Non-invasive Screening of the Status of the Vascular System: Feasibility Test (NISTAS1)
This project is part of the EU funded project NISTAS. NISTAS aims at the development of a new medical device for non-contact, non-invasive screening of the health status of the vascular system of adult subjects. The instrument, called VascuLight, is intended to be deployed at out-patient points-of-care and hospitals, and it provides output parameters related to the PWV as measured at local and/or at regional level.
NISTAS brings together four European SMEs in four different, but complementary, technology areas (JULIGHT, ECLEXYS, EPI-LIGHT, OIP) and links them with five RTD Performers (UNIPV, OSM, CORK UNIVERSITY, Saphyrion, Eudax srl ) to develop new knowledge and a new medical device which will have significant commercial benefits for all of the SME partners.
VascuLight responds to an unmet need in the medical diagnosis practice: the request for a fast and sustainable method for the screening of the health of the vascular system in large series, capable of providing a reliable indicator of the cardiovascular risk of the screened subjects.
The VascuLight idea is founded on a paradigm shift: bringing and adapting to the biomedical field measurement techniques that are to date confined to the industrial environment. NISTAS will develop new non-contact distance/displacement/vibration sensors based on a variant of the well-known and reliable laser triangulation technique.
JUL and UNIPV have carried out proof-of-concept, in-vivo tests of the VascuLight approach to demonstrate that the concept is realistic and attainable. Results have been obtained using Laser Doppler Vibrometry (LDV), a displacement-measuring technique based on the principle of light interference, and an area where both JUL and UNIPV have made important contributions. In the tests it was possible to use TWO small LDV optical heads to simultaneously measure the pulse wave in two points on the carotid spaced by 2.5 cm, allowing for the calculation of the time-delay between the pulse waves, and thus providing a direct local measurement of the PWV.
The aim of the study is to test the implemented contactless optical technique for the measurement of the PWV and the arterial stiffness at the carotid artery level.
To evaluate the validity of the measure method, the investigators will compare Vasculight v1.0 PWV measures with those obtained from e-tracking (echocardiographic method) . The main idea is to compare the distribution of measures (comparable mean and standard deviation) in the same mixed adult population, using the two different methods.
調査の概要
状態
介入・治療
研究の種類
入学 (予想される)
段階
- 適用できない
連絡先と場所
研究連絡先
- 名前:Valentina Favalli, BME
- 電話番号:0039 0382 501487
- メール:v.favalli@smatteo.pv.it
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Age 18-65
Exclusion Criteria:
- Systolic BP >160 mmHg or diastolic BP >100 mmHg
- Treated hypertension
- Diagnosis of type 1 or type 2 diabetes mellitus
- Treated hypercholesterolaemia
- Past or current, symptomatic or proven, coronary artery disease
- Clinical cerebrovascular disease
- Carotid arterial stenosis
- Severe peripheral vascular disease
- Hypertrophic or dilated cardiomyopathy
- Congestive heart failure
- Heart valve disease
- Previous cardiac surgery
- Congenital heart disease
- Other systemic diseases such as cancers, endocrine diseases and autoimmune diseases
- Any regular drug treatment
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 割り当て:なし
- 介入モデル:単一グループの割り当て
- マスキング:なし(オープンラベル)
武器と介入
参加者グループ / アーム |
介入・治療 |
---|---|
実験的:Vasculight prototype zero level
|
Comparative measre of Pulse Wave velocity with both Vasculight prototype and Echocardiographic machine.
|
この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Pulse Wave velocity
時間枠:1 month
|
Bland Altmann test and ROC analysis will be used to compare the 2 methods
|
1 month
|
協力者と研究者
スポンサー
研究記録日
主要日程の研究
研究開始
一次修了 (予想される)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
その他の研究ID番号
- 20140008054
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。