Principal Scientist 3

Charles River Laboratories International Inc (CRL)

Worcester, MA, US, 01608

Principal Scientist 3 Req ID #:  112063 Location: 

Worcester, MA, US, 01608 For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about. Job Summary  

We are seeking a Principal Scientist 3 for our Discovery site located Worcester, MA


We are seeking a highly-motivated individual with extensive hands-on experience in developing large molecule bioanalytical assays by LC-MS/MS to join our discovery bioanalytical team.  The scientist will be responsible for method development and execution of quantitative assays, critical review of data, mentoring junior staff, and maintaining analytical equipment.  Individuals in this role will also serve as primary point of communication with the clients.  The scientist is expected to work independently to deliver high-quality non-GLP data in a fast-paced environment.


The successful candidate in this position will have:

  A solid understanding of analytical approaches for the quantitation of siRNA, ASOs, proteins, antibodies and other complex modalities.    Experience in extraction and analysis of biological samples, data generation, review of results and scientific presentation Excellent scientific communication and interpersonal skills Demonstrated ability to work collaboratively in a team environment with colleagues at various levels Attention to detail and the ability to critically analyze and verify data prior to data release Experience in large molecule LC-MS bioanalysis with an emphasis on siRNA, ASOs, proteins, antibodies and complex modalities. Exceptional method development and assay troubleshooting skills Technical proficiency in operation of analytical instrumentation including chromatography and mass spectrometry systems (HPLC: Agilent, Waters Acquity, Thermo Vanquish; Mass Spectrometer: Sciex 5500 & 6500, Thermo QE HRMS)  Previous experience leading a team is preferred as this position will include responsibility for overseeing scientific growth and development of junior staff


The following are minimum qualifications related to the Principal Scientist 3 position:


Education: Bachelor's degree (B.S./B.A.) or equivalent in a scientific related discipline. Related Master's degree (M.S./M.A.) or Ph.D. preferred.

Experience:  Minimum of 9 years related experience in the contract research, academic, or pharmaceutical industry.  

An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.

Certification/Licensure: Certification as appropriate for specialty preferred.

Other:  Full understanding of regulatory requirements of study types assigned, as well as Testing Facility SOPs, as appropriate. Knowledge of applicable international guidelines for all types of studies. Demonstrate leadership skills as they pertain to intra- and interdepartmental initiatives, Sponsor interactions, and business development. Effective written and verbal communication skills. Ability to handle multiple projects, prioritize work and meet deadlines. Proficiency in the use of standard software including Microsoft® Excel, Word, PowerPoint, etc. and analytical instrumentation software. 



About Discovery

Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.


About Charles River

Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.


Equal Employment Opportunity


Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet.


If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to  [email protected] . This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications .


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Nearest Major Market: Worcester

Job Segment: Chemistry, Scientific, Biotech, Scientist, Pharmaceutical, Science, Engineering

2021-06-10 00:00:00

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