Effect of Turmeric Extract With Black Pepper on Tooth Pain After Root Canal Treatment
EFFECT OF PREOPERATIVE ORAL CURCUMIN WITH PIPERINE ON POSTOPERATIVE PAIN FOLLOWING SINGLE-VISIT PRIMARY ROOT CANAL TREATMENT IN MANDIBULAR MOLARS WITH SYMPTOMATIC IRREVERSIBLE PULPITIS
The purpose of this study is to evaluate the effectiveness of taking a turmeric extract supplement before a root canal to help reduce tooth pain after the procedure.
Patients diagnosed with symptomatic irreversible pulpitis (severe, irreversible tooth nerve inflammation causing significant pain) in their lower back teeth (mandibular molars) will participate in the study. All participants will receive a standard, single visit root canal treatment. Before the procedure begins, one group of patients will receive an oral supplement containing curcumin (the active compound in turmeric) combined with piperine (black pepper extract, which helps the body absorb curcumin). Another group will receive a placebo (an inactive substance).
The investigators will compare the levels of postoperative pain between the two groups in the days following the root canal treatment to see if the turmeric extract supplement successfully provides better pain relief.
調査の概要
状態
状態
条件
条件
介入・治療
介入・治療
研究の種類
研究の種類
入学 (推定)
入学
段階
段階
- 適用できない
連絡先と場所
研究連絡先
研究連絡先
- 名前：Zonash Rashid, BDS
- 電話番号：00923208899790
- メール：zonashrashid005@gmail.com
研究場所
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Punjab Province
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Rawalpindi、Punjab Province、パキスタン
- Watim Medical & Dental College
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コンタクト：
- Zonash Rashid, BDS
- 電話番号：00923208899790
- メール：zonashrashid005@gmail.com
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コンタクト：
-
主任研究者：
- Zonash Rashid, BDS
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-
参加基準
適格基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Patients aged 18 to 60 years.
- Mature permanent mandibular first or second molar with clinical diagnosis of symptomatic irreversible pulpitis.
- Moderate to severe preoperative pain on the VAS.
- Willingness to provide written informed consent and complete the 48-hour pain record.
Exclusion Criteria:
- Pregnancy or lactation.
- Known hypersensitivity to curcumin, turmeric or capsule components.
- Analgesic or anti-inflammatory medication within 12 hours before treatment.
- Anticoagulant or antiplatelet therapy, clinically relevant bleeding disorder, or significant hepatic, renal or gastrointestinal disease.
- Acute apical abscess, swelling, sinus tract or radiographic apical periodontitis.
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：ダブル
アーム数
武器と介入
参加者グループ / アーム参加者グループ / アーム |
介入・治療介入・治療 |
|---|---|
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プラセボコンパレーター：プラセボ群
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An inactive capsule manufactured to be completely identical in appearance, color, size, and weight to the active curcumin capsule, administered preoperatively. |
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実験的：Curcumin Arm
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An oral administration consisting of curcumin paired with piperine, administered preoperatively to enhance bioavailability prior to the root canal treatment. |
この研究は何を測定していますか？
主要な結果の測定
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Postoperative Pain Score
時間枠：24 Hours
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Postoperative pain will be assessed using a 0-100 mm Visual Analog Scale (VAS), where a score of 0 mm represents "no pain" and a score of 100 mm represents "the worst possible pain." Patients will mark their pain level on a 100 mm line, and higher scores indicate a greater intensity of postoperative pain. |
24 Hours
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二次結果の測定
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Rescue Analgesic Consumption
時間枠：Up to 48 hours post-treatment
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The total amount of rescue medication taken by the participants will be recorded. Patients will be instructed to take Ibuprofen as needed for severe postoperative pain. The outcome will be measured as the average number of Ibuprofen tablets consumed per participant during the follow up period. A lower tablet count indicates better pain management by the preoperative intervention. |
Up to 48 hours post-treatment
|
協力者と研究者
出版物と役立つリンク
一般刊行物
- Pak JG, White SN. Pain prevalence and severity before, during, and after root canal treatment: a systematic review. J Endod. 2011 Apr;37(4):429-38. doi: 10.1016/j.joen.2010.12.016.
- Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6. doi: 10.1055/s-2006-957450.
- Lopresti AL, Smith SJ, Hood SD, et al. Efficacy of curcumin plus piperine co-supplementation in pain management: a systematic review and meta-analysis. Front Nutr. 2024;11:1348329.
