Processing of Music in Alzheimer Patients (MUKU-DEM)
Correlation of Musicality and Cognitive Skills in Persons With Alzheimer´s Disease
調査の概要
詳細な説明
Alzheimer's disease (AD) is the most common cause of dementia accounting for 60-70% of all dementias. In most cases the cause for AD is unknown. The progression of AD is characterized by an advancing decline in cognitive skills and symptoms like impaired learning, memory deficits, language impairment and behavioral disturbances in later stages. The symptoms of AD are caused by cerebral atrophy which is the consequence of multiple pathological processes, including the formation of neurofibrillary tangles at neurites and amyloid plaques in the walls of cerebral blood vessels. AD is a major public health issue and its significance increases as the population grows older.
Music is thought to have preceded the development of spoken language as a form of communication and it has been used for therapeutic purposes in many ways throughout history. In patients with AD, musical memory has been noticed to be well-preserved and constituting a relatively independent part of memory. Music-based neurological rehabilitation provides a mode of treatment, which is free of side effects and can be personalized for patients with dementia.
Aims of this study are to examine how AD affects the structure of various brain areas associated with music processing and to statistically correlate musical cognition with memory performance in patients with AD. Focus is on brain areas associated with musical pleasure like the striatum, superior temporal gyrus, inferior frontal gyrus and areas associated with long-term musical memory like the anterior cingulate gyrus and presupplementary motor area. Hippocampal atrophy serves as a reference of the stage of AD. Our working hypothesis is that musicality correlates with preserved cognitive skills and memory.
Voluntary participants who have been diagnosed with AD are recruited from Turku University Central Hospital. Their musicality is assessed with a short version of Montreal Battery of Evaluation of Amusia which contains listening tasks that test the patients' memory, rhythm recognition and pitch discrimination. In addition, patients are asked to fill an inquiry that maps their use of music and its significance in their daily lives. Voxel-Based Morphometry is applied on MRI images to evaluate atrophy in the hippocampus and entorhinal cortex, which correlate with clinical stages of AD, as well as on the brain areas relevant for processing of music.
研究の種類
入学 (予想される)
連絡先と場所
研究連絡先
- 名前:Seppo Soinila, MD PhD
- 電話番号:+358503463396
- メール:seppo.soinila@tyks.fi
研究連絡先のバックアップ
- 名前:Pavel Zaitsev, B.Sc.
- メール:pavel.p.zaitsev@utu.fi
参加基準
適格基準
就学可能な年齢
- 子
- 大人
- 高齢者
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
Diagnosed Alzheimer´s disease
Exclusion Criteria:
Other neurological comorbidity, substance abuse
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 観測モデル:コホート
- 時間の展望:回顧
この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Montreal Battery of Evaluation of Amusia
時間枠:60 minutes
|
Number of correct answers in three task collections (total 79 tasks)
|
60 minutes
|
Brain atrophy in MRI scans
時間枠:120 minutes
|
Loss of volume in brain regions relevant for music processing and in the hippocampi estimated by voxel-based morphometry
|
120 minutes
|
CERAD (Consortium for Establishing Registry of Alzheimer´s Disease)
時間枠:30 minutes
|
Level of cognitive impairment
|
30 minutes
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Use of music in patient´s daily life
時間枠:30 minutes
|
Validated self-report questionnaire MusEQ in Finnish, Likert scale 1-5 (Vanstone AD et al, Aging Ment Health 2016)
|
30 minutes
|
協力者と研究者
捜査官
- 主任研究者:Seppo Soinila, MD PhD、Turku University Hospital
研究記録日
主要日程の研究
研究開始 (予想される)
一次修了 (予想される)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。