hours.
    • postoperative photographs will be taken after one hour with the same condition as mentioned above.
    • Pre- and post-operative photographs of each patient will be shown to clinician other than operator who is unaware of the modality of treatment given to each group of patients. Then he will evaluate a score for improvement in appearance using a visual analog scale.

研究の種類

介入

入学 (推定)

60

段階

  • フェーズ 1

連絡先と場所

このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。

研究連絡先

  • 名前:Esraa Esmeail Hussien EEH Lecturer, phd holder
  • 電話番号:0201111103836
  • メール:dr.esraaism@gmail.com

研究連絡先のバックアップ

研究場所

    • Cairo Governorate
      • Badr、Cairo Governorate、エジプト、11829
        • 募集
        • Egyptian Russian University
        • コンタクト:
          • Esraa Esmeail Hussien EEH lecturer, phd holder
          • 電話番号:+201111103836
          • メール:dr.esraaism@gmail.com

参加基準

研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。

適格基準

就学可能な年齢

  • 子
  • 大人

健康ボランティアの受け入れ

いいえ

説明

  1. Eligibility Criteria of participants:

    Inclusion Criteria:

    • Patients with moderate to mild stained teeth.
    • 16-50 years.
    • Males or Females.
    • Co-operative patients approving to participate in the study.

    Exclusion Criteria:

    • High caries index with poor oral hygiene.
    • Severe medical complications.
    • Pregnancy.
    • Xerostomia.
    • Lack of compliance.
    • Smokers
  2. Eligibility Criteria of teeth:

Inclusion Criteria of teeth:

  • Anterior teeth.
  • Mild to moderate intrinsic or extrinsic stains.
  • Vital and non-sensitive anterior teeth.

Exclusion criteria of the teeth:

  • pitted enamel.
  • carious teeth.
  • Deep lesions.
  • Severe periodontal problems.
  • Previous treatment for the stained teeth

研究計画

このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。

研究はどのように設計されていますか?

デザインの詳細

  • 主な目的:処理
  • 割り当て:ランダム化
  • 介入モデル:並列代入
  • マスキング:トリプル

武器と介入

参加者グループ / アーム
介入・治療
アクティブコンパレータ:phosphoric acid 37% and aluminium oxid 50 microns
Microabrasion technique could be considered as the first treatment option when trying to improve the esthetics of teeth that present with mild or moderate intrinsic stains as it is a simple, safe, atraumatic, minimally invasive single visit procedure with high success rate
● Equal quantities from phosphoric acid 37% and aluminium oxid 50 microns will be mixed, thick mix will be applied on the affected tooth/teeth and will be rubbed with a rubber cup in a low-speed contra-angle handpiece for 60 seconds of each application. Every patient will be received the entire microabrasion treatment in a single appointment with a maximum of 6 applications.
アクティブコンパレータ:Opalustre™
a mixture of 37% phosphoric acid gel in extra fine grain pumice or 18% hydrochloric acid in pumice or 6.6% and 10% hydrochloric acid with silica carbide particles, with rubber cup in slow rotating motion to the areas of discoloration or white opacities. Another advantage of microabrasion technique is that it leaves the treated enamel surface as highly polished which minimizes the cariogenic bacteria colonization and render it more resistant to demineralization

technique involves employing a mixture 6.6% hydrochloric acid with silica carbide particles, with rubber cup in slow rotating motion to the areas of discoloration or white opacities for 60 seconds. The teeth will be rinsed with water between slurry applications. Depending on the stain reduction, microabrasion will be repeated up to six times during the same appointment to achieve the desired result.

.

実験的:Antivet
The Antivet Kit solution is specially formulated to eliminate stains on the enamel surface caused by dental fluorosis or any other external factor.The tooth's surface is exposed to an acid solution by ionization by the fluoride absorbed in the apatite crystals (stains). This reaction allows for the fluoride ions to separate from the fluoride ions in the apatite crystals, forming soluble salts that are easily removed from the tooth enamel surface. Once the stains are removed, a calcium hydroxide solution is applied to neutralize the residual acidic solution left on the tooth surface. Lastly, the tooth is rinsed with water.Acid Base (Antivet): It is hydrofluoric acid at a 21% concentration stabilized by an organic tricarboxylic acid, with a controlled pH of <3, necessary to react with the fluoride ions to form soluble salts. The organic and inorganic ions are extracted from within the fluorapatite crystals through this ionization process which essentially allows the enamel surface to be
specially formulated to eliminate stains on the enamel surface caused by dental fluorosis or any other external factor.The tooth's surface is exposed to an acid solution by ionization by the fluoride absorbed in the apatite crystals (stains). This reaction allows for the fluoride ions to separate from the fluoride ions in the apatite crystals, forming soluble salts that are easily removed from the tooth enamel surface. Once the stains are removed, a calcium hydroxide solution is applied to neutralize the residual acidic solution left on the tooth surface. Lastly, the tooth is rinsed with water.Acid Base (Antivet): It is hydrofluoric acid at a 21% concentration stabilized by an organic tricarboxylic acid, with a controlled pH of <3, necessary to react with the fluoride ions to form soluble salts. The organic and inorganic ions are extracted from within the fluorapatite crystals through this ionization process which essentially allows the enamel surface to be cleansed without damaging it

この研究は何を測定していますか?

主要な結果の測定

結果測定
メジャーの説明
時間枠
Clinical performance
時間枠:three months
visual analog scale using scoring system
three months

協力者と研究者

ここでは、この調査に関係する人々や組織を見つけることができます。

スポンサー

捜査官

  • スタディディレクター:Esraa Esmeail Hussien EEH Elhaddad, PHD、Misr University for Science and Technology

出版物と役立つリンク

研究に関する情報を入力する責任者は、自発的にこれらの出版物を提供します。これらは、研究に関連するあらゆるものに関するものである可能性があります。

研究記録日

これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。

主要日程の研究

研究開始 (実際)

2026年1月10日

一次修了 (推定)

2026年7月10日

研究の完了 (推定)

2026年10月1日

試験登録日

最初に提出

2026年7月10日

QC基準を満たした最初の提出物

2026年7月14日

最初の投稿 (実際)

2026年7月16日

学習記録の更新

投稿された最後の更新 (実際)

2026年7月16日

QC基準を満たした最後の更新が送信されました

2026年7月14日

最終確認日

2026年7月1日

詳しくは

本研究に関する用語

その他の研究ID番号

  • 49

個々の参加者データ (IPD) の計画

個々の参加者データ (IPD) を共有する予定はありますか?

いいえ

IPD プランの説明

will not be shared except with authors only

医薬品およびデバイス情報、研究文書

米国FDA規制医薬品の研究

はい

米国FDA規制機器製品の研究

いいえ

米国で製造され、米国から輸出された製品。

はい

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