- ICH GCP
- 미국 임상 시험 레지스트리
- 임상시험 NCT04132193
Processing of Music in Alzheimer Patients (MUKU-DEM)
Correlation of Musicality and Cognitive Skills in Persons With Alzheimer´s Disease
연구 개요
상세 설명
Alzheimer's disease (AD) is the most common cause of dementia accounting for 60-70% of all dementias. In most cases the cause for AD is unknown. The progression of AD is characterized by an advancing decline in cognitive skills and symptoms like impaired learning, memory deficits, language impairment and behavioral disturbances in later stages. The symptoms of AD are caused by cerebral atrophy which is the consequence of multiple pathological processes, including the formation of neurofibrillary tangles at neurites and amyloid plaques in the walls of cerebral blood vessels. AD is a major public health issue and its significance increases as the population grows older.
Music is thought to have preceded the development of spoken language as a form of communication and it has been used for therapeutic purposes in many ways throughout history. In patients with AD, musical memory has been noticed to be well-preserved and constituting a relatively independent part of memory. Music-based neurological rehabilitation provides a mode of treatment, which is free of side effects and can be personalized for patients with dementia.
Aims of this study are to examine how AD affects the structure of various brain areas associated with music processing and to statistically correlate musical cognition with memory performance in patients with AD. Focus is on brain areas associated with musical pleasure like the striatum, superior temporal gyrus, inferior frontal gyrus and areas associated with long-term musical memory like the anterior cingulate gyrus and presupplementary motor area. Hippocampal atrophy serves as a reference of the stage of AD. Our working hypothesis is that musicality correlates with preserved cognitive skills and memory.
Voluntary participants who have been diagnosed with AD are recruited from Turku University Central Hospital. Their musicality is assessed with a short version of Montreal Battery of Evaluation of Amusia which contains listening tasks that test the patients' memory, rhythm recognition and pitch discrimination. In addition, patients are asked to fill an inquiry that maps their use of music and its significance in their daily lives. Voxel-Based Morphometry is applied on MRI images to evaluate atrophy in the hippocampus and entorhinal cortex, which correlate with clinical stages of AD, as well as on the brain areas relevant for processing of music.
연구 유형
등록 (예상)
연락처 및 위치
연구 연락처
- 이름: Seppo Soinila, MD PhD
- 전화번호: +358503463396
- 이메일: seppo.soinila@tyks.fi
연구 연락처 백업
- 이름: Pavel Zaitsev, B.Sc.
- 이메일: pavel.p.zaitsev@utu.fi
참여기준
자격 기준
공부할 수 있는 나이
- 어린이
- 성인
- 고령자
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
샘플링 방법
연구 인구
설명
Inclusion Criteria:
Diagnosed Alzheimer´s disease
Exclusion Criteria:
Other neurological comorbidity, substance abuse
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 관찰 모델: 보병대
- 시간 관점: 회고전
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
---|---|---|
Montreal Battery of Evaluation of Amusia
기간: 60 minutes
|
Number of correct answers in three task collections (total 79 tasks)
|
60 minutes
|
Brain atrophy in MRI scans
기간: 120 minutes
|
Loss of volume in brain regions relevant for music processing and in the hippocampi estimated by voxel-based morphometry
|
120 minutes
|
CERAD (Consortium for Establishing Registry of Alzheimer´s Disease)
기간: 30 minutes
|
Level of cognitive impairment
|
30 minutes
|
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
---|---|---|
Use of music in patient´s daily life
기간: 30 minutes
|
Validated self-report questionnaire MusEQ in Finnish, Likert scale 1-5 (Vanstone AD et al, Aging Ment Health 2016)
|
30 minutes
|
공동 작업자 및 조사자
수사관
- 수석 연구원: Seppo Soinila, MD PhD, Turku University Hospital
연구 기록 날짜
연구 주요 날짜
연구 시작 (예상)
기본 완료 (예상)
연구 완료 (예상)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .