약물 과용 두통에 해독이 필요합니까? (DEFINE3)

Patients with medication-overuse headache:

Inclusion Criteria:

• Confirmed MOH diagnosis according to the ICHD-III beta (1).
• Eligible for outpatient treatment based on type of medication overuse (without massive pure opioids and barbiturates overuse), and personal resources and motivation.
• Capable of completing headache diary/calendar.
• Age ≥ 18 years old and capable of providing informed consent.
• Medication-overuse headache based on initial tension-type headache (TTH) or migraine.
• Signed informed consent.

Exclusion Criteria:

• Severe physical illness or psychiatric disorders.
• Addiction to alcohol or other drugs.
• Current treatment with headache prophylaxis. Patients can be included minimum 5 weeks after stop of prophylaxis.
• Pregnancy, breastfeeding or planned pregnancy within the next 12 months.
• Inability to provide reliable information about medical history.

Criteria for Control group 1 - Episodic migraineurs:

• Episodic migraine, with/without concomitant tension-type headache, according to the ICHD-III beta.
• Headache days / month ≤ 6 at time of inclusion.
• Days with analgesics / month ≤ 6 at time of inclusion.
• Prophylactics are allowed.
• Age ≥ 18 years old.
• Ability to fill out headache calendar.
• No previous medication overuse.
• No significant co-morbid pain, physical or psychiatric disorders.
• No addiction to alcohol or drug-abuse.
• No pregnancy, breastfeeding or planned pregnancy within the next 12 months.

Criteria for Control group 2 - Healthy volunteers:

•≥ 2 days with headache in the past month at time of inclusion.

• Days with analgesics / month ≤ 6 at time of inclusion.
• Age ≥ 18 years old.
• No significant co-morbid pain, physical or psychiatric disorders.
• No addiction to alcohol or drug-abuse.
• No pregnancy, breastfeeding or planned pregnancy within the next 12 months.