Motor Cortex Reward Signaling in Parkinson Disease
Background:
The brain releases signals to mark rewards for certain behavior. Some medications for Parkinson disease (PD) can cause some patients to engage in compulsive behavior, possibly because the medications affect this reward system.
By using transcranial magnetic stimulation (TMS), researchers can study brain activity when an individual receives a reward.
Objectives:
To learn how the brains of people with PD behave when rewarded.
To learn whether two common Parkinson medications (levodopa and pramipexole) change this behavior.
To compare reward signals in the brains of healthy volunteers with reward signals in the brains of people with PD.
Eligibility:
Women between 50 and 80 years of age and men between 45 and 80 years of age.
Participants will be divided into healthy volunteers and volunteers who have mild to moderate PD.
Design:
Prescreening will consist of a neurological examination and a series of questions about gambling habits and drug and alcohol use.
Participation in a TMS study involving a computer game simulation of a slot machine:
- Before the simulation, participants will receive TMS to establish a baseline response rate.
- During the simulation, participants will play a game in which they will receive real money.
TMS will be administered to each patient under three different conditions:
- TMS administered when patients have not taken any Parkinson medication.
- TMS administered after patients have taken levodopa.
- TMS administered after patients have taken pramipexole....
調査の概要
状態
条件
詳細な説明
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Maryland
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Bethesda、Maryland、アメリカ、20892
- National Institutes of Health Clinical Center, 9000 Rockville Pike
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
- INCLUSION CRITERIA:
HEALTHY SUBJECTS:
-Age 45-70 years
PATIENTS:
- Mild-moderate disease (Hoehn and Yahr stage 1-2).
- Age 45-70 yrs
EXCLUSION CRITERIA:
- Pre-menopausal status in women: Preliminary data in healthy, cycling women suggests that the variation in paired-pulse inhibition caused by the menstrual cycle may obscure the change in the response induced by the behavioral task.
- Significant neurological or psychiatric history other than PD
- Exposure to DA agonists within a month of study
- History of habitual gambling, defined as either visiting casinos more than once per month or playing cards for money more than once per week or gambling over the internet more than once per month
- Habitual consumption of more than two drinks a day, marijuana more than once a week or any other illicit drug use within the last three months
- Significant abnormality on neurological examination other than PD related signs
- Metal in the cranial cavity or eye, pacemaker, implanted pumps or stimulators
- Use of non-PD related medications affecting the DA system, such as phenothiazine antihistamines (promethazine), antiemetics or decongestants in the last month
研究計画
研究はどのように設計されていますか?
デザインの詳細
協力者と研究者
出版物と役立つリンク
一般刊行物
- Avanzi M, Uber E, Bonfa F. Pathological gambling in two patients on dopamine replacement therapy for Parkinson's disease. Neurol Sci. 2004 Jun;25(2):98-101. doi: 10.1007/s10072-004-0238-z.
- Cohen MX, Young J, Baek JM, Kessler C, Ranganath C. Individual differences in extraversion and dopamine genetics predict neural reward responses. Brain Res Cogn Brain Res. 2005 Dec;25(3):851-61. doi: 10.1016/j.cogbrainres.2005.09.018. Epub 2005 Nov 11.
- Strobel A, Spinath FM, Angleitner A, Riemann R, Lesch KP. Lack of association between polymorphisms of the dopamine D4 receptor gene and personality. Neuropsychobiology. 2003;47(1):52-6. doi: 10.1159/000068876.
研究記録日
主要日程の研究
研究開始
研究の完了
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
パーキンソン病の臨床試験
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