Polyunsaturated Fatty Acids in Child Nutrition (PINGU)
Polyunsaturated Fatty Acids in Child Nutrition - A German Multimodal Optimisation Study
Primary objective of this study is to examine the effects of 2 different approaches of dietary strategies to optimise fatty acid composition in complementary food on infant's fatty acid status and its consequences on cognitive and visual development.
Subjects are randomly assigned to one of three groups:
- Rapeseed oil (high in n-3 PUFA and small n-6:n-3 ratio to support endogenous n- 3 LC-PUFA metabolism)
- Fatty fish (preformed n-3 LC-PUFA, especially DHA)
- Corn oil (as control group, high in n-6 PUFA, common in complementary food).
The intervention starts with the beginning of complementary feeding as generally recommended between 4 to 6 months of age and ends at the age of 10 months. For this period of time subjects of all groups receive commercial vegetable-potato-meat-meals as part of complementary food which only differs in the fatty acid composition.
調査の概要
詳細な説明
A well balanced supply of polyunsaturated fatty acids, in particular the omega-3 long chain docosahexaenoic acid (DHA), in early childhood is essential for children's cognitive and visual development. DHA can either be supplied preformed in the diet (e.g. via fatty fish) or synthesised by conversion of its essential precursor alpha-linolenic acid (e.g. via rapeseed oil). The study examines the effect of two different approaches to optimise infants´ fatty acid status.
The study sample consists of healthy newborns and their mothers (3 x 57 infants according to a priori power calculation) who are enrolled in delivery hospitals in the region of Dortmund, Germany. In total, the individual study program covers the first 10 months of infant's life. Biomarkers of fatty acid status from the mother are collected 8 weeks pp for the estimation of pre- and perinatal fatty acid supply. Additionally, information on maternal diet during pregnancy and after delivery is assessed. The intervention covers the period of complementary feeding (from 4 to 6 months of age until 10 months of age). In all groups the specific study food is given 5 to 7 times a week, whereas 2 of these are fish meals in the fatty fish group. At the age of 4 and 10 months blood samples are collected from the infants to examine the effect on blood fatty acid status. Parameters of visual and cognitive development are also assessed at the age of 4 and 10 months using VEP examinations and Bayley scales. Infants´ dietary intake is assessed from the end of the 2 months until 10 months of age using continuous weighed dietary records.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Dortmund、ドイツ、44225
- Research Institute of Child Nutrition
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- a term healthy newborn infant ( birth weight > 2500 g, gestational age > 37 weeks
- German speaking mother
- the intention of the mother to breast-feed the children and to feed study menus at least 5 times per week beginning in the fifth to seventh month of life.
Exclusion Criteria:
- preterm children
- twins
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 主な目的:防止
- 割り当て:ランダム化
- 介入モデル:並列代入
- マスキング:4倍
武器と介入
参加者グループ / アーム |
介入・治療 |
---|---|
実験的:Rapeseed oil
Study group receive commercial vegetable-potato-meat-meals containing rapeseed oil as part of complementary food
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Groups receive commercial vegetable-potato-meat-meals as part of complementary food which differs in the fatty acid composition
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実験的:Fatty fish
Study group receive 2 times per week a vegetable-potato-meat-meals as part of complementary food.
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Groups receive commercial vegetable-potato-meat-meals as part of complementary food which differs in the fatty acid composition
|
アクティブコンパレータ:Corn oil
Study group receive commercial vegetable-potato-meat-meals containing corn oil as part of complementary food
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Groups receive commercial vegetable-potato-meat-meals as part of complementary food which differs in the fatty acid composition
|
この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Infants´ fatty acid status
時間枠:10 months after delivery
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Fatty acids (saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids including long-chain polyunsaturated fatty acids) are measured in percent of total fatty acids in erythrocyte membranes, whole plasma, and cheek cells in order to assess the fatty acid composition.
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10 months after delivery
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Infants´ visual development
時間枠:10 months after delivery
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Infants´ visual development is assessed using the visual evoked potentials method.
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10 months after delivery
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Infants´ cognitive development
時間枠:10 months after delivery
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Infants´ cognitive development is assessed using the Bayley II scale.
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10 months after delivery
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Infants´ haemogram
時間枠:10 months after delivery
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10 months after delivery
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Infants´antioxidant status
時間枠:10 months after delivery
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10 months after delivery
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Infants´ body weight
時間枠:10 months after delivery
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10 months after delivery
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Infants´ dietary intake
時間枠:from 2 until 10 months after delivery
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from 2 until 10 months after delivery
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Maternal dietary intake
時間枠:pregnancy and first 2 months post partum
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pregnancy and first 2 months post partum
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Infant's preference for fish
時間枠:10 month after delivery
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10 month after delivery
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Infant's preference for new flavour
時間枠:10 month after delivery
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10 month after delivery
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Parental attitudes about fish and feeding strategies
時間枠:10 months after delivery
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10 months after delivery
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Mother´s fatty acid status
時間枠:2 months after delivery
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Fatty acids (saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids including long-chain polyunsaturated fatty acids) are measured in percent of total fatty acids in erythrocyte membranes, whole plasma, cheek cells, and breast milk in order to assess the fatty acid composition.
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2 months after delivery
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Infants´ body length
時間枠:10 months after delivery
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10 months after delivery
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Infant´s head circumference
時間枠:10 months after delivery
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10 months after delivery
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協力者と研究者
協力者
捜査官
- スタディディレクター:Mathilde Kersting, Professor、Research Institute of Child Nutrition
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- PINGU0911DO
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