Yoga, Immune Function, and Health
2016년 6월 6일 업데이트: Janice Kiecolt-Glaser, Ohio State University
Psychoneuroimmunology and Mind-Body Interventions
This study is designed to examine the impact of hatha yoga on immune and hormonal functioning in healthy individuals.
연구 개요
상세 설명
This study is designed to examine the effects of hatha yoga on autonomic, immune, and endocrine function.
The data from both inexperienced and experienced groups will help us better understand how longer-term practice of yoga may be beneficial.
The study consists of one 3-hour screening session and three 6-hour activity sessions with 30 minute follow-up appointments the following morning scheduled 2 - 4 weeks apart.
Each participant will complete the 3 activity sessions, which will consist of either yoga, mild movement, or a neutral activity (watching a videotape), in randomly assigned order.
Thus, both novices and experts will participate in 3 activity sessions each (yoga, movement control, video control).
The order in which each participant goes through the activity sessions is counterbalanced.
Data for each activity session will be aggregated by group (i.e.
novice or expert).
We will measure responses to tape stripping to assess skin barrier repair, and evaluate responses to computer tasks, self-report measures, and a battery of unobtrusive behavioral measures.
We will also collect blood and saliva samples to measure immune and endocrine outcomes.
연구 유형
중재적
등록 (실제)
52
단계
- 해당 없음
연락처 및 위치
이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.
연구 장소
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Ohio
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Columbus, Ohio, 미국, 43210
- Ohio State University Clinical Research Center
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참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
공부할 수 있는 나이
30년 (성인, 고령자)
건강한 자원 봉사자를 받아들입니다
예
연구 대상 성별
여성
설명
Inclusion Criteria:
- healthy female adults
- relatively inexperienced with yoga (beginner)
- experienced with yoga (advanced practitioner)
Exclusion Criteria:
- Treatment with medication that has immunological or endocrinological consequences
- Chronic health problems that affect immune or endocrine systems
- Anemia
- Use of psychoactive drugs or mood-altering medication
- Smoking
- Needle or blood phobias
- Tape or bandage allergies
- Pregnancy or nursing within the previous 3 months
- Heart problems
- History of hip or knee replacement surgery, displaced vertebrae, and any other physical limitations that would prevent full participation in the program
- use of statins, beta blockers
- excessive alcohol use
- convulsive disorders
- Body Mass Index (BMI) ≥ 30.
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 크로스오버 할당
- 마스킹: 하나의
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
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실험적: Hatha yoga classes
Groups consisted of novices or experts.
Groups were counterbalanced to ensure that equal number of novices and experts participated in each possible session combination, in a randomly assigned order.
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Iyengar yoga, the form of hatha yoga used in this study, emphasizes the use of props to help students achieve precise postures safely and comfortably according to their particular body types and needs.
The yoga activity sessions were directed by four experienced yoga teachers following a script.
The poses used were (in order) Supta Baddha Konasana (Reclining Bound Angle Pose), Adho Mukha Svanasana (Downward Facing Dog), Supported Uttanasana (Intense Forward Stretch), Parsvotanasana (Intense Side Stretch Pose), Prasarita Padottanansana (Wide-Legged Forward Bend), Janu Sirsasana (Head to Knee Pose), Bharadvajasana (Simple Seated Twist Pose), Viparita Karani (Restful Inversion), Supported Setu Bandha Sarvanagasana (Bridge Pose), and Savasana (Corpse Pose).
Blood draws occurred during the last two minutes of Supta Baddha Konasana (pose held 10 minutes), Viparita Karani (10 minutes), and Savasana (15 minutes).
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가짜 비교기: Movement Control
Non-Hatha yoga gentle movement.
Groups consisted of novices or experts.
Groups were counterbalanced to ensure that equal number of novices and experts participated in each possible session combination, in a randomly assigned order.
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Walking on a treadmill at .5 miles per hour was used to control for general physical movement/cardiovascular expenditure because it best approximated the heart rates during the restorative yoga session.
To match the lower heart rate, women also rested supine on a bed for several minutes after walking, before and after getting their blood drawn.
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간섭 없음: Passive Video Control
Another control condition, a neutral video that did not include any music, allowed us to contrast the effects of yoga with no activity.The session included a sequence on how to design physics experiments for a high school classroom, as well as segments from two lectures on polymers and quantum mechanics.
Groups were counterbalanced to ensure that equal number of novices and experts participated in each possible session combination, in a randomly assigned order.
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Number of Participants With Detectable C-Reactive Protein (CRP)
기간: 8:30 a.m. at each of the three visits, scheduled at least 2 weeks apart
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High sensitivity C-reactive protein (hsCRP) assessed once at baseline, at each of the three visits.
The hsCRP assay was performed using chemiluminescence methodology with the Immulite 1000 (Siemens Medical Solutions, Los Angeles, Ca.)
The lowest level of detection is .3
mg/dL.
43% of the values were below this lower bound, thus hsCRP was dichotomized as undetectable/detectable.
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8:30 a.m. at each of the three visits, scheduled at least 2 weeks apart
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Cortisol
기간: Day 1 8:30, 10:05, 10:58, 11:35, 12:05, 13:10. Day 2 7:30
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All cortisol and catecholamine samples for a subject were frozen after collection and analyzed within the same assay run after the participant had completed the study.
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Day 1 8:30, 10:05, 10:58, 11:35, 12:05, 13:10. Day 2 7:30
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Skin Barrier Repair: Trans-epidermal Water Loss (TEWL)
기간: 11:50, 12:50 at each of the three visits, scheduled at least 2 weeks apart
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Cellophane tape stripping, a common dermatological paradigm for studying restoration of the skin barrier, was used to examine whether the time necessary for recovery from minor physical insults varied by condition or yoga expertise.
