Open-Label Clinical Trial Evaluating the Impact of a Multi-Strain Commensal Probiotic Dietary Supplement on Gastrointestinal Microbiota Composition, Functional Gastrointestinal Markers, and Gastrointestinal Symptoms

Inclusion Criteria:

1. Adult females or males age ≥ 18 years
2. At least moderate gastrointestinal distress, defined as a score of ≥ 4 on any domain of the Gastrointestinal Symptoms Rating Scale (GSRS) at screening
3. Ability to read and speak English
4. Ability and willingness to collect an at-home stool sample for GI-MAP testing

Exclusion Criteria:

1. Current or recent (within the prior 90 days) use of a probiotic dietary supplement
2. Current or recent (within the prior 90 days) use of systemic antibiotics, antifungals, or antiparasitic medications
3. Known allergies to any ingredients in the product
4. Currently pregnant or lactating women or women planning to become pregnant in the next 8 weeks
5. Current diagnosis of inflammatory bowel disease (Crohn's disease or ulcerative colitis), celiac disease, active gastrointestinal malignancy, or other chronic health condition (e.g., cancer, heart failure, history of pancreatitis, type I or II diabetics on insulin) deemed clinically contraindicated for the study protocol
6. Severely immunocompromised status (e.g., active chemotherapy, post-transplant immunosuppression, advanced HIV)
7. Participants unable to provide consent