- Singhal R, Agarwal A, Rastogi P, et al. Current applications of Curcuma longa in dentistry: a scoping review of literature published after 2019. BMC Oral Health. 2026;26(1):45-58.
- Reddy MS, Ramachandra SS, Shetty SR, Khazi SS, Ur Rahman Tippu MS, Narayanan LA, Shetty RM, Azim SA, Ramana VV, Al-Bayati SAAF, Razooki A, Fouad NN. Analgesic Efficacy of Phytotherapeutic Agents in Dental Pain Management: A Systematic Review. Int J Dent. 2025 Nov 20;2025:5614623. doi: 10.1155/ijod/5614623. eCollection 2025.
- Bucevic Popovic V, Karahmet Farhat E, Banjari I, Jelicic Kadic A, Puljak L. Bioavailability of Oral Curcumin in Systematic Reviews: A Methodological Study. Pharmaceuticals (Basel). 2024 Jan 28;17(2):164. doi: 10.3390/ph17020164.
- Di Cosola M, Cazzolla AP, Charitos IA, et al. The role of curcumin in oral health and diseases: a systematic review. Dent J (Basel). 2024;12(5):132.
- Hashemi N, Shahsavari F, Mokhtari H, et al. Analgesic effect of a kind of herbal medicine, compared to ibuprofen on post-endodontic pain: a randomized clinical trial study. J Mashhad Dent Sch. 2023;47(3):337-345.
- Abdelnaby MS, Eid GEM, El Nabarawi MA. The effect of premedication with curcumin on post-operative pain in single visit endodontic treatment of acute pulpitis in mandibular molars: a randomized controlled trial. J Dent Oral Epidemiol. 2021;1(3):1-11.
- Khan MK, Khan IA, Liaquat A. Therapeutic Potential of Curcumin with and without Strengthening Exercises in Improving Rheumatoid Arthritis. J Coll Physicians Surg Pak. 2022 Dec;32(12):1640-1643. doi: 10.29271/jcpsp.2022.12.1640.
- Singla R, Gupta C, Gill GS, Jain N, Arora S, Algarni YA, Kader MA, Cicciu M, Minervini G. Effect of Curcuma longa (Turmeric), as an intra-canal medicament, on inter-appointment endodontic pain in patients with symptomatic irreversible pulpitis: A randomized controlled clinical trial. Heliyon. 2024 Jun 28;10(14):e33797. doi: 10.1016/j.heliyon.2024.e33797. eCollection 2024 Jul 30.
- Basu P, Maier C, Basu A. Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review. Int J Mol Sci. 2021 Apr 28;22(9):4666. doi: 10.3390/ijms22094666.
- De Geus JL, Wambier LM, Boing TF, Loguercio AD, Reis A. Effects of Ibuprofen Compared to Other Premedication Drugs on the Risk and Intensity of Postendodontic Pain: A Systematic Review. Eur Endod J. 2018 Oct 9;3(3):123-133. doi: 10.14744/eej.2018.83803. eCollection 2018.
- Elkhadem A, Ezzat K, Ramadan M, AbdelGhaffar S, Khamis D, Hassan A, Abdel-Mawgoud A, Mamdouh A, AbouZeid M, Amin S. The effect of preoperative oral administration of prednisolone on postoperative pain in patients with symptomatic irreversible pulpitis: a single-centre randomized controlled trial. Int Endod J. 2018 Apr;51 Suppl 3:e189-e196. doi: 10.1111/iej.12795. Epub 2017 Jul 4.
研究記録日
主要日程の研究
研究開始 (推定)
研究開始
一次修了 (推定)
一次修了
研究の完了 (推定)
研究の完了
試験登録日
最初に提出
最初に提出
QC基準を満たした最初の提出物
QC基準を満たした最初の提出物
最初の投稿 (実際)
最初の投稿
学習記録の更新
投稿された最後の更新 (実際)
投稿された最後の更新
QC基準を満たした最後の更新が送信されました
QC基準を満たした最後の更新が送信されました
最終確認日
最終確認日
詳しくは
本研究に関する用語
追加の関連 MeSH 用語
その他の研究ID番号
その他の研究ID番号
- WM&DCR/R&D(IERB)/2026/273
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
IPD プランの説明
he individual participant data will not be shared outside the host institution to maintain patient confidentiality and comply with institutional privacy protocols.
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
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