Measurement of the rate of transepidermal water loss (TEWL) through human skin provides a noninvasive method to monitor changes in the skin's barrier function.
TEWL was measured twice during the session using a computerized evaporimetry instrument, the DermaLab® (CyberDERM, Media, PA), and barrier recovery was calculated.
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11:50, 12:50 at each of the three visits, scheduled at least 2 weeks apart
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Immune Function: Soluble Interleukin-6 Receptor (sIL-6r)
기간: Day 1 8:30, 11:35, 13:10. Day 2 7:30
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Serum levels of the sIL-6r were assayed using Quantikine High Sensitivity Immunoassay kits (R&D), per kit instructions.
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Day 1 8:30, 11:35, 13:10. Day 2 7:30
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Immune Function: Tumor Necrosis Factor-alpha (TNF-α)
기간: Day 1 8:30, 11:35, 13:10. Day 2 7:30
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Serum levels of TNF-α were assayed using Quantikine High Sensitivity Immunoassay kits (R&D), per kit instructions.
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Day 1 8:30, 11:35, 13:10. Day 2 7:30
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Immune Function: Lipopolysaccharide (LPS) -Stimulated Production of Interleukin-6 (IL-6)
기간: Day 1 8:30, 10:05, 11:35, 13:10. Day 2 7:30
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Supernatants from PBLs stimulated with 5μg/ml lipopolysaccharide (LPS) for 72 h were assayed for IL-6 and TNF-α using ELISA kits (B-D Pharmingen).
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Day 1 8:30, 10:05, 11:35, 13:10. Day 2 7:30
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Immune Function: LPS-stimulated Production of TNF-α
기간: Day 1 8:30, 10:05, 11:35, 13:10. Day 2 7:30
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Supernatants from PBLs stimulated with 5μg/ml lipopolysaccharide (LPS) for 72 h were assayed for IL-6 and TNF-α using ELISA kits (B-D Pharmingen).
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Day 1 8:30, 10:05, 11:35, 13:10. Day 2 7:30
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Immune Function: Interleukin-6 (IL-6)
기간: Day 1 8:30, 11:35, 13:10. Day 2 7:30
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Serum levels of TNF-α, IL-6, and the sIL-6r were assayed using Quantikine High Sensitivity Immunoassay kits (R&D), per kit instructions
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Day 1 8:30, 11:35, 13:10. Day 2 7:30
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Catecholamine Production: Epinephrine
기간: 8:30, 10:05, 10:28, 10:58, 11:35, 12:05 at each of the three visits, scheduled at least 2 weeks apart
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All cortisol and catecholamine samples for a subject were frozen after collection and analyzed within the same assay run after the participant had completed the study.
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8:30, 10:05, 10:28, 10:58, 11:35, 12:05 at each of the three visits, scheduled at least 2 weeks apart
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Catecholamine Production: Norepinephrine
기간: 8:30, 10:05, 10:28, 10:58, 11:35, 12:05
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All cortisol and catecholamine samples for a subject were frozen after collection and analyzed within the same assay run after the participant had completed the study.
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8:30, 10:05, 10:28, 10:58, 11:35, 12:05
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Heart Rate
기간: Day 1: 8:30, 9:15, 9:45, 10:00, 10:45, 11:35, 12:05, 12:15
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Day 1: 8:30, 9:15, 9:45, 10:00, 10:45, 11:35, 12:05, 12:15
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Blood Pressure
기간: 7:55 at each of the three visits, scheduled at least 2 weeks apart
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7:55 at each of the three visits, scheduled at least 2 weeks apart
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Mood: Positive and Negative Affect Schedule (PANAS)Positive
기간: 7:35, 11:45, 12:30 at each of the three visits, scheduled at least 2 weeks apart
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The Positive and Negative Affect Schedule (PANAS) includes two 10-item mood scales.
Each item is rated on a 5-point scale ranging from 1 = very slightly or not at all to 5 = extremely, to indicate the extent to which the respondent has felt this way in the indicated time frame.
Several additional words were added to better capture low positive affect: happy, satisfied, disappointed, discouraged, low, sad.
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7:35, 11:45, 12:30 at each of the three visits, scheduled at least 2 weeks apart
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Mood: Positive and Negative Affect Schedule (PANAS)Negative
기간: 7:35, 11:45, 12:30 at each of the three visits, scheduled at least 2 weeks apart
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The Positive and Negative Affect Schedule (PANAS) includes two 10-item mood scales.
Each item is rated on a 5-point scale ranging from 1 = very slightly or not at all to 5 = extremely, to indicate the extent to which the respondent has felt this way in the indicated time frame.
Several additional words were added to better capture low positive affect: happy, satisfied, disappointed, discouraged, low, sad.
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7:35, 11:45, 12:30 at each of the three visits, scheduled at least 2 weeks apart
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공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
수사관
- 수석 연구원: Janice K. Kiecolt-Glaser, PhD, Ohio State University
간행물 및 유용한 링크
연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.
연구 기록 날짜
이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.
연구 주요 날짜
연구 시작
2005년 9월 1일
기본 완료 (실제)
2008년 9월 1일
연구 완료 (실제)
2008년 9월 1일
연구 등록 날짜
최초 제출
2006년 8월 31일
QC 기준을 충족하는 최초 제출
2006년 8월 31일
처음 게시됨 (추정)
2006년 9월 4일
연구 기록 업데이트
마지막 업데이트 게시됨 (추정)
2016년 7월 6일
QC 기준을 충족하는 마지막 업데이트 제출
2016년 6월 6일
마지막으로 확인됨
2016년 6월 1일
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
Hatha Yoga Classes에 대한 임상 시험
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