Cardiovascular Autonomic Function After Resistance Training
Effects of 8-Week Resistance Training on Cardiovascular Autonomic Function in Spinal Cord Injury
The purpose of this clinical trial is to evaluate whether an 8-week upper-limb resistance training program improves cardiovascular autonomic function in adults with chronic spinal cord injury (SCI). The primary objectives are to determine whether upper-limb resistance training improves heart rate variability (HRV) and baroreflex sensitivity (BRS), and whether it improves blood pressure responses during postural change, upper-limb strength, symptoms related to orthostatic hypotension, and quality of life.
Participants will be randomly assigned to either the resistance training group or the control group. All participants will complete assessments before and after the 8-week study period, including measurements of HRV, BRS, blood pressure responses during a tilt-table test, hand grip strength, and questionnaires assessing orthostatic hypotension symptoms and quality of life. Participants assigned to the resistance training group will participate in supervised upper-limb resistance training three times per week for 8 weeks.
연구 개요
상태
상태
정황
정황
개입 / 치료
개입 / 치료
상세 설명
SCI can impair cardiovascular autonomic function by disrupting the neural pathways that regulate heart rate and blood pressure. As a result, many individuals with SCI experience cardiovascular autonomic dysfunction, including orthostatic hypotension, which may increase cardiovascular health risks.
Although exercise is recommended for people with SCI, previous studies have mainly focused on aerobic exercise and have demonstrated inconsistent effects on cardiovascular autonomic function. Upper-limb resistance training is widely used in rehabilitation to improve strength and functional independence, but its effects on autonomic function have not been well established.
This randomized controlled trial will evaluate whether an 8-week upper-limb resistance training program improves cardiovascular autonomic function in adults with chronic SCI. The study will assess changes in HRV and BRS, while also exploring changes in orthostatic blood pressure responses, upper-limb strength, orthostatic hypotension symptoms, and quality of life. The findings may provide evidence supporting upper-limb resistance training as a rehabilitation strategy to improve cardiovascular autonomic function in individuals with chronic SCI.
연구 유형
연구 유형
등록 (추정된)
등록
단계
단계
- 해당 없음
연락처 및 위치
연구 연락처
연구 연락처
- 이름: Dogyu Lee, M.S.
- 전화번호: 055-360-1730
- 이메일: 2doq2doq@gmail.com
연구 연락처 백업
- 이름: Yuna Kim, B.S.
- 전화번호: 055-360-1730
- 이메일: kyoona1289@gmail.com
연구 장소
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Gyeongsangnam-do
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Yangsan, Gyeongsangnam-do, 대한민국, 50612
- Pusan National University Yangsan Hospital
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연락하다:
- Dogyu Lee, M.S.
- 전화번호: 055-360-1730
- 이메일: 2doq2doq@gmail.com
-
연락하다:
- Yuna Kim, B.S.
- 전화번호: 055-360-1730
- 이메일: kyoona1289@gmail.com
-
수석 연구원:
- Sungchul Huh, MD, PhD
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참여기준
자격 기준
자격 기준
공부할 수 있는 나이
- 성인
- 고령자
건강한 자원 봉사자를 받아들입니다
설명
Inclusion Criteria:
- Provided written informed consent and agreed to participate in the study.
- Adults aged 19 to 85 years.
- Chronic spinal cord injury (SCI) of traumatic or non-traumatic etiology, at least 6 months after injury.
- Cervical or thoracic spinal cord injury.
- Classified as American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade A, B, C, or D.
- Sufficient upper-limb range of motion to perform resistance training.
- Elbow extensor muscle strength of Manual Muscle Test (MMT) grade 3 or higher.
Exclusion Criteria:
- Presence of any serious medical condition that would preclude participation in the study.
- Inability to understand or perform the exercise program.
- Uncontrolled diabetes mellitus or progressive neurological disease.
- Uncontrolled hypertension (systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg).
- History of cardiovascular disease within the past 6 months.
- Current use of medications that may affect heart rate variability (HRV) or baroreflex sensitivity (BRS).
- Severe orthostatic hypotension (OH) or autonomic dysreflexia (AD).
- Considered unsuitable for participation in the study by a board-certified specialist in Physical and Rehabilitation Medicine.
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 없음(오픈 라벨)
팔의 수
무기와 개입
참가자 그룹 / 팔참가자 그룹 / 팔 |
개입 / 치료개입 / 치료 |
|---|---|
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실험적: Exercise group
Participants will receive a supervised upper-limb resistance training program three times per week for 8 weeks.
The program consists of progressive resistance exercises for the upper extremities.
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Participants will perform a supervised upper-limb resistance training program three times per week for 8 weeks.
Each session will last approximately 30 minutes and consist of progressive resistance exercises for the upper extremities.
Exercise intensity will be progressively adjusted according to each participant's tolerance.
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간섭 없음: Control group
Participants will continue their usual daily activities without participating in the resistance training program during the 8-week study period.
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연구는 무엇을 측정합니까?
주요 결과 측정
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Heart Rate Variability
기간: Baseline and Week 8
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Heart rate variability will be assessed to evaluate changes in cardiovascular autonomic function following the 8-week intervention.
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Baseline and Week 8
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Baroreflex Sensitivity
기간: Baseline and Week 8
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Baroreflex sensitivity will be assessed to evaluate changes in cardiovascular autonomic function following the 8-week intervention.
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Baseline and Week 8
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2차 결과 측정
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Orthostatic Hypotension
기간: Baseline and Week 8
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Orthostatic hypotension will be assessed by changes in systolic and diastolic blood pressure (ΔSBP and ΔDBP) during postural change using a tilt table.
Orthostatic hypotension will be defined as a decrease in systolic blood pressure of ≥20 mmHg or diastolic blood pressure of ≥10 mmHg.
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Baseline and Week 8
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Grip Strength
기간: Baseline and Week 8
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Grip strength will be measured using a hand dynamometer to evaluate changes in upper-limb muscle strength following the intervention.
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Baseline and Week 8
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Orthostatic Hypotension Symptoms (ADFSCI)
기간: Baseline and Week 8
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Orthostatic hypotension-related symptoms will be assessed using the orthostatic hypotension items of the Autonomic Dysfunction Following Spinal Cord Injury (ADFSCI) questionnaire.
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Baseline and Week 8
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Quality of Life (WHOQOL-BREF)
기간: Baseline and Week 8
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Quality of life will be assessed using the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire.
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Baseline and Week 8
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공동 작업자 및 조사자
수사관
수사관
- 수석 연구원: Sungchul Huh, MD, PhD, Pusan National University Yangsan Hospital
연구 기록 날짜
연구 주요 날짜
연구 시작 (추정된)
연구 시작
기본 완료 (추정된)
기본 완료
연구 완료 (추정된)
연구 완료
연구 등록 날짜
최초 제출
최초 제출
QC 기준을 충족하는 최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
처음 게시됨
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
마지막 업데이트 게시됨
QC 기준을 충족하는 마지막 업데이트 제출
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
추가 관련 MeSH 약관
기타 연구 ID 번호
기타 연구 ID 번호
- 11-2026-006
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
미국 FDA 규제 기기 제품 연구
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