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Hoarding Older Adults

2018년 6월 26일 업데이트: VA Office of Research and Development

Treatment of Late Life Compulsive Hoarding

The purpose of this investigation is to examine treatment outcome of a new intervention for hoarding in older adults compared to standard case management for hoarding. The new intervention combines exposure therapy and cognitive remediation.

연구 개요

상태

완전한

정황

개입 / 치료

상세 설명

Research has shown that hoarding disorder (HD) is debilitating chronic and progressive condition that has significant public health implications. Older adults represent the largest group of HD suffers due to increasing severity with age. Often, Veterans with HD are seen in the VA system and the status of their hoarding is never assessed. Providers are treating patients for other health and social service issues yet missing an important source of disability and distress. This insidious, often undetected condition leads to greater medical and social disability and is costly to the VA system as patients continue to decompensate. When HD is even detected, patients in the VA receive indefinite case management and inadequate treatment. The cases the investigators know about have caused significant financial burden to the investigators' system. Most importantly, HD causes significant impairment and poor quality of life for the Veterans, particularly older Veterans. Unfortunately, the investigators know nothing about how to treat late life HD. Nor do the investigators know how neurocognitive features impact treatment response, which the investigators strongly suspect influence treatment outcome. HD is a potentially treatable source of disability in the VA system - one that the VA must research and treat. This study represents the first randomized controlled trial of a novel intervention for the treatment of HD in older Veterans. The main objective of this proposal is to further refine and test a new treatment for hoarding in older Veterans (age 60-85) which will be accomplished through a series of treatment development phases (case series, open labeled trial) and a randomized controlled trial. The new treatment (Cognitive Remediation and Exposure Therapy for hoarding; CogRET) is hypothesis driven and based on late life anxiety literature, consultation with mentors, results of the pilot study using a standard cognitive-behavioral intervention, and several case series that will be completed prior to the start of the Career Development Award (CDA). The first draft of CogRET is complete and is currently being used with several case studies. The research and training plan is divided into 5 phases; 1) training and preparation 2) training, further case studies using CogRET, further modification of CogRET 3)training, open label trial of CogRET, further modification of CogRET 4) randomized controlled trial and 5) presenting, publishing, dissemination of results and submission of a VA Merit grant. Primary hypotheses include 1) when randomized to CogRET, older Veterans with HD will show significant decreases in acquisition, difficulty discarding, and excessive clutter compared to those randomized to case management and 2) executive functioning (EF) is a significant moderator of treatment response. Other mediators and moderates of treatment response (psychiatric, medical, demographic, etc.) will be explored.

연구 유형

중재적

등록 (실제)

58

단계

  • 해당 없음

연락처 및 위치

이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.

연구 장소

    • California
      • San Diego, California, 미국, 92161
        • VA San Diego Healthcare System, San Diego, CA

참여기준

연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.

자격 기준

공부할 수 있는 나이

60년 (성인, 고령자)

건강한 자원 봉사자를 받아들입니다

아니

연구 대상 성별

모두

설명

Inclusion Criteria:

Participants must be between the ages of 60 - 85 years old and meet clinical criteria for Compulsive Hoarding (CH) developed by the Steketee and Frost (2000) research group. These criteria include:

  • significant amount of clutter in active living spaces
  • the urge to collect, buy, or acquire things
  • an extreme reluctance to part with items
  • clutter accumulation that causes distress or interferes with functioning
  • symptom duration of at least 6 months
  • the reluctance to part with items is not accounted for by other psychiatric conditions.

To be enrolled, patients must have:

  • a score of 20 or greater on the University of California, Los Angeles Hoarding Severity Scale (UHSS)
  • 40 or greater on the Savings Inventory-Revised (SI-R)
  • severity rating of 4 or higher on the Anxiety Disorders Interview Schedule (ADIS-IV) rating scales for clutter and difficulty discarding
  • and diagnosis confirmed at a consensus conference including at least two licensed professionals with expertise in CH (myself and at least one mentor).

Exclusion Criteria:

  • Individuals with moderate to severe cognitive deficits (scores below 23 on the MMSE) will be excluded.
  • Prospective participants must not have active substance abuse problems.
  • Participants will also be excluded if they are currently in other forms of psychotherapy.
  • Participants must have no change in any psychotropic medications for at least three months prior to the initial assessment.
  • Patients with current psychosis or mania will be excluded.
  • Mood and anxiety disorders are permitted as long as compulsive hoarding is the primary diagnosis.
  • Participants will are not eligible if they have active suicidal ideation, those participants will be given immediate medical or mental health attention.

공부 계획

이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.

연구는 어떻게 설계됩니까?

디자인 세부사항

  • 주 목적: 치료
  • 할당: 무작위
  • 중재 모델: 병렬 할당
  • 마스킹: 하나의

무기와 개입

참가자 그룹 / 팔
개입 / 치료
실험적: Arm 1: Cognitive Rehabilitation
Cognitive rehabilitation and exposure therapy for hoarding
The intervention includes cognitive remediation for deficits in executive functioning and exposure therapy for discarding/acquiring.
활성 비교기: Arm 2: Case Management
Case management
Case management

연구는 무엇을 측정합니까?

주요 결과 측정

결과 측정
측정값 설명
기간
Hoarding Symptom Severity as Measured by the Saving Inventory-Revised (SI-R) at 6 Months
기간: 6 months
Hoarding symptom severity (primary outcome) will be measured using the Savings Inventory-Revised (SI-R), a 23-item self-report measure used to assess common hoarding symptoms. Subtests include excessive clutter, compulsive acquisition, and difficulty discarding. The SI-R has demonstrated good internal consistency, divergent validity, concurrent validity, divergent validity, test-retest reliability in clinical samples with hoarding. The total score will be used for analyses. The range of the total score is 0-92, with higher scores indicating worse hoarding severity.
6 months

2차 결과 측정

결과 측정
측정값 설명
기간
The Activities of Daily Living in Hoarding (ADL-H)
기간: 6 months
The Activities of Daily Living in Hoarding (ADL-H) was used to assess functional impairment. Higher scores represent increased impairment. Mean score is 1-75, with higher scores indicating worse impairment due to hoarding.
6 months
Executive Functioning as Measured by the Delis Kaplan Executive Functioning System (D-KEFS) at 6 Months
기간: 6 months
The D-KEFS Trail Making Test Condition 4: Number-Letter Switching Scaled Score was used to assess executive functioning. Scaled scores range from 1-19. Higher scores represent less impairment.
6 months

공동 작업자 및 조사자

여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.

스폰서

수사관

  • 수석 연구원: Catherine R Ayers, PhD, VA San Diego Healthcare System, San Diego, CA

간행물 및 유용한 링크

연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.

연구 기록 날짜

이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.

연구 주요 날짜

연구 시작

2010년 11월 1일

기본 완료 (실제)

2015년 4월 1일

연구 완료 (실제)

2015년 4월 1일

연구 등록 날짜

최초 제출

2010년 10월 20일

QC 기준을 충족하는 최초 제출

2010년 10월 20일

처음 게시됨 (추정)

2010년 10월 22일

연구 기록 업데이트

마지막 업데이트 게시됨 (실제)

2018년 7월 24일

QC 기준을 충족하는 마지막 업데이트 제출

2018년 6월 26일

마지막으로 확인됨

2018년 6월 1일

추가 정보

이 연구와 관련된 용어

기타 연구 ID 번호

  • CSRD-068-10S

이